Results 91 to 100 of about 132,111 (275)

Global Proteomic Response of Caenorhabditis elegans Against PemKSa Toxin

Frontiers in Cellular and Infection Microbiology, 2019
Bacterial exotoxins are major causative agents that infect by promoting cell and tissue damages through disabling the invading host immune system. However, the mode of action by which toxins modulate host immune system and lead cell death is still not ...
Dilawar Ahmad Mir, Krishnaswamy Balamurugan   +1 more
doaj   +1 more source

Tv-RIO1 – an atypical protein kinase from the parasitic nematode Trichostrongylus vitrinus [PDF]

, 2008
Background: Protein kinases are key enzymes that regulate a wide range of cellular processes, including cell-cycle progression, transcription, DNA replication and metabolic functions. These enzymes catalyse the transfer of phosphates to serine, threonine
Gasser, Robin B., Hu, Min, LaRonde-LeBlanc, Nicole, Sternberg, Paul W.   +3 more
core   +6 more sources

Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network [PDF]

Nature Methods, 2008
To provide accurate biological hypotheses and elucidate global properties of cellular networks, systematic identification of protein-protein interactions must meet high quality standards.We present an expanded C. elegans protein-protein interaction network, or 'interactome' map, derived from testing a matrix of approximately 10,000 x approximately 10 ...
Simonis, Nicolas, Rual, Jean-François, Carvunis, Anne-Ruxandra, Tasan, Murat, Lemmens, Irma, Hirozane-Kishikawa, Tomoko, Hao, Tong, Sahalie, Julie M, Venkatesan, Kavitha, Gebreab, Fana, Cevik, Sebiha, Klitgord, Niels, Fan, Changyu, Braun, Pascal, Li, Ning, Ayivi-Guedehoussou, Nono, Dann, Elizabeth, Bertin, Nicolas, Szeto, David, Dricot, Amélie, Yildirim, Muhammed A, Lin, Chenwei, de Smet, Anne-Sophie, Kao, Huey-Ling, Simon, Christophe, Smolyar, Alex, Ahn, Jin Sook, Tewari, Muneesh, Boxem, Mike, Milstein, Stuart, Yu, Haiyuan, Dreze, Matija, Vandenhaute, Jean, Gunsalus, Kristin C, Cusick, Michael E, Hill, David E, Tavernier, Jan, Roth, Frederick P, Vidal, Marc   +38 more
openaire   +3 more sources

Cell Cycle‐Specific Regulation of Centrosome Clustering Dynamics in Cancer Cells by the Multifunctional Kinesin HSET

Advanced Science, EarlyView.
CDK5RAP2 associates with the kinesin HSET and forms co‐condensates. HSET motors drive the directional transport of CDK5RAP2 condensates toward microtubule minus ends. During mitosis, HSET self‐assembly further stabilizes clustered centrosomes, thereby enabling pseudo‐bipolar spindle formation in cancer cells with supernumerary centrosomes. Upon mitotic
Po‐Pang Chen, Athira Saju, Chia‐Chou Wu, Tzu‐Han Weng, Su‐Yi Tsai, Tzu‐Lun Huang, Jia‐Ying Su, Chien‐Ling Lin, Yu‐Chun Lin, See‐Yeun Ting, Sheng‐hong Chen, Kuo‐Chiang Hsia   +11 more
wiley   +1 more source

RNAi effector diversity in nematodes.

PLoS Neglected Tropical Diseases, 2011
While RNA interference (RNAi) has been deployed to facilitate gene function studies in diverse helminths, parasitic nematodes appear variably susceptible.
Johnathan J Dalzell, Paul McVeigh, Neil D Warnock, Makedonka Mitreva, David McK Bird, Pierre Abad, Colin C Fleming, Tim A Day, Angela Mousley, Nikki J Marks, Aaron G Maule   +10 more
doaj   +1 more source

A Protein Disulfide Isomerase Controls Neuronal Migration through Regulation of Wnt Secretion

Cell Reports, 2019
Summary: Appropriate Wnt morphogen secretion is required to control animal development and homeostasis. Although correct Wnt globular structure is essential for secretion, proteins that directly mediate Wnt folding and maturation remain uncharacterized ...
Nanna Torpe, Sandeep Gopal, Oguzhan Baltaci, Lorenzo Rella, Ava Handley, Hendrik C. Korswagen, Roger Pocock   +6 more
doaj   +1 more source

Antiviral RNA Interference against Orsay Virus Is neither Systemic nor Transgenerational in Caenorhabditis elegans. [PDF]

, 2015
UNLABELLED: Antiviral RNA-mediated silencing (RNA interference [RNAi]) acts as a powerful innate immunity defense in plants, invertebrates, and mammals. In Caenorhabditis elegans, RNAi is systemic; i.e., RNAi silencing signals can move between cells and ...
Ashe, Alyson, Le Pen, J?r?mie, Miska, Eric A., Sarkies, Peter, Tanguy, M?lanie   +4 more
core   +5 more sources

Deep Learning‐Assisted Coherent Raman Scattering Microscopy

Advanced Intelligent Discovery, EarlyView.
The analytical capabilities of coherent Raman scattering microscopy are augmented through deep learning integration. This synergistic paradigm improves fundamental performance via denoising, deconvolution, and hyperspectral unmixing. Concurrently, it enhances downstream image analysis including subcellular localization, virtual staining, and clinical ...
Jianlin Liu, Rujia Liu, Xinyan Zhang, Xun Chen, Shuhua Yue   +4 more
wiley   +1 more source

A novel function for the Caenorhabditis elegans torsin OOC-5 in nucleoporin localization and nuclear import. [PDF]

, 2015
Torsin proteins are AAA+ ATPases that localize to the endoplasmic reticular/nuclear envelope (ER/NE) lumen. A mutation that markedly impairs torsinA function causes the CNS disorder DYT1 dystonia. Abnormalities of NE membranes have been linked to torsinA
Dauer, William T, Hall, David H, Nguyen, Ken CQ, Rose, Lesilee S, VanGompel, Michael JW   +4 more
core   +2 more sources

Prion protein inCaenorhabditis elegans [PDF]

Prion, 2011
The infectious agent of prion diseases is believed to be nucleic acid-free particles composed of misfolded conformational isomers of a host protein known as prion protein (PrP). Although this "protein-only" concept is generally accepted, decades of extensive research have not been able to elucidate the mechanisms by which PrP misfolding leads to ...
Kyung-Won, Park, Liming, Li
openaire   +2 more sources