PLoS ONE, 2022 BackgroundCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), caused by mutations in NOTCH3, is the most common cause of hereditary cerebral small vessel disease.
Chao-Wen Lin +5 more
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Small Vessel Disease in the Heart and Brain: Current Knowledge, Unmet Therapeutic Need and Future Directions [PDF]
, 2019 No abstract ...
Berry, C +6 more
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Neuronal densities and vascular pathology in the hippocampal formation in CADASIL [PDF]
, 2021 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common form of hereditary cerebral small vessel disease. Previous neuroimaging studies have suggested loss of hippocampal volume is a pathway
Duering, Marco +6 more
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ER stress and Rho kinase activation underlie the vasculopathy of CADASIL [PDF]
, 2019 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) leads to premature stroke and vascular dementia. Mechanism-specific therapies for this aggressive cerebral small vessel disease are lacking.
Alves-Lopes, Rhéure +11 more
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De novo mutation in the NOTCH3 gene causing CADASIL
Biomolecules & Biomedicine, 2014 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) is one of the most common hereditary forms of stroke, and migraine with aura, mood disorders and dementia.
Dragan Stojanov +6 more
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Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL): Three case reports from Serbia [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2008 Introduction Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary microangiopathy leading to recurrent strokes and vascular dementia in young and middleaged patients.
Zidverc-Trajković Jasna +9 more
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Stroke, 2009 CADASIL is an early onset small vessel disease and genetic variant of pure subcortical ischemic vascular dementia (SIVD). The condition has been invaluable in defining the profile and neuroimaging correlates of cognitive deficits in pure SIVD. The recent completion of a randomized trial in cognitively impaired CADASIL patients has illustrated the ...
openaire +2 more sources
Differences in proliferation rate between CADASIL and control vascular smooth muscle cells are related to increased TGF beta expression [PDF]
, 2018 Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a familial fatal progressive degenerative disorder.
Behbahani, Homira +11 more
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Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model
EMBO Molecular Medicine, 2022 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic form of familial small vessel disease; no preventive or curative therapy is available. CADASIL is caused by mutations in the
Daniel V Oliveira +13 more
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Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells
Protein & Cell, 2019 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare hereditary cerebrovascular disease caused by a NOTCH3 mutation.
Chen Ling +14 more
doaj +1 more source