Results 121 to 130 of about 54,220 (246)

microRNA‐145‐5p regulates P‐glycoprotein and breast cancer resistance protein in primary human fetal brain endothelial cells

The Journal of Physiology, EarlyView.
Abstract figure legend Drug transporters P‐glycoprotein (P‐gp) and breast cancer resistance protein (BCRP) at the blood–brain barrier (BBB) protect the rapidly developing fetal brain. We investigated the role of microRNA‐145‐5p (miR‐145‐5p) microRNA (miRNA) in regulating these key transporters in primary human fetal brain endothelial cells in vitro. We
Phetcharawan Lye, Enrrico Bloise, Nikola Ivanovski, Lubna Nadeem, Christopher Casciaro, Stephen G. Matthews   +5 more
wiley   +1 more source

Effects of vitamins A and E on eprinomectin transport in Caco-2 cells. [PDF]

Vet Med (Praha)
Gunes Y, Gultekin Y, Dogan O, Anlas C, Ustuner O, Yilmaz N, Bakirel T.   +6 more
europepmc   +1 more source

Fructose Promotes Oxidative Stress, Sphingolipid Remodelling and Transient Intestinal Barrier Dysfunction in Differentiated Caco-2 Cells. [PDF]

Nutrients
Serreli G, Melis MP, Guerriero C, Manis C, Tolle G, Sanna G, Orrù G, Fais S, Caboni P, Deiana M.   +9 more
europepmc   +1 more source

Multiple Pesticides and their Mixtures Tested for Genotoxicity in the Micronucleus Assays on Intestinal Caco-2 Cells. [PDF]

Ann Glob Health
Truzzi F, Tibaldi E, Noferini R, Sgargi D, Panzacchi S, Nardali G, Lorenzini A, Dilloo S, D'Amen E, Gnudi F, Dinelli G, Scheepers PTJ, Mandrioli D.   +12 more
europepmc   +1 more source

Capsaicin Induces G2/M Cell-Cycle Arrest and Impairs Autophagy in Caco-2 Cells: An Exploratory Study. [PDF]

Int J Mol Sci
Sudan H, Passaponti S, Romagnoli R, Cresti L, Gentile M, Frosini M, Aloisi AM.   +6 more
europepmc   +1 more source

Self‐Assembly of Therapeutic Peptides for Enhanced Cancer Therapy: Strategies, Therapeutic Performance, and Future Perspectives

MedComm – Biomaterials and Applications, Volume 5, Issue 4, December 2026.
Therapeutic peptide self‐assembly is governed by multiple non‐covalent interactions, enabling the construction of diverse supramolecular structures. These self‐assembled systems can be engineered through spontaneous self‐assembly of monomers, co‐assembly, or stimulus‐responsive strategies to improve tumor delivery efficiency.
Yuelin Fang, Xue Wan, Shihe Wang, Honglan Dai, Huiling Zeng, Nan Chen, Xinxin Zhang   +6 more
wiley   +1 more source

Aryl Hydrocarbon Receptor Deficiency Impairs Intestinal Barrier Development, While 2'-Fucosyllactose Reduces Paracellular Permeability in Caco-2 Cells. [PDF]

Toxins (Basel)
Madella AM, van Gerven CCE, Sendino Garví E, van Bergenhenegouwen J, Garssen J, Masereeuw R, Overbeek SA.   +6 more
europepmc   +1 more source

Astragaloside IV and Ferroptosis Modulation in Pathological Cardiac Hypertrophy: Current Evidence, an Integrative Hypothesis, and Future Directions

Pharmacology Research &Perspectives, Volume 14, Issue 6, December 2026.
ABSTRACT Pathological cardiac hypertrophy is initially an adaptive response to sustained mechanical, neurohormonal, or metabolic stress; however, it can progress to fibrosis, contractile dysfunction, arrhythmia, and heart failure. Ferroptosis is a type of regulated cell death caused by iron‐dependent phospholipid peroxidation.
Pengbo Liu, Yongzhi Deng
wiley   +1 more source

Ramucirumab induces apoptosis in Caco-2 cells via mitochondrial impairment and caspase activation. [PDF]

Saudi Pharm J
Al-Dogmi AM, Al-Anazi KM, Qamar W, Farah MA.   +3 more
europepmc   +1 more source

Divergent Roles of PIK3C3 in KRAS‐Wild‐Type and KRAS‐Mutant Advanced Colorectal Cancer: Implications for 5‐Fluorouracil Sensitivity and Prognosis

Cancer Medicine, Volume 15, Issue 11, November 2026.
PIK3C3 plays divergent roles in KRAS‐WT and KRAS‐mutant CRCs, viz. targeting PIK3C3 suppresses KRAS/ERK pathway in KRAS‐WT CRC, while enhancing 5‐FU sensitivity in KRAS‐mutant CRC. ABSTRACT Introduction Phosphatidylinositol 3‐kinase catalytic subunit type 3 (PIK3C3) is central to autophagy, which supports cancer adaptation to environmental stresses and
Chien‐An Chu, Nan‐Haw Chow, Jiu‐Yao Wang, Chen Chang, Peng‐Chan Lin, Yu‐Min Yeh, Bo‐Wen Lin, Yi‐Wen Wang, Yun‐Hao Dai, Yi‐Lin Chen, Po‐Chuan Chen, Shang‐Hung Chen, Ren‐Hao Chan, Chung‐Liang Ho, Che‐Wei Hsu, Chung‐Ta Lee   +15 more
wiley   +1 more source