Results 211 to 220 of about 56,978 (263)

Functional characterization of DPP4 and FcRn as receptor and coreceptor for classical human astroviruses in Caco-2 cells. [PDF]

PLoS Pathog
Aguilera-Flores C, Valencia-Morales MDP, López T, Moreno-Contreras J, Lentz A, Espinoza MA, DuBois RM, López S, Arias CF.   +8 more
europepmc   +1 more source

An Exploratory Study of the Nutritional Composition and Caco-2 Safety Assessment of Elche Date Flour and Its Green Hydroethanolic Extracts. [PDF]

Foods
Dawidowicz K, Martinez-Terol S, Sayas-Barberá E, Pérez-Álvarez JÁ, Marti-Quijal FJ, Roig P, Castagnini JM.   +6 more
europepmc   +1 more source

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Usefulness of Caco-2/HT29-MTX and Caco-2/HT29-MTX/Raji B Coculture Models To Predict Intestinal and Colonic Permeability Compared to Caco-2 Monoculture

Molecular Pharmaceutics, 2017
The Caco-2 cellular monolayer is a widely accepted in vitro model to predict human permeability but suffering from several and critical limitations. Therefore, some alternative cell cultures to mimic the human intestinal epithelium, as closely as possible, have been developed to achieve more physiological conditions, as the Caco-2/HT29-MTX coculture ...
Marival Bermejo, Bruno Sarmento, Francisca Araujo   +2 more
exaly   +4 more sources

Manganese transport by caco-2 cells

Biological Trace Element Research, 1999
The uptake and transport kinetics of manganese (Mn) were investigated in the human intestinal Caco-2 cell line both from the absorption side (apical to basolateral) and from the exsorption side (basolateral to apical). With regard to the former, transport versus time revealed (as uptake) a biphasic pattern with an initial transient phase followed by ...
G, Leblondel, P, Allain
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Good Caco-2 cell culture practices

Toxicology in Vitro, 2012
The human Caco-2 cells differentiate spontaneously in culture forming monolayers of mature intestinal enterocytes which have been used as a model of the intestinal barrier for in vitro toxicology studies. Reproducibility problems often reported in literature have been generally ascribed to different culture-related conditions, such as the type of ...
Natoli Manuela, Leoni Bruno D, D'Agnano Igea, Zucco Flavia, Armando Felsani   +4 more
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Caco‐2 Cells as a Model for Intestinal Absorption

Current Protocols in Toxicology, 2011
AbstractThe Caco‐2 cell system, a well characterized intestinal in vitro model, makes it possible to evaluate the ability of chemicals to cross the intestinal barrier, as well as to study their transport mechanisms. Permeability values estimated with this model correlate well with human in vivo absorption data for many drugs and chemicals.
Isabella De, Angelis, Laura, Turco
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Endogenous lipase activity in Caco-2 cells

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1998
Dietary triglycerides, the major precursors of long chain fatty acids (FA), require hydrolysis by pancreatic enzymes prior to their absorption by the small intestine. Although Caco-2 cells are frequently employed for the study of enterocyte lipid metabolism, the presence of an endogenous lipase activity has never been previously reported.
J H, Spalinger, E G, Seidman, D, Ménard, E, Levy   +3 more
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ERGOVALINE MOVEMENT ACROSS CACO-2 CELLS

In Vitro Cellular and Developmental Biology--Animal, 2005
Ergovaline's role in the direct causation of fescue toxicosis first requires establishment of its dietary absorption. Therefore, ergovaline movement across human intestinal cells was assessed using Caco-2 cells derived from human colon carcinoma. A pre-equilibrated mixture of ergovaline/ergovalinine (60:40 ratio of isomers) was added to the apical ...
Nancy W, Shappell, David J, Smith
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The Caco-2 cell monolayer: usefulness and limitations

Expert Opinion on Drug Metabolism & Toxicology, 2008
The Caco-2 monolayer has been used extensively for the high-throughput screening of drug permeability and identification of substrates, inhibitors, and inducers of intestinal transporters, especially P-glycoprotein (P-gp). Traditionally, the Caco-2 monolayer is viewed as a single barrier rather than a polarized cell monolayer consisting of metabolic ...
Huadong, Sun, Edwin Cy, Chow, Shanjun, Liu, Yimin, Du, K Sandy, Pang   +4 more
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The role of CDX2 in Caco-2 cell differentiation

European Journal of Pharmaceutics and Biopharmaceutics, 2013
CDX2 plays a key part in the differentiation of Caco-2 cells, a colon carcinoma derived cell line that undergoes spontaneous differentiation. The effect of CDX2 expression in Caco-2 cells over time in culture has not been studied yet on a genome-wide level.The impact of CDX2 expression on the genomic profile of Caco-2 cells was studied by transducing ...
Natoli Manuela, Christensen Jon, ElGebali Sara, Felsani Armando, Anderle Pascale   +4 more
openaire   +2 more sources