Results 31 to 40 of about 10,883 (231)

CADASIL Argentine Registry: Study Design and Preliminary Data [PDF]

Alzheimers Dement
Abstract Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the most common hereditary small vessel disease, leads to early‐onset stroke and vascular cognitive impairment (VCI). Despite its importance, data from Latin America remain scarce.
Cristalli C, Rosales J, Gonzalez F, Selvaggi V, Alonso J, López J, Aguilar M, Kauffman M, Saks D, Allegri R, Sevlever G, Chaves H, Cristalli D, Calandri I.   +13 more
europepmc   +2 more sources

A Nationwide Survey and Multicenter Registry-Based Database of Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy in Japan

Frontiers in Aging Neuroscience, 2020
ObjectivesClinical characteristics of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) include migraine, recurrent stroke, white matter lesions, and vascular dementia.
Akihiro Shindo, Ken-ichi Tabei, Akira Taniguchi, Hiroaki Nozaki, Osamu Onodera, Akihiko Ueda, Yukio Ando, Yukio Ando, Takao Urabe, Kazumi Kimura, Kazuo Kitagawa, Haruo Hanyu, Teruyuki Hirano, Hideaki Wakita, Hidenao Fukuyama, Tatsuo Kagimura, Yoshihiro Miyamoto, Misa Takegami, Satoshi Saito, Akiko Watanabe-Hosomi, Ikuko Mizuta, Masafumi Ihara, Toshiki Mizuno, Hidekazu Tomimoto   +23 more
doaj   +1 more source

Recurrent generalized seizures as the prominent manifestation in a patient with CADASIL: a case report and literature review

BMC Neurology, 2022
Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited arteriopathy typically caused by mutations in the NOTCH-3 gene. Few detailed descriptions of recurrent generalized seizures in
Liuhua Pan, Yan Chen, Shanshan Zhao
doaj   +1 more source

Incipient CADASIL [PDF]

Archives of Neurology, 2003
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by mutations in the NOTCH3 gene. Knowledge of disease expression in young adult NOTCH3 mutation carriers (MCs) is limited.To characterize clinical, neuropsychological, and radiological status in NOTCH3 MCs younger than 35 years.Clinical ...
Saskia A J, Lesnik Oberstein, Rivka, van den Boom, Huub A M, Middelkoop, Michel D, Ferrari, Yvette M, Knaap, Hans C, van Houwelingen, Martijn H, Breuning, Mark A, van Buchem, Joost, Haan   +8 more
openaire   +2 more sources

Identification of a known mutation in Notch 3 in familiar CADASIL in China. [PDF]

PLoS ONE, 2012
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited disease leading to recurrent ischemic stroke and vascular dementia.
Zhen-Xuan Tan, Fei-Feng Li, You-Yang Qu, Ji Liu, Gui-Rong Liu, Jin Zhou, Yu-Lan Zhu, Shu-Lin Liu   +7 more
doaj   +1 more source

Management of Coronary Artery Disease in CADASIL Patients: Review of Current Literature

Medicina, 2023
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common heritable form of vascular dementia in adults.
Maria Servito, Isha Gill, Joshua Durbin, Nader Ghasemlou, Aron-Frederik Popov, Christopher D. Stephen, Mohammad El-Diasty   +6 more
doaj   +1 more source

Effect of corticosubcortical iron deposition on dysfunction in CADASIL is mediated by white matter microstructural damage

NeuroImage: Clinical, 2023
Iron dysregulation may attenuate cognitive performance in patients with CADASIL. However, the underlying pathophysiological mechanisms remain incompletely understood. Whether white matter microstructural changes mediate these processes is largely unclear.
Xiuqin Jia, Yingying Li, Yunqing Ying, Xuejia Jia, Weijun Tang, Yueyan Bian, Jiajia Zhang, Danny J.J. Wang, Xin Cheng, Qi Yang   +9 more
doaj   +1 more source

Investigating the effects of NOTCH3 Asian‐specific mutant on blood‐brain‐barrier using patient iPSC‐derived cell types [PDF]

Alzheimers Dement
Abstract Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), is the genetic form of vascular dementia leading to vascular impairments and cognitive decline. CADASIL is caused by mutations in the NOTCH3 gene which encodes a single‐pass transmembrane receptor. The NOTCH3 mutant (MT) is reported
Lee J, Ng A, Tan E, Zeng L.
europepmc   +2 more sources

A Case of CADASIL with NOTCH3 Gene Mutation Presenting with Focal Epileptic Seizure: A Case of CADASIL Presenting with Focal Epileptic Seizure

Archives of Epilepsy, 2023
CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is a hereditary disease of cerebral microvessels with autosomal dominant inheritance due to the NOTCH3 gene mutation. Epileptic seizures were observed in
Gülgün Uncu, Demet İlhan Algın, Oğuz Osman Erdinç, Demet Özbabalık Adapınar   +3 more
doaj   +1 more source

NIHSS Scores in Ischemic Small Vessel Disease: A Study in CADASIL [PDF]

, 2012
Background: The National Institutes of Health Stroke Scale (NIHSS) is widely used to measure neurological deficits, evaluate the effectiveness of treatment and predict outcome in acute ischemic stroke.
Allili, Nassira, Chabriat, Hugues, Dichgans, Martin, Duering, Marco, Herve, Dominique, Jouvent, Eric, Yao, Ming   +6 more
core   +1 more source