Results 221 to 230 of about 97,542,255 (296)

An explanatory in vitro study on the effect of copper gluconate on ferrous gluconate absorption in a Caco-2 cell model. [PDF]

BMC Res Notes
Belabed Y, Lopez B, Escola J, Gobert O, Talbot CP, Carrois F.   +5 more
europepmc   +1 more source

Backbone Steric Constraints Underlie High Passive Membrane Permeability of N‐Alkyl Peptides

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
Beyond amide hydrogen removal, steric constraints encoded in N/Cα‐dually substituted backbones are uncovered as a key determinant of passive membrane permeability in N‐alkyl peptides. These constraints restrict conformational freedom and sterically limit backbone hydration during membrane permeation.
Ayumi Inayoshi, Mariko Akiba, Marin Yokomine, Masatake Sugita, Koji Umezawa, Yuto Hirota, Yutaka Akiyama, Jumpei Morimoto, Shinsuke Sando   +8 more
wiley   +2 more sources

Tormentil Rhizome Ethanolic Extract and Its Gut Microbiota-Derived Metabolites: Modulation of Tight Junction Integrity and Anti-Inflammatory Potential in Caco-2 Cells. [PDF]

J Agric Food Chem
Kruk A, Grześkowiak Ł, Vlasova I, Kostenko Y, Zentek J, Granica S, Piwowarski JP.   +6 more
europepmc   +1 more source

Diethylene Glycol‐Linked Ring‐Fused Bis‐Azoles: Target‐Oriented Synthesis, In Silico Screening, and Antitumor Activity

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A series of diethylene glycol‐linked cyclic derivatives with diversity in the heterocyclic motif have been synthesized and screened for antitumor activity. Two bis‐thiazolo[3,2‐a]pyrimidinone derivatives displayed moderate cytotoxicity, high selectivity against hepatocellular carcinoma cells, promising VEGFR2, and remarkable FGFR2 inhibitory activities
Sami A. Al‐Hussain, Abdulrahman S. Alharbi, Zeinab A. Muhammad, Alyaa S. Abdel Halim, Magdi E. A. Zaki, Mark C. Bagley, Refaie M. Kassab   +6 more
wiley   +1 more source

CaliciBoost: Performance-driven evaluation of molecular representations for caco-2 permeability prediction. [PDF]

J Cheminform
Le HV, Ren W, Kim J, Yun Y, Park YB, Kim YJ, Han BK, Choi I, Park JI, Yun HY, Choi JM.   +10 more
europepmc   +1 more source

Hitting Coronaviruses Where It Hurts: Antiviral Strategies Targeting Viral Proteins

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Viral proteins represent key vulnerabilities in human coronaviruses (HCoVs). This review outlines inhibitors targeting spike (S), main protease (Mpro), papain‐like protease (PLpro), and RNA‐dependent RNA polymerase (RdRp), mapping chemically diverse strategies that disrupt entry and replication, and provides an integrated view of current candidates ...
Álvaro de la Cruz‐Potenciano, Miguel Maldonado, María‐José Camarasa, Sonia de Castro   +3 more
wiley   +1 more source

A Sea Buckthorn Pomace Polysaccharide Mitigates H₂O₂-Induced Impairment of Intestinal Barrier Integrity in Caco-2 Monolayers. [PDF]

Foods
Zhao J, Miao H, Wu F, Wei J.
europepmc   +1 more source

Valorization of <i>Schizophyllum commune</i> mycelia through green extraction and hydrolysate preparation: Proteomics-informed antioxidant potential and Caco-2 cell-based assessment. [PDF]

Food Chem X
Kongsinkaew C, Chrakankun S, Cutroneo S, Accardo F, Tedeschi T, Petchkongkaew A, Dall'Asta C, Call F, Crudo F, Grgic D, Marko D, Charoenrat T.   +11 more
europepmc   +1 more source

Effects of irisin on inflammatory and apoptotic markers in the Caco-2 colon cancer cell line. [PDF]

BMC Mol Cell Biol
Ozturk EZ, Bakan E, Baygutalp NK, Bayraktutan Z.   +3 more
europepmc   +1 more source

<i>Bacillus cereus</i> enterotoxins change epithelial barrier function and ion transport in a Caco-2/HT29-MTX co-culture model, provoking inflammation, apoptosis and membrane damage. [PDF]

Virulence
Albahri M, Seeger B, Beineke A, Esatbeyoglu T, Plötz M, Jessberger N.   +5 more
europepmc   +1 more source