Results 131 to 140 of about 100,650 (200)
Aged Gut Microbiota Contributes to Cognitive Impairment and Hippocampal Synapse Loss in Mice
Aging Cell, EarlyView.Li et al. revealed that aged gut microbiota induces cognitive decline and microglia‐mediated synapse loss. Fecal Bifidobacterium pseudolongum abundance was reduced in patients with cognitive impairment and microbiota transplantation from patients with fewer B.p abundance yielded worse cognitive behavior in mice.
Mingxiao Li +12 more
wiley +1 more source
Aging Cell, EarlyView.Metformin and dietary restriction modulate m6A to extend lifespan of rotifer, highlighting MTR as a central regulator of aging through methionine metabolism. ABSTRACT Metformin, a medication primarily used to treat diabetes, has gained attentions for its potential antiaging properties.
Yu Zhang +8 more
wiley +1 more source
Aging Cell, EarlyView.ElixirSeeker is a machine learning architecture based on a phenotype‐driven drug discovery approach to screen lifespan‐extending compounds. By integrating molecular fingerprints, ElixirSeeker could maximize feature capture of lifespan‐extending compounds.
Yan Pan +15 more
wiley +1 more source
Brain Pathology, EarlyView.Elevated angiogenin levels in skeletal muscle are linked to slower disease progression, enhanced regeneration, and vascularization through satellite‐endothelial interaction during myogenesis in ALS. Angiogenin and its tiRNAs may serve as prognostic markers and therapeutic targets for ALS.
Paola Fabbrizio +13 more
wiley +1 more source
The dark sides of the GPCR tree ‐ research progress on understudied GPCRs
British Journal of Pharmacology, EarlyView.Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf +10 more
wiley +1 more source
G protein‐coupled receptor‐mediated autophagy in health and disease
British Journal of Pharmacology, EarlyView.G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan +2 more
wiley +1 more source
Myonuclear dynamics with age and exercise: shaping up for a good time
, 2023 The Journal of Physiology, EarlyView.
Cory M. Dungan
wiley +1 more source
The pace and shape of ant ageing
Biological Reviews, EarlyView.ABSTRACT Ants have been proposed as good models to study ageing and the effects of extrinsic mortality because of their long lifespans and plasticity of ageing within species. We discuss how age‐dependent extrinsic mortality might influence queen lifespan, and how the effect of age‐independent extrinsic mortality needs further study, accounting for ...
Luisa M. Jaimes‐Nino, Jan Oettler
wiley +1 more source
Cell Proliferation, EarlyView.KB2764 interacted with alpha‐enolase (ENO1) and pyruvate kinase M (PKM), ultimately leading to PKM phosphorylation of ENO1. KB2764 consequently increased mitochondrial ATP production and decreased glycolysis dependence. Furthermore, the action of KB2764 extends its application to extend the lifespan of Caenorhabditis elegans.
Yun Haeng Lee +13 more
wiley +1 more source
Asymmetrical Use of Appendages in Food Probing by Two Ant Species
Ethology, EarlyView.ABSTRACT Lateralization, or the presence of left–right asymmetry, is a widespread phenomenon in vertebrates and has been shown to confer various adaptive advantages, as lateralized individuals tend to outperform non‐lateralized ones in specific tasks. In contrast, much less is known about lateralization in invertebrates.
Alexandra Koch +3 more
wiley +1 more source