Results 131 to 140 of about 54,220 (246)

Salicifoliosides A and B: A Pair of Furan Glycoside Isomers From Chimonanthus salicifolius and Their Modulation of the Functions of Caco-2 Cells. [PDF]

Chem Biodivers
Yang HZ, Wu YW, Shangguan WJ, Min R, Zhang WT, Chen L, Yang K, Xu TH, Zhu YD, Fan XR.   +9 more
europepmc   +1 more source

Therapeutic Potential of Propolis in Ulcerative Colitis: A Review of Preclinical Evidence

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
This review compiles preclinical evidence from studies that investigate the therapeutic potential of propolis extracts derived from different botanical origins, as well as their main bioactive constituents, in the context of ulcerative colitis. The observed beneficial effects are primarily attributed to their antioxidant, immunomodulatory, and anti ...
Thayná Fernandes Barros, Gabriel Gomes Vila Nova, Rosane Nassar Meireles Guerra, Flavia Raquel Fernandes do Nascimento, Afonso Gomes Abreu   +4 more
wiley   +1 more source

Probe Cytotoxic and Oxidative Stress Effects of Nanoplastics on Caco-2 Cells: Insights from Raman Spectroscopy and Machine Learning. [PDF]

Sensors (Basel)
Gustafson B, Kosari N, Brothersen E, Mosher M, Zhou A.   +4 more
europepmc   +1 more source

Physiologically Based Pharmacokinetic Modeling to Assess Transporter‐Mediated Drug–Drug Interactions in Support of Labeling Recommendations for Zavegepant Nasal Spray

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1402-1413, November 2026.
Zavegepant nasal spray, a calcitonin gene‐related peptide receptor antagonist indicated for acute treatment of migraine with or without aura in adults, is a substrate for organic anion transporting polypeptide 1B3 (OATP1B3), Na+/taurocholate cotransporting polypeptide (NTCP), P‐glycoprotein (P‐gp), and cytochrome P450 3A4 (CYP3A4).
Alice Ke, Ernesto Callegari, Manthena V.S. Varma, Mayur K Ladumor, Chieko Muto, Richard J. Bertz, Hannah M. Jones, Vaishali Sahasrabudhe, Jing Liu   +8 more
wiley   +1 more source

The effects of β-caryophyllene on butyrate utilization and metabolism in Caco-2 cells. [PDF]

Sci Rep
Scroggins H, Kent-Dennis C, May J, Harmon DL, Klotz JL.   +4 more
europepmc   +1 more source

Advances in New Approach Methodologies at FDA's Division of Applied Regulatory Science

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1250-1254, November 2026.
New Approach Methodologies (NAMs) represent a paradigm shift in drug development and regulatory science, offering human‐relevant alternatives to traditional preclinical models. This mini‐review highlights recent advances in NAM development, validation, and regulatory application from FDA's Division of Applied Regulatory Science (DARS).
Ksenia Blinova, Kimberly Chiu, Anik Chaturbedi, Jahan Cooper, Tromondae K. Feaster, Paula L. Hyland, Lidiya Stavitskaya, Wendy W. Wu, Jeffry Florian, Rodney Rouse   +9 more
wiley   +1 more source

Association of IBS-associated E. coli strains with epithelial inflammatory responses and tight junction dysregulation in Caco-2 cells. [PDF]

BMC Res Notes
Merzaei Z, Kazemian H, Bamzadeh Z, Paknejadi M, Kouhsari E.   +4 more
europepmc   +1 more source

From Prediction to Decision Making: PBPK and QSP as Regulatory‐Grade NAMs

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1195-1207, November 2026.
New approach methodologies (NAMs) encompass a diverse and rapidly evolving set of experimental and computational tools designed to generate human‐relevant mechanistic data for use in drug development and regulatory decision making. Experimental NAMs provide insights into drug disposition, pharmacological activity, and disease biology that are difficult
Karen Rowland Yeo, Piet H. van der Graaf
wiley   +1 more source

Individual and Combined Effects of Commercial Glyphosate and Dicamba-Based Herbicide Formulations on Cytotoxicity, Oxidative Stress and Cell Death on Human Intestinal Caco-2 Cells. [PDF]

J Xenobiot
Garcia GPJ, Schiebel CS, Vicentini M, Maria-Ferreira D, Guiloski IC.   +4 more
europepmc   +1 more source

Epigenetic silencing of PDLIM4 promotes colorectal cancer by impairing BTF3 autophagic degradation and activating PI3K/Akt signalling

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
• DNMT3A‐mediated PDLIM4 promoter hypermethylation is an early event in colorectal tumorigenesis. • Restoring PDLIM4 suppresses CRC proliferation and stemness while promoting apoptosis in vitro and in vivo. • PDLIM4 promotes the autophagic‐lysosomal degradation of BTF3 and restrains PI3K/Akt signalling.
Jiaxing Wang, Chuan‐Guo Guo, Lingyu Qi, Songyuan Hou, Boshen Lin, Tong Ye, Ye Zong, Shutian Zhang, Nan Zhang, Peng Li, Si Liu   +10 more
wiley   +1 more source