Results 171 to 180 of about 54,220 (246)

Diethylene Glycol‐Linked Ring‐Fused Bis‐Azoles: Target‐Oriented Synthesis, In Silico Screening, and Antitumor Activity

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A series of diethylene glycol‐linked cyclic derivatives with diversity in the heterocyclic motif have been synthesized and screened for antitumor activity. Two bis‐thiazolo[3,2‐a]pyrimidinone derivatives displayed moderate cytotoxicity, high selectivity against hepatocellular carcinoma cells, promising VEGFR2, and remarkable FGFR2 inhibitory activities
Sami A. Al‐Hussain, Abdulrahman S. Alharbi, Zeinab A. Muhammad, Alyaa S. Abdel Halim, Magdi E. A. Zaki, Mark C. Bagley, Refaie M. Kassab   +6 more
wiley   +1 more source

Mulberroside A attenuates H₂O₂‑induced oxidative stress and barrier dysfunction in Caco‑2 cells through Nrf2/HO‑1‑associated antioxidant signaling. [PDF]

Mol Med Rep
Chen J, Huang X, Chen X, Jin W, Lin D.
europepmc   +1 more source

Hitting Coronaviruses Where It Hurts: Antiviral Strategies Targeting Viral Proteins

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Viral proteins represent key vulnerabilities in human coronaviruses (HCoVs). This review outlines inhibitors targeting spike (S), main protease (Mpro), papain‐like protease (PLpro), and RNA‐dependent RNA polymerase (RdRp), mapping chemically diverse strategies that disrupt entry and replication, and provides an integrated view of current candidates ...
Álvaro de la Cruz‐Potenciano, Miguel Maldonado, María‐José Camarasa, Sonia de Castro   +3 more
wiley   +1 more source

Quantification of Macular Carotenoids over a Wide Dynamic Range in Plant Matrices and Caco-2 Cells Using a Single Transferable Analytical Method. [PDF]

Foods
Sutharsan J, Adler L, Jones A, Arcot J.
europepmc   +1 more source

The Protective Effect of Quercetin on Hydrogen Peroxide-Induced Oxidative Damage in Caco-2 Cells Is Enhanced by Its Loading in Mesoporous Silica Nanoparticles. [PDF]

Pharmaceutics
Matadamas-Ortiz A, Di Pierro P, Sorrentino A, Caputo I, Paolella G, Montefusco A, Regalado-González C.   +6 more
europepmc   +1 more source

Valorization of Carménère Grape Pomace: Extraction, Microencapsulation, and Evaluation of the Bioactivity of Polyphenols in Caco-2 Cells. [PDF]

Int J Mol Sci
Valenzuela-Bustamante P, Cornejo P, Nolan N, Concepción-Alvarez A, Bridi R, Rincón-Cervera MÁ, Porras O, de Camargo AC, Arias-Santé MF.   +8 more
europepmc   +1 more source

Transcriptomic comparison of human intestinal organoids and Caco-2 cells in modeling nutrient absorption: insights from infant formula and breast milk. [PDF]

NPJ Sci Food
Wang X, Zhang W, Yang S, Zheng C, Wang Z, Yang G, Huang C, Yao H, Huang K, Yan Y, Jiang S, Sun J, Xie Q, Zhang Y, Li X, Wang H.   +15 more
europepmc   +1 more source

Phenolic Compounds of Grape Pomace Skin Released During SHIME Colonic Fermentation Shape the Transcriptomic Profile of Tight Junctions, Improving the Barrier Properties in Caco-2 Cells. [PDF]

Int J Mol Sci
Hidalgo M, Vera F, Concepción-Alvarez A, Rubio V, Railef B, Meneses-Pacheco J, Moreno M, Oyarzún M, Camargo AC, Bridi R, Fuenzalida K, Gonzales E, Pacheco I, Añazco C, Pulgar R, Porras O.   +15 more
europepmc   +1 more source

Exposure to polystyrene nanoparticles leads to dysfunction in DNA repair mechanisms in Caco-2 cells. [PDF]

Biol Res
Kustra A, Zając M, Bednarczyk P, Maliszewska-Olejniczak K.   +3 more
europepmc   +1 more source

Loganin alleviates oxidative stress-induced apoptosis by modulating mitochondrial function and STAT3 signaling in DSS-induced colitis and H₂O₂-injured Caco-2 cells. [PDF]

Sci Rep
Li G, Zhou S, Zhao X, Cheng Y, Ma Z.
europepmc   +1 more source