Results 231 to 240 of about 56,978 (263)
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Transport of thalidomide by the human intestinal Caco-2 monolayers
European Journal of Drug Metabolism and Pharmacokinetics, 2005Studies in patients have indicated that the oral absorption of thalidomide is considerably variable at high doses (>200 mg/day). The aim of this study was to investigate the transport of racemic thalidomide using human colon cancer cell line (Caco-2) monolayers, which have been widely used to investigate drug permeability. A typical 21-day protocol was
Zhou, Shufeng +5 more
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Stereoselectivity of the reduced folate carrier in Caco‐2 cells
Chirality, 2005AbstractStereoselectivity of the human reduced folate carrier (RFC1) was examined in Caco‐2 cells using methotrexate (l‐amethopterin or l‐MTX) and its antipode (d‐amethopterin or d‐MTX) as model substrates. The initial uptake rate of folic acid (FA) was concentration dependent, with a Km value of approximately 0.6 μM. The Eadie–Hofstee plot of the RFC1‐
Tomoya, Narawa +6 more
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Transepithelial Taurine Transport in Caco-2 Cell Monolayers
Journal of Membrane Biology, 2005Here we characterized transepithelial taurine transport in monolayers of cultured human intestinal Caco-2 cells by analyzing kinetic apical and basolateral uptake and efflux parameters. Basolateral uptake was Na(+)- and Cl(-)- dependent and was inhibited by beta-amino acids.
S, Roig-Pérez, M, Moretó, R, Ferrer
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Campylobacter jejuni motility and invasion of Caco-2 cells
Infection and Immunity, 1995We investigated the influence of motility on Campylobacter jejuni binding and invasion of Caco-2 cells. C. jejuni was motile in soft agar at basic (pH 8.5) and neutral pH values representative of the intestinal environment. However, C. jejuni was immobilized at pH 5.0. The inability of C.
C M, Szymanski +3 more
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Toxic and biochemical effects of zinc in Caco-2 cells
Journal of Inorganic Biochemistry, 2003Zinc (in relatively high concentrations) can be toxic to intestinal cells. The aim of the present study was to quanitfy cellular injury in preconfluent, colonic cancerous cells and in postconfluent, differentiating human intestinal Caco-2 cells. Cellular damage was measured by using cell proliferation, lactate dehydrogenase (LDH)-release, and apoptosis
Zödl, Bettina +6 more
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Competition Effects on Carotenoid Absorption by Caco-2 Cells
2009International ...
Reboul, Emmanuelle, Borel, Patrick
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Putrescine transport in differentiated Caco-2 cells.
Gastroenterologie clinique et biologique, 1996To evaluate the putative importance of digestive luminal polyamines, we investigated the role of oxidation in putrescine uptake and transport in differentiated Caco-2 cells grown in monolayer.Our results confirm a putrescine uptake system located both at the apical and basolateral cell membrane. Putrescine is efficiently transported and excreted in the
Barlier, A.M. +2 more
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Cholesterol Trafficking in CaCo-2 Cells
1998In CaCo-2 cells, the transport of cholesterol from the plasma membrane to the endoplasmic reticulum occurs via transport vesicles, likely derived from specialized domains of the plasma membrane. Agents that inhibit p-glycoprotein activity interfere with the transport of plasma membrane cholesterol to the endoplasmic reticulum and the secretion of ...
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CHARACTERIZATION OF GUANYLIN SECRETION IN CACO‐2 CELLS
Journal of Pediatric Gastroenterology and Nutrition, 1999J A Rudolph, J A Hawkins, M B Cohen
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Endocytic and transcytic pathways in Caco-2 cells
Biochemical Society Transactions, 1992J P, Luzio, M R, Jackman, J A, Ellis
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