Activation of the l-fucose utilization cluster in Campylobacter jejuni induces proteomic changes and enhances Caco-2 cell invasion and fibronectin binding. [PDF]
HeliyonMiddendorf PS +6 more
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Assessment of Digestion and Absorption Properties of 1,3-Dipalmitoyl-2-Oleoyl Glycerol-Rich Lipids Using an In Vitro Gastrointestinal Digestion and Caco-2 Cell-Mediated Coupled Model. [PDF]
MoleculesChang HJ, Lee AY, Lee JH.
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Optimization of Conditions of Zanthoxylum Alkylamides Liposomes by Response Surface Methodology and the Absorption Characteristics of Liposomes in the Caco-2 Cell Monolayer Model. [PDF]
ACS OmegaWang R, Rao C, Liu Q, Liu X.
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Good Caco-2 Cell Culture Practices
Toxicology in Vitro, 2012The human Caco-2 cells differentiate spontaneously in culture forming monolayers of mature intestinal enterocytes which have been used as a model of the intestinal barrier for in vitro toxicology studies. Reproducibility problems often reported in literature have been generally ascribed to different culture-related conditions, such as the type of ...
Armando Felsani, Igea D'Agnano
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Manganese transport by caco-2 cells
Biological Trace Element Research, 1999The uptake and transport kinetics of manganese (Mn) were investigated in the human intestinal Caco-2 cell line both from the absorption side (apical to basolateral) and from the exsorption side (basolateral to apical). With regard to the former, transport versus time revealed (as uptake) a biphasic pattern with an initial transient phase followed by ...
G, Leblondel, P, Allain
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Caco‐2 Cells as a Model for Intestinal Absorption
Current Protocols in Toxicology, 2011AbstractThe Caco‐2 cell system, a well characterized intestinal in vitro model, makes it possible to evaluate the ability of chemicals to cross the intestinal barrier, as well as to study their transport mechanisms. Permeability values estimated with this model correlate well with human in vivo absorption data for many drugs and chemicals.
Isabella De, Angelis, Laura, Turco
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Endogenous lipase activity in Caco-2 cells
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1998Dietary triglycerides, the major precursors of long chain fatty acids (FA), require hydrolysis by pancreatic enzymes prior to their absorption by the small intestine. Although Caco-2 cells are frequently employed for the study of enterocyte lipid metabolism, the presence of an endogenous lipase activity has never been previously reported.
J H, Spalinger +3 more
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The Caco-2 cell monolayer: usefulness and limitations
Expert Opinion on Drug Metabolism & Toxicology, 2008The Caco-2 monolayer has been used extensively for the high-throughput screening of drug permeability and identification of substrates, inhibitors, and inducers of intestinal transporters, especially P-glycoprotein (P-gp). Traditionally, the Caco-2 monolayer is viewed as a single barrier rather than a polarized cell monolayer consisting of metabolic ...
Huadong, Sun +4 more
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Oxidative stress of alternariol in Caco-2 cells
Toxicology Letters, 2014Alternariol (AOH) is a mycotoxin produced by fungus Alternaria. It is found in a wide variety of fruits and cereals products. AOH is able to damage human health. The aim of this study was to evaluate the cytotoxicity of AOH in human colon adenocarcinoma (Caco-2) cells.
Celia, Fernández-Blanco +2 more
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ERGOVALINE MOVEMENT ACROSS CACO-2 CELLS
In Vitro Cellular and Developmental Biology--Animal, 2005Ergovaline's role in the direct causation of fescue toxicosis first requires establishment of its dietary absorption. Therefore, ergovaline movement across human intestinal cells was assessed using Caco-2 cells derived from human colon carcinoma. A pre-equilibrated mixture of ergovaline/ergovalinine (60:40 ratio of isomers) was added to the apical ...
Nancy W, Shappell, David J, Smith
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