Results 11 to 20 of about 9,876 (239)

Inducing mononuclear cells of patients with CADASIL to construct a CSVD disease model [PDF]

European Journal of Medical Research
Objective To produce pluripotent stem cells from peripheral blood mononuclear cells (PBMCs) of a patient with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and culture and differentiate them into ...
Zhiqiang Wang, Jianjian Yin, Wa Chao, Xiaoning Zhang   +3 more
doaj   +2 more sources

Novel mutation of the NOTCH3 gene in Arabic family with CADASIL [PDF]

Neurology International, 2011
Mutations in the NOTCH3 gene are responsible for cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), an adult onset hereditary angiopathy leading to ischemic stroke, vascular dementia and psychiatric ...
Saeed Bohlega
doaj   +4 more sources

Is migraine a common manifestation of CADASIL-Cons [PDF]

The Journal of Headache and Pain
Headaches and transient neurological symptoms that bear resemblances to clinical manifestations of migraine, especially migraine with aura, are common among patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and ...
Yen-Feng Wang
doaj   +2 more sources

Cerebrovascular Function in Sporadic and Genetic Cerebral Small Vessel Disease. [PDF]

Ann Neurol
Objective Cerebral small vessel diseases (SVDs) are associated with cerebrovascular dysfunction, such as increased blood–brain barrier leakage (permeability surface area product), vascular pulsatility, and decreased cerebrovascular reactivity (CVR). No studies assessed all 3 functions concurrently.
Stringer MS, Blair GW, Kopczak A, Kerkhofs D, Thrippleton MJ, Chappell FM, Maniega SM, Brown R, Shuler K, Hamilton I, Garcia DJ, Doubal FN, Clancy U, Sakka E, Poliakova T, Janssen E, Duering M, Ingrisch M, Staals J, Backes WH, van Oostenbrugge R, Biessels GJ, Dichgans M, Wardlaw JM, SVDs@target consortium.   +24 more
europepmc   +2 more sources

Imaging brain fluid dynamics and waste clearance involving perivascular spaces in cerebral small vessel disease. [PDF]

Alzheimers Dement
Abstract Cerebral small vessel disease (SVD) is recognized as a major vascular contributor to cognitive decline, ultimately leading to dementia and stroke. While the pathogenesis of SVD remains unclear, emerging evidence suggests that waste clearance involving perivascular space (PVS) – also known as the glymphatic system – dysfunction may play a role.
Solé-Guardia G, Li H, Willemse L, Lebenberg J, Jouvent E, Tuladhar AM.   +5 more
europepmc   +2 more sources

Novel NOTCH3 mutation c.1564 T > A (p.Cys522Ser) presenting with early-onset Parkinsonism and white matter lesions [PDF]

Clinical Parkinsonism & Related Disorders
CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a hereditary small vessel disease caused by mutations in the NOTCH3 gene, characterized by recurrent strokes, cognitive decline, and psychiatric ...
Nicola Rifino, Silvia Baratta, Esteban Zacarias, Isabella Canavero, Benedetta Storti, Mario Stanziano, Emanuela Maderna, Gianluca Marucci, Franco Taroni, Anna Bersano   +9 more
doaj   +2 more sources

Mechanisms of Cognitive Impairment in Cerebral Small Vessel Disease: Multimodal MRI Results from the St George's Cognition and Neuroimaging in Stroke (SCANS) Study. [PDF]

, 2013
Cerebral small vessel disease (SVD) is a common cause of vascular cognitive impairment. A number of disease features can be assessed on MRI including lacunar infarcts, T2 lesion volume, brain atrophy, and cerebral microbleeds.
A Nitkunan, A Nitkunan, A Viswanathan, A Zhou, Andrew D. MacKinnon, Andrew J. Lawrence, AZ Burzynska, B Grassiot, B Patel, Bhavini Patel, C Cordonnier, C Junqué, CAM Wheeler-Kingshott, CM Fisher, DJ Werring, E Englund, EE Smith, EE Smith, F Fazekas, Hugh S. Markus, IA Awad, J Bamford, J Grimaud, JC van Swieten, Jean-Claude Baron, L Pantoni, M Duering, M Holtmannspötter, M Jenkinson, M Neeman, M O'Sullivan, M O'Sullivan, M O'Sullivan, N Shiee, Philip M. Rich, PJ Basser, PS Sachdev, R Della Nave, R Schmidt, RA Charlton, RA Charlton, Robin G. Morris, SK Song, SM Smith, SW Seo, Thomas R. Barrick, U Khan, Y Nagahama   +47 more
core   +19 more sources

Induced pluripotent stem cell model revealed impaired neurovascular interaction in genetic small vessel disease Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

Frontiers in Cellular Neuroscience, 2023
IntroductionCerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is the most common genetic small vessel disease caused by variants in the NOTCH3 gene.
Wenjun Zhang, Xiangjun Zhao, Xuewei Qi, Susan J. Kimber, Nigel M. Hooper, Nigel M. Hooper, Tao Wang, Tao Wang, Tao Wang   +8 more
doaj   +1 more source

Neuroimaging Characteristics of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) in Korean Based on Jeju Cohort: A Pictorial Essay

Journal of the Korean Society of Radiology, 2023
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary small artery vasculopathy caused by mutations in the NOTCH3 gene on chromosome 19.
Yeh Rin Suh, Ho Kyu Lee, Kyeong Ho Jung, Jung Seok Lee, Jay Chol Choi   +4 more
doaj   +1 more source

Human iPS cell-derived mural cells as an in vitro model of hereditary cerebral small vessel disease

Molecular Brain, 2020
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is one of the most common forms of hereditary cerebral small vessel diseases and is caused by mutations in NOTCH3.
Yumi Yamamoto, Katsutoshi Kojima, Daisuke Taura, Masakatsu Sone, Kazuo Washida, Naohiro Egawa, Takayuki Kondo, Eiko N. Minakawa, Kayoko Tsukita, Takako Enami, Hidekazu Tomimoto, Toshiki Mizuno, Raj N. Kalaria, Nobuya Inagaki, Ryosuke Takahashi, Mariko Harada-Shiba, Masafumi Ihara, Haruhisa Inoue   +17 more
doaj   +1 more source