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Conjugates of desferrioxamine with 5-aminolevulinic or γ-aminobutyric acid: synthesis, theoretical studies, iron-chelating ability, and penetration in human Caco-2 cells. [PDF]
BiometalsLacerda E +3 more
europepmc +1 more source
Permeability of 16 Straight- and Branched-Chain Parabens Using the Caco-2 Assay. [PDF]
J Appl ToxicolHewitt NJ +3 more
europepmc +1 more source
Molecular descriptor driven QSPR modeling of Papp, TEER and Efflux Ratio from Caco-2 cells using machine learning for various phytochemicals. [PDF]
J Sci Food AgricKim JW +5 more
europepmc +1 more source
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Molecular Pharmaceutics, 2017
The Caco-2 cellular monolayer is a widely accepted in vitro model to predict human permeability but suffering from several and critical limitations. Therefore, some alternative cell cultures to mimic the human intestinal epithelium, as closely as possible, have been developed to achieve more physiological conditions, as the Caco-2/HT29-MTX coculture ...
Marival Bermejo +2 more
exaly +4 more sources
The Caco-2 cellular monolayer is a widely accepted in vitro model to predict human permeability but suffering from several and critical limitations. Therefore, some alternative cell cultures to mimic the human intestinal epithelium, as closely as possible, have been developed to achieve more physiological conditions, as the Caco-2/HT29-MTX coculture ...
Marival Bermejo +2 more
exaly +4 more sources
The Caco-2 Cell Monolayer: Usefulness and Limitations
Expert Opinion on Drug Metabolism and Toxicology, 2008The Caco-2 monolayer has been used extensively for the high-throughput screening of drug permeability and identification of substrates, inhibitors, and inducers of intestinal transporters, especially P-glycoprotein (P-gp). Traditionally, the Caco-2 monolayer is viewed as a single barrier rather than a polarized cell monolayer consisting of metabolic ...
K Sandy Pang, Huadong Sun
exaly +3 more sources
Manganese transport by caco-2 cells
Biological Trace Element Research, 1999The uptake and transport kinetics of manganese (Mn) were investigated in the human intestinal Caco-2 cell line both from the absorption side (apical to basolateral) and from the exsorption side (basolateral to apical). With regard to the former, transport versus time revealed (as uptake) a biphasic pattern with an initial transient phase followed by ...
G, Leblondel, P, Allain
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Good Caco-2 cell culture practices
Toxicology in Vitro, 2012The human Caco-2 cells differentiate spontaneously in culture forming monolayers of mature intestinal enterocytes which have been used as a model of the intestinal barrier for in vitro toxicology studies. Reproducibility problems often reported in literature have been generally ascribed to different culture-related conditions, such as the type of ...
Natoli Manuela +4 more
openaire +4 more sources
, 2015 The human epithelial cell line Caco-2 has been widely used as a model of the intestinal epithelial barrier. The Caco-2 cell line is originally derived from a colon carcinoma. However, one of its most advantageous properties is its ability to spontaneously differentiate into a monolayer of cells with many properties typical of absorptive enterocytes ...
exaly +2 more sources