Results 31 to 40 of about 3,724 (147)

Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model

EMBO Molecular Medicine, 2022
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic form of familial small vessel disease; no preventive or curative therapy is available. CADASIL is caused by mutations in the
Daniel V Oliveira, Kirsten G Coupland, Wenchao Shao, Shaobo Jin, Francesca Del Gaudio, Sailan Wang, Rhys Fox, Julie W Rutten, Johan Sandin, Henrik Zetterberg, Johan Lundkvist, Saskia AJ Lesnik Oberstein, Urban Lendahl, Helena Karlström   +13 more
doaj   +1 more source

Reduced macular vessel density and inner retinal thickness correlate with the severity of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

PLoS ONE, 2022
BackgroundCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), caused by mutations in NOTCH3, is the most common cause of hereditary cerebral small vessel disease.
Chao-Wen Lin, Zih-Wei Yang, Chih-Hao Chen, Yu-Wen Cheng, Sung-Chun Tang, Jiann-Shing Jeng   +5 more
doaj   +1 more source

CADASIL

Revista Médica del Uruguay, 2008
Introducción: el síndrome CADASIL (Cerebral Dominant Arteriopathy with Subcortical Infarcts and Leukoencephlopathy) es una microangiopatía no amiloidea, no ateromatosa que se transmite en forma autosómica dominante y cuyas principales manifestaciones clínicas ocurren a nivel cerebral.
Alicia Vaglio, Marnels Ferreira, Ana Luisa Panuncio, María Antonia Castagnola, Matías Pebet, Soledad De la Peña, Roberto Quadrelli   +6 more
openaire   +3 more sources

De novo mutation in the NOTCH3 gene causing CADASIL

Biomolecules & Biomedicine, 2014
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) is one of the most common hereditary forms of stroke, and migraine with aura, mood disorders and dementia.
Dragan Stojanov, Danijela Grozdanović, Sladjana Petrović, Daniela Benedeto-Stojanov, Ivan Stefanović, Nebojša Stojanović, Dušica N. Ilić   +6 more
doaj   +1 more source

Sex differences in frontotemporal atrophy in CADASIL revealed by 7-Tesla MRI

NeuroImage: Clinical, 2023
Brain damage caused by small vessel disease (SVD) differs between males and females. We aimed to examine the pure sex-specific neuroanatomical mechanisms of SVD adjusted for voxel-based expected effects of age and sex on healthy brain volume.
Xiuqin Jia, Chen Ling, Yingying Li, Jinyuan Zhang, Zhixin Li, Xuejia Jia, Danny J.J. Wang, Zihao Zhang, Yun Yuan, Qi Yang   +9 more
doaj   +1 more source

Psychotherapy and inhibitory control: Insights from fMRI research

Psychiatry and Clinical Neurosciences, EarlyView.
Aim Despite the widespread clinical use of psychotherapy, the neural mechanisms linking treatment to changes in inhibitory control networks supporting self‐regulation remain unclear. This study addresses this gap by meta‐analyzing neuroimaging research on how psychotherapy affects brain regions involved in inhibitory control.
Gioele Gavazzi, Ozge Ozkan, Viola Benedetti, Fabio Giovannelli, Valdo Ricca, Maria Pia Viggiano   +5 more
wiley   +1 more source

Mechanistic advances in factors influencing phenotypic variability in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: a review

Frontiers in Neurology
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic cerebral small-vessel disease caused by mutations in NOTCH3 and is the most common hereditary cerebral small-vessel disease in adults. The
Ying Zhao, YaRu Lu, FengYu Wang, YaDan Wang, YaQiong Li, RuiHua Sun, JunKui Shang, Chao Jiang, Jiewen Zhang   +8 more
doaj   +1 more source

Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells

Protein & Cell, 2019
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare hereditary cerebrovascular disease caused by a NOTCH3 mutation.
Chen Ling, Zunpeng Liu, Moshi Song, Weiqi Zhang, Si Wang, Xiaoqian Liu, Shuai Ma, Shuhui Sun, Lina Fu, Qun Chu, Juan Carlos Izpisua Belmonte, Zhaoxia Wang, Jing Qu, Yun Yuan, Guang-Hui Liu   +14 more
doaj   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

An unusual case of cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy with occipital lobe involvement

Annals of Indian Academy of Neurology, 2016
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an autosomal dominant angiopathy caused by a mutation in the notch 3 gene on chromosome 19.
Bhavesh Trikamji, Mariam Thomas, Gasser Hathout, Shrikant Mishra   +3 more
doaj   +1 more source