Results 201 to 210 of about 54,220 (246)
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The Caco-2 cell monolayer: usefulness and limitations
Expert Opinion on Drug Metabolism & Toxicology, 2008The Caco-2 monolayer has been used extensively for the high-throughput screening of drug permeability and identification of substrates, inhibitors, and inducers of intestinal transporters, especially P-glycoprotein (P-gp). Traditionally, the Caco-2 monolayer is viewed as a single barrier rather than a polarized cell monolayer consisting of metabolic ...
Huadong, Sun +4 more
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Oxidative stress of alternariol in Caco-2 cells
Toxicology Letters, 2014Alternariol (AOH) is a mycotoxin produced by fungus Alternaria. It is found in a wide variety of fruits and cereals products. AOH is able to damage human health. The aim of this study was to evaluate the cytotoxicity of AOH in human colon adenocarcinoma (Caco-2) cells.
Celia, Fernández-Blanco +2 more
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ERGOVALINE MOVEMENT ACROSS CACO-2 CELLS
In Vitro Cellular and Developmental Biology--Animal, 2005Ergovaline's role in the direct causation of fescue toxicosis first requires establishment of its dietary absorption. Therefore, ergovaline movement across human intestinal cells was assessed using Caco-2 cells derived from human colon carcinoma. A pre-equilibrated mixture of ergovaline/ergovalinine (60:40 ratio of isomers) was added to the apical ...
Nancy W, Shappell, David J, Smith
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Cell Biology and Toxicology, 2005
The human intestinal Caco-2 cell line has been extensively used over the last twenty years as a model of the intestinal barrier. The parental cell line, originally obtained from a human colon adenocarcinoma, undergoes in culture a process of spontaneous differentiation that leads to the formation of a monolayer of cells, expressing several ...
Isabella De Angelis, F Zucco, A Stammati
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The human intestinal Caco-2 cell line has been extensively used over the last twenty years as a model of the intestinal barrier. The parental cell line, originally obtained from a human colon adenocarcinoma, undergoes in culture a process of spontaneous differentiation that leads to the formation of a monolayer of cells, expressing several ...
Isabella De Angelis, F Zucco, A Stammati
exaly +4 more sources
Bacteroides fragilis adherence to Caco-2 cells
Anaerobe, 2002The ability of ten Bacteroides fragilis strains isolated from intestinal and non-intestinal infections, normal flora and environment to adhere to human colon carcinoma cells, Caco-2, was examined. The adherence capacity varied among the strains tested from strongly adherent (76-100%) to non- or weakly adherent (0-25%). Negative staining with Indian ink
E O, Ferreira +8 more
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The role of CDX2 in Caco-2 cell differentiation
European Journal of Pharmaceutics and Biopharmaceutics, 2013CDX2 plays a key part in the differentiation of Caco-2 cells, a colon carcinoma derived cell line that undergoes spontaneous differentiation. The effect of CDX2 expression in Caco-2 cells over time in culture has not been studied yet on a genome-wide level.The impact of CDX2 expression on the genomic profile of Caco-2 cells was studied by transducing ...
Natoli Manuela +4 more
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Characteristics of Ceftibuten Uptake into Caco-2 Cells
Pharmaceutical Research, 1994The characteristics of ceftibuten uptake into Caco-2 cells grown in a collagen-coated dish were examined. Ceftibuten showed stereoselective and pH-dependent uptake. The pH-dependency of ceftibuten was more marked than that of cefaclor or cephalexin, but all three antibiotics showed maximal uptake at pH 5.5.
N, Muranushi +3 more
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Modulation of butyrate transport in Caco-2 cells
Naunyn-Schmiedeberg's Archives of Pharmacology, 2008The aim of this study was to investigate the putative influence of some pharmacological agents and drugs of abuse upon the apical uptake of butyrate (BT) into Caco-2 cells. The apical uptake of (14)C-BT by Caco-2 cells was (1) time and concentration dependent, (2) pH dependent, (3) Na(+) independent and Cl(-) dependent, (4) energy dependent, (5 ...
Pedro, Gonçalves +3 more
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EGF Stimulates Polyamine Uptake in Caco-2 Cells
Biochemical and Biophysical Research Communications, 1995We investigated the effects of epidermal growth factor (EGF) on polyamine uptake in Caco-2 cell monolayers. Cells were grown until confluence (day 7) or until differentiation (day 14). Polyamine uptake into Caco-2 cells was stimulated by EGF in a dose-dependent manner. Both basal and EGF-stimulated uptake rates were higher in 7- than in 14-day-old Caco-
V, Milovic +5 more
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Evaluation of an accelerated Caco-2 cell permeability model
Journal of Pharmaceutical Sciences, 2000An accelerated 3-7-day Caco-2 cell permeability model was examined and compared to the traditional 21-25-day model. Caco-2 cell permeability coefficients (P(Caco-2)) of 33 structurally diverse small molecular weight compounds from apical to basolateral (AP-->BL) direction in the accelerated model were approximately twice those in the traditional model.
E, Liang, K, Chessic, M, Yazdanian
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