Results 91 to 100 of about 73,600 (228)

Kinesins in Caenorhabditis elegans neuronal morphogenesis

Open Biology
Neuronal morphogenesis is regulated by intracellular transport and cytoskeletal dynamics. Kinesin superfamily proteins (KIFs), or kinesins, function as molecular motors for intracellular transport and as regulators of the microtubule cytoskeleton, making
Shinsuke Niwa, Kyoko Chiba
doaj   +1 more source

Parental Exposure to Nanoplastics and Graphene Oxide Induces Transgenerational Toxicity in Caenorhabditis elegans

Journal of Applied Toxicology, EarlyView.
ABSTRACT Environmental pollution by emerging contaminants such as nanoplastics (NPs) and graphene oxide (GO) represents a growing threat to global health and ecosystems. This study investigated the effects of parental exposure, both isolated and combined, to 100 μg/L NPs (polystyrene, spherical, 100 nm) and 100 mg/L GO, using Caenorhabditis elegans as ...
Gabriela Corrêa Soares, Larissa Müller, Suamy Machado Cruz, Andy Taipe Huisa, Danilo Roberto Carvalho Ferreira, Clascídia Aparecida Furtado, Juliane Ventura‐Lima   +6 more
wiley   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

ACE‐inhibitory peptide Leu‐Tyr‐Ala in skeletal muscle actin exhibits anti‐aging effects through the inhibition of acn‐1 in Caenorhabditis elegans

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Inhibitors of angiotensin‐converting enzyme (ACE) are used in pharmaceuticals and functional foods. Captopril, a well‐known ACE inhibitor, extends the lifespan of the nematode Caenorhabditis elegans. Bioactive peptides derived from food sources are considered safe ACE inhibitors.
Issei Yokoyama, Minori Yamane, Kanaho Watanabe, Abdul Fatah, Yusuke Komiya, Jun Nagasao, Keizo Arihara   +6 more
wiley   +1 more source

Identification of proteotoxic and proteoprotective bacteria that non-specifically affect proteins associated with neurodegenerative diseases

iScience
Summary: There are no cures for neurodegenerative protein conformational diseases (PCDs), such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD).
Alyssa C. Walker, Rohan Bhargava, Michael J. Bucher, Yoan M. Argote, Amanda S. Brust, Daniel M. Czyż   +5 more
doaj   +1 more source

Presynaptic Congenital Myasthenic Syndromes

Muscle &Nerve, EarlyView.
ABSTRACT Presynaptic congenital myasthenic syndromes (CMS) encompass a large number of rare neurologic disorders caused by impaired release of acetylcholine (ACh) from motor nerve terminals. There are two main groups of presynaptic CMS: one in which the amount of ACh in synaptic vesicles (SV) is diminished and another in which the mechanism of synaptic
Ricardo A. Maselli
wiley   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Toxicity of Four Common Environmental Chemicals Across Caenorhabditis elegans Life Stages Supporting the One Health Concept

Environmental Toxicology, EarlyView.
ABSTRACT Pesticides and pharmaceuticals are among the most common chemical groups in waterbodies and soils, and their universal distribution raises concerns about potential adverse effects on nontarget organisms and humans. Reproductive output disruption is of particular concern, as it transposes effects from the individual to the next generations at ...
Fábio Campos, Maria D. Pavlaki, Amadeu M. V. M. Soares, Susana Loureiro   +3 more
wiley   +1 more source

Nanomaterials' Multigenerational Effects by Single and Joint Exposure in Non‐mammalian Models

Environmental Toxicology, EarlyView.
ABSTRACT Nanotoxicology has mainly focused on single‐generation studies, leaving multigenerational toxicity underexplored. Having animal welfare recently gained importance, we aimed to provide the state‐of‐the‐art of knowledge about multigenerational effects in non‐mammalian models in the case of nanomaterials (NM) single and joint exposure to other ...
Andy Joel Taipe Huisa, Analía Ale, Azael Francisco Silva Neto, Lorena De Mendonça Lucena, Marcelo Estrella Josende, Milena Ferreira de Lima, Rhayanny Kethylly Pereira Santos, Martín Federico Desimone, Priscila Gubert, José María Monserrat   +9 more
wiley   +1 more source