Results 71 to 80 of about 193,403 (293)

Measurement of Lysosomal Size and Lysosomal Marker Intensities in Adult Caenorhabditis elegans

Bio-Protocol, 2018
Assays have been developed to study trafficking in various tissues of Caenorhabditis elegans. Adult C. elegans intestinal cells are large and have extensive endocytic networks, thus making them a good system for deciphering the endocytic pathway using ...
Julie Huynh, Hope Dang, Hanna Fares
doaj   +1 more source

A comparison of experience-dependent locomotory behaviors and biogenic amine neurons in nematode relatives of Caenorhabditis elegans [PDF]

, 2010
Background: Survival of an animal depends on its ability to match its responses to environmental conditions. To generate an optimal behavioral output, the nervous system must process sensory information and generate a directed motor output in ...
Loer, Curtis M., Ochoa, Stacy, Rivard, Laura, Srinivasan, Jagan, Sternberg, Paul W., Stone, Allison   +5 more
core   +3 more sources

Non-mammalian model organisms in epigenetic research : an overview [PDF]

, 2020
Recent advances in sequencing technology and genome editing tools had an indisputably enormous impact on our understanding of complex biological pathways and their genetic and epigenetic regulation.
Baruah, Sri Kartik, Bossier, Peter, Norouzitallab, Parisa, Vanrompay, Daisy   +3 more
core   +2 more sources

Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species

Advanced Science, EarlyView.
This study identifies ferroptosis as a key driver of cellular senescence, with its inhibition delaying aging and extending healthspan across species. During senescence, ferroptosis worsens, increasing oxidative stress and lipid peroxidation, which accelerate aging.
Hai‐Jun Fu, Xing‐Yue Zhou, Da‐Lian Qin, Qan Qiao, Qiao‐Zhi Wang, Shi‐Ying Li, Yun‐Fei Zhu, Ya‐Ping Li, Jiang‐Min Zhou, Hui Cai, Fei‐Hong Huang, Lu Yu, Long Wang, An‐Guo Wu, Jian‐Ming Wu, Xiao‐Gang Zhou   +15 more
wiley   +1 more source

Lipidomic Analysis of Caenorhabditis elegans Embryos

Bio-Protocol, 2017
Metabolomic is an emerging field of system biology. Lipidomic, a branch of metabolomic, aims to characterize lipophilic metabolites in biological systems. Caenorhabditis elegans (C. elegans) is a genetically tractable and versatile animal model for novel
Hung-Chi Yang, Cheng-Yu Hung, Yi-Yun Pan, Szecheng Lo, Daniel Chiu   +4 more
doaj   +1 more source

Differences in collagen prolyl 4-hydroxylase assembly between two Caenorhabditis nematode species despite high amino acid sequence identity of the enzyme subunits [PDF]

, 2007
The collagen prolyl 4-hydroxylases (P4Hs) are essential for proper extracellular matrix formation in multicellular organisms. The vertebrate enzymes are α2β2 tetramers, in which the β subunits are identical to protein disulfide ...
Abrams, Alan D. Winter, Annunen, Annunen, Annunen, Antony P. Page, Bessereau, Crossen, D'Andrea, Friedman, Gillian McCormack, Helaakoski, Hieta, Hill, Johanna Myllyharju, John, Katriina Keskiaho, Kivirikko, Kivirikko, Kukkola, Lamberg, Liisa Kukkola, Marie-Anne Felix, Merriweather, Myllyharju, Myllyharju, Myllyharju, Myllyharju, Myllyharju, Myllyharju, Nissi, Page, Pekkala, Quevillon, Riihimaa, Stein, Sulston, Thein, Van den Diepstraten, Veijola, Veijola, Vuori, Williams, Winter, Winter   +44 more
core   +1 more source

Two New Cases Expand the Phenotypic Spectrum of TUBG1 Missense Variants

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The gamma‐tubulin ring complex (γ‐TuRC) plays a role in coordinating centrosome and spindle pole body formation during cell division. TUBG1 encodes a critical component of the γ‐TuRC. Pathogenic TUBG1 variants can cause a range of alterations in cortical gyral patterning, microcephaly, and other neurological manifestations.
Roser Urreizti, Jessica Vissicchio, Mohamed Idries, Monica Cozar, Raquel Rabionet, Tyhiesia Donald, Elizabeth J. Bhoj, Tomoki T. Nomakuchi, Shannon C. Shipley, Andrew E. Timms, Ghayda M. Mirzaa, Mercedes Serrano, Andrew K. Sobering   +12 more
wiley   +1 more source

First person – Éva Saskői

Disease Models & Mechanisms, 2020
First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Éva Saskői is first author on ‘The SDHB Arg230His
doaj   +1 more source

Cysteine synthases CYSL-1 and CYSL-2 mediate C. elegans heritable adaptation to P. vranovensis infection

Nature Communications, 2020
Caenorhabditis elegans exhibits multigenerational adaptation to bacterial infection but the mechanisms remain unclear. Here, the authors show that C.
Nicholas O. Burton, Cristian Riccio, Alexandra Dallaire, Jonathan Price, Benjamin Jenkins, Albert Koulman, Eric A. Miska   +6 more
doaj   +1 more source

The nutritional requirements of Caenorhabditis elegans

Genes & Nutrition, 2019
Animals require sufficient intake of a variety of nutrients to support their development, somatic maintenance and reproduction. An adequate diet provides cell building blocks, chemical energy to drive cellular processes and essential nutrients that ...
Aleksandra Zečić, Ineke Dhondt, B. Braeckman   +2 more
semanticscholar   +1 more source