Results 11 to 20 of about 3,724 (147)

NOTCH3 CADASIL Variant Receptor Aggregation Requires NOTCH3 Wild-Type Receptors: Identification of Highly Selective Inhibitors That Block the Process. [PDF]

FASEB J
CADASIL is the major cause of early‐onset stroke and cognitive dysfunction, including dementia. It is caused by mutations in the NOTCH3 receptor that result in the formation of protein aggregates in the small vessel walls of the brain. We demonstrated that NOTCH3 CADASIL variant receptor aggregation is strictly dependent on interactions with NOTCH3 ...
Wang H, Liu X, Gravesteijn G, Atella A, Liu J, Rutten JW, Ten Dijke P, Gonçalves MAFV, Lesnik Oberstein SAJ, Baker DA.   +9 more
europepmc   +2 more sources

Vascular smooth muscle cell loss, but not neuroinflammation, drives cerebrovascular reactivity impairment in Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Cerebrovascular reactivity (CVR) impairment is a key feature of Alzheimer's disease and related dementias (ADRD), but its mechanistic basis remains unclear. This study examined whether vascular smooth muscle cell (VSMC) loss, rather than amyloidosis or neuroinflammation, underlies CVR deficits.
Yang X, Li Y, Yao M, Bibic A, Duan W, Lu H, Wei Z.   +6 more
europepmc   +2 more sources

Comorbidity Between Recurrent Major Depressive Disorder and CADASIL: A Case Report With a Brief Review of Published Cases. [PDF]

Clin Case Rep
ABSTRACT Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) may underlie mood disorders by directly affecting cerebral vascular function and neural networks, thereby contributing to or worsening mood symptoms.
Wang YM, Yu HY, Zhang L, Hu C.
europepmc   +2 more sources

Assessment of Small Vessel Density Changes in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalophy (CADASIL) by High-Resolution Black-Blood MRI. [PDF]

J Magn Reson Imaging
ABSTRACT Background Direct assessments of cerebral small vessels in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) remain a challenge. Purpose To investigate changes of cerebral small vessels in CADASIL using iso‐0.5 mm black‐blood MRI. Study Type Case control study.
Yang Z, Guo F, Mendoza S, Huang Z, Li Y, Ying Y, Cheng X, Yang Q, Shi Y, Wang DJJ.   +9 more
europepmc   +2 more sources

Management of Coronary Artery Disease in CADASIL Patients: Review of Current Literature

Medicina, 2023
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common heritable form of vascular dementia in adults.
Maria Servito, Isha Gill, Joshua Durbin, Nader Ghasemlou, Aron-Frederik Popov, Christopher D. Stephen, Mohammad El-Diasty   +6 more
doaj   +1 more source

Identification of a known mutation in Notch 3 in familiar CADASIL in China. [PDF]

PLoS ONE, 2012
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited disease leading to recurrent ischemic stroke and vascular dementia.
Zhen-Xuan Tan, Fei-Feng Li, You-Yang Qu, Ji Liu, Gui-Rong Liu, Jin Zhou, Yu-Lan Zhu, Shu-Lin Liu   +7 more
doaj   +1 more source

PSMD‐2: A fully automated marker for longitudinal assessment of cerebrovascular white matter injury [PDF]

Alzheimers Dement
Abstract Background Cerebral small vessel disease (SVD) is highly prevalent in older adults and a key comorbidity in neurodegenerative conditions such as Alzheimer's disease. While conventional MRI markers (e.g. white matter hyperintensities) capture late SVD stages, diffusion MRI metrics are sensitive to early SVD‐related brain changes, making them ...
Dewenter A, Gesierich B, Kopczak A, Oberstein S, Rutten J, Gravesteijn G, Franzmeier N, Markus H, Duering M.   +8 more
europepmc   +4 more sources

Effect of corticosubcortical iron deposition on dysfunction in CADASIL is mediated by white matter microstructural damage

NeuroImage: Clinical, 2023
Iron dysregulation may attenuate cognitive performance in patients with CADASIL. However, the underlying pathophysiological mechanisms remain incompletely understood. Whether white matter microstructural changes mediate these processes is largely unclear.
Xiuqin Jia, Yingying Li, Yunqing Ying, Xuejia Jia, Weijun Tang, Yueyan Bian, Jiajia Zhang, Danny J.J. Wang, Xin Cheng, Qi Yang   +9 more
doaj   +1 more source

A Case of CADASIL with NOTCH3 Gene Mutation Presenting with Focal Epileptic Seizure: A Case of CADASIL Presenting with Focal Epileptic Seizure

Archives of Epilepsy, 2023
CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is a hereditary disease of cerebral microvessels with autosomal dominant inheritance due to the NOTCH3 gene mutation. Epileptic seizures were observed in
Gülgün Uncu, Demet İlhan Algın, Oğuz Osman Erdinç, Demet Özbabalık Adapınar   +3 more
doaj   +1 more source

The first report of CADASIL in Peru: Olfactory dysfunction on initial presentation

eNeurologicalSci, 2016
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) is a rare, heritable, small vessel vascular disease caused by mutations in the Notch3 gene that is characterized by migraines, subcortical vascular ...
Anastasia Vishnevetsky, Miguel Inca-Martinez, Karina Milla-Neyra, Danny Moises Barrientos-Iman, Ivan Cornejo-Herrera, Carlos Cosentino, Mario Cornejo-Olivas   +6 more
doaj   +1 more source