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CAMSAP2 is required for bridging fiber assembly to ensure mitotic spindle assembly and chromosome segregation in human epithelial Caco-2 cells. [PDF]
PLoS OneNishizawa N +4 more
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Biological Properties of Boletus edulis Extract on Caco-2 Cells: Antioxidant, Anticancer, and Anti-Inflammatory Effects. [PDF]
Antioxidants (Basel)Quero J +7 more
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Manganese transport by caco-2 cells
Biological Trace Element Research, 1999The uptake and transport kinetics of manganese (Mn) were investigated in the human intestinal Caco-2 cell line both from the absorption side (apical to basolateral) and from the exsorption side (basolateral to apical). With regard to the former, transport versus time revealed (as uptake) a biphasic pattern with an initial transient phase followed by ...
G, Leblondel, P, Allain
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Good Caco-2 cell culture practices
Toxicology in Vitro, 2012The human Caco-2 cells differentiate spontaneously in culture forming monolayers of mature intestinal enterocytes which have been used as a model of the intestinal barrier for in vitro toxicology studies. Reproducibility problems often reported in literature have been generally ascribed to different culture-related conditions, such as the type of ...
Natoli Manuela +4 more
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Caco‐2 Cells as a Model for Intestinal Absorption
Current Protocols in Toxicology, 2011AbstractThe Caco‐2 cell system, a well characterized intestinal in vitro model, makes it possible to evaluate the ability of chemicals to cross the intestinal barrier, as well as to study their transport mechanisms. Permeability values estimated with this model correlate well with human in vivo absorption data for many drugs and chemicals.
Isabella De, Angelis, Laura, Turco
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Endogenous lipase activity in Caco-2 cells
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1998Dietary triglycerides, the major precursors of long chain fatty acids (FA), require hydrolysis by pancreatic enzymes prior to their absorption by the small intestine. Although Caco-2 cells are frequently employed for the study of enterocyte lipid metabolism, the presence of an endogenous lipase activity has never been previously reported.
J H, Spalinger +3 more
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ERGOVALINE MOVEMENT ACROSS CACO-2 CELLS
In Vitro Cellular and Developmental Biology--Animal, 2005Ergovaline's role in the direct causation of fescue toxicosis first requires establishment of its dietary absorption. Therefore, ergovaline movement across human intestinal cells was assessed using Caco-2 cells derived from human colon carcinoma. A pre-equilibrated mixture of ergovaline/ergovalinine (60:40 ratio of isomers) was added to the apical ...
Nancy W, Shappell, David J, Smith
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The Caco-2 cell monolayer: usefulness and limitations
Expert Opinion on Drug Metabolism & Toxicology, 2008The Caco-2 monolayer has been used extensively for the high-throughput screening of drug permeability and identification of substrates, inhibitors, and inducers of intestinal transporters, especially P-glycoprotein (P-gp). Traditionally, the Caco-2 monolayer is viewed as a single barrier rather than a polarized cell monolayer consisting of metabolic ...
Huadong, Sun +4 more
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The role of CDX2 in Caco-2 cell differentiation
European Journal of Pharmaceutics and Biopharmaceutics, 2013CDX2 plays a key part in the differentiation of Caco-2 cells, a colon carcinoma derived cell line that undergoes spontaneous differentiation. The effect of CDX2 expression in Caco-2 cells over time in culture has not been studied yet on a genome-wide level.The impact of CDX2 expression on the genomic profile of Caco-2 cells was studied by transducing ...
Natoli Manuela +4 more
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