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Depression in CADASIL patients [PDF]
Archives of Biological Sciences, 2014 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary neurological disease accompanied by recurrent ischemic events, characterized by the presence of psychiatric disorders.
Lačković Maja +8 more
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A heterozygous mutation in NOTCH3 in a Chinese family with CADASIL
Frontiers in Genetics, 2022 Introduction: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an autosomal-dominant systemic vascular disease that primarily involves small arteries.
Juyi Li +10 more
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Voxel‐Wise Whole‐Brain Analysis in Quantitative Susceptibility Mapping: A Narrative Review
Human Brain Mapping, Volume 47, Issue 3, 15 February 2026.Voxel‐wise QSM enables the detection of subtle susceptibility changes and the exploration of disease associations without relying on predefined regions, making it a valuable tool for studying aging and neurological disorders. This review summarizes the complete workflow of voxel‐wise QSM, highlighting post‐processing steps, key methodological ...
Ying Tang +4 more
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Stroke, 2009 CADASIL is an early onset small vessel disease and genetic variant of pure subcortical ischemic vascular dementia (SIVD). The condition has been invaluable in defining the profile and neuroimaging correlates of cognitive deficits in pure SIVD. The recent completion of a randomized trial in cognitively impaired CADASIL patients has illustrated the ...
openaire +2 more sources
Arquivos de Neuro-Psiquiatria, 2015 CADASIL is the most common cause of hereditary stroke and vascular dementia. Published information about this disease in South America is scant. We describe clinical and demographic characteristics of 13 patients (10 families) with CADASIL from Argentina.
Maximiliano A Hawkes +7 more
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Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract INTRODUCTION While brain iron accumulation has been linked to cognitive impairment in aging and small vessel diseases, its spatial pattern and clinical significance in cerebral amyloid angiopathy (CAA) remain poorly defined. METHODS Quantitative susceptibility mapping (QSM) was used to assess region‐specific iron deposition across cortical ...
Yijun Lin +7 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.This study developed an integrated nomogram combining QSM‐based radiomics, brain iron deposition, white matter hyperintensity, and clinical markers. This model demonstrated superior performance in stratifying hypertensive cognitive impairment compared to traditional single‐parameter models.
Yu Su +12 more
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Brain and Behavior, Volume 16, Issue 1, January 2026.This bibliometric study systematically analyzed 1074 publications in the field of CSVD‐CI from 2001 to 2024. The research reveals three evolutionary phases and identifies four core research clusters: pathophysiological mechanisms, neuroimaging biomarkers, clinical assessment, and therapeutic interventions.
Kuihua Wang +10 more
wiley +1 more source
Brain Pathology, Volume 36, Issue 1, January 2026.Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li +7 more
wiley +1 more source
Is migraine a common manifestation of CADASIL? Arguments Pros
The Journal of Headache and PainBackground Migraine with aura (MA) is a hallmark feature of CADASIL, a hereditary small-vessel disease caused by NOTCH3 mutations. While MA is prevalent in CADASIL, its underlying mechanisms remain unclear, and the links observed can be questioned or ...
Hugues Chabriat
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