Results 91 to 100 of about 100,650 (200)

Serum metabolic and microbial profiling yields insights into promoting effect of tryptophan‐related metabolites for health longevity in centenarians

iMeta, EarlyView.
Schematic representation of the design. Tryptophan metabolism is enriched in serum metabolites and gut microbiota of centenarians, potentially contributing to healthy longevity. A key tryptophan metabolite 5‐methoxyindoleacetic acid (5‐MIAA) is linked to the Christensenellaceae R‐7 group and exhibits effects of delaying cell senescence, promoting ...
Xiaorou Qiu, Chao Mu, Jie Hu, Jiaxin Yu, Wenbo Tang, Yueli Liu, Yongmei Huang, Yixian Lu, Peihua Tang, Jingzhen Wu, Zixuan Huang, Xianlin Mei, Huaguo Xiang, Hao Lin, Yi Qi, Hui Luo, Xuemeng Li   +16 more
wiley   +1 more source

Mid‐IR Imaging Can Detect Waste Heat Production in the Nematode Caenorhabditis elegans

Journal of Biophotonics, EarlyView.
This study explores how the ectothermic invertebrate Caenorhabditis elegans produces waste heat during metabolism using thermal infrared imaging. A new imaging technique was developed to clearly show differences in heat output between living and dead worms.
Ryan A. Merritt, Kegan Heaney, Nuren Shuchi, Kacy L. Gordon, Susan R. Trammell   +4 more
wiley   +1 more source

Symmetry breakage in the development of one-armed gonads in nematodes [PDF]

, 1996
Whereas the hermaphrodite gonad of Caenorhabditis elegans has two symmetric arms (didelphy), the female/hermaphrodite gonad of many nematode species features a single anterior arm (monodelphy).
Félix, Marie-Anne, Sternberg, Paul W.
core  

Organogenesis of the Caenorhabditis elegans Intestine

Developmental Biology, 1999
The intestine of Caenorhabditis elegans is an epithelial tube consisting of only 20 cells and is derived clonally from a single embryonic blastomere called E. We describe the cellular events that shape the intestine. These events include cytoplasmic polarization of cells in the intestinal primordium, the intercalation of specific sets of cells, the ...
Ben Leung, James R Priess, Greg J. Hermann, Greg J. Hermann   +3 more
openaire   +3 more sources

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Nucleologenesis in the Caenorhabditis elegans Embryo

PLoS ONE, 2012
In the Caenorhabditis elegans nematode, the oocyte nucleolus disappears prior to fertilization. We have now investigated the re-formation of the nucleolus in the early embryo of this model organism by immunostaining for fibrillarin and DAO-5, a putative NOLC1/Nopp140 homolog involved in ribosome assembly.
Christian Lanctôt, Adriána Gombitová, Dušan Cmarko, Darina Korčeková, Ivan Raška   +4 more
openaire   +5 more sources

Multiomics Reveal Associations Between CpG Methylation, Histone Modifications and Transcription in a Species That has Lost DNMT3, the Colorado Potato Beetle

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Despite lacking DNMT3, EM‐seq revealed CpG methylation in the Colorado potato beetle. CUT&Tag analysis showed an association of H3K36me3 and H3K27ac with transcription, with H3K36me3 mirroring CpG methylation, demonstrating epigenetic flexibility.
Zoe M. Länger, Elisa Israel, Jan Engelhardt, Agata I. Kalita, Claudia I. Keller Valsecchi, Joachim Kurtz, Sonja J. Prohaska   +6 more
wiley   +1 more source

Untwisting the Caenorhabditis elegans embryo

eLife, 2015
The nematode Caenorhabditis elegans possesses a simple embryonic nervous system with few enough neurons that the growth of each cell could be followed to provide a systems-level view of development. However, studies of single cell development have largely been conducted in fixed or pre-twitching live embryos, because of technical difficulties ...
Daniel A. Colón-Ramos, William A. Mohler, Huafeng Liu, Evan McCreedy, Yicong Wu, Zhirong Bao, Abhishek Kumar, Abhishek Kumar, Nicole Tashakkori, Peter Winter, Javier Marquina-Solis, Matthew McAuliffe, Ismar Kovacevic, Alexandra Bokinsky, Min Guo, Min Guo, Hari Shroff, Anthony Santella, Ryan Christensen   +18 more
openaire   +4 more sources

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

Medicinal Research Reviews, EarlyView.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni, Giulia Galli, Clelia Dallanoce, Marco De Amici, Pau Gorostiza, Carlo Matera   +5 more
wiley   +1 more source

Neurogenesis in the Nematode Caenorhabditis elegans* [PDF]

WormBook, 2010
The nervous system represents the most complex tissue of C. elegans both in terms of numbers (302 neurons and 56 glial cells = 37% of the somatic cells in a hermaphrodite) and diversity (118 morphologically distinct neuron classes). The lineage and morphology of each neuron type has been described in detail and neuronal fate markers exists for ...
openaire   +3 more sources