Altered Function of the DnaJ Family Cochaperone DNJ-17 Modulates Locomotor Circuit Activity in a Caenorhabditis elegans Seizure Model [PDF]
G3: Genes, Genomes, Genetics, 2016 The highly conserved cochaperone DnaJ/Hsp40 family proteins are known to interact with molecular chaperone Hsp70, and can regulate many cellular processes including protein folding, translocation, and degradation.
Seika Takayanagi-Kiya, Yishi Jin
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CemOrange2 fusions facilitate multifluorophore subcellular imaging in C. elegans. [PDF]
PLoS ONE, 2019 Due to its ease of genetic manipulation and transparency, Caenorhabditis elegans (C. elegans) has become a preferred model system to study gene function by microscopy.
Brian J Thomas +14 more
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Nuclear/Cytoplasmic Fractionation of Proteins from Caenorhabditis elegans [PDF]
Bio-Protocol, 2018 C. elegans is widely used to investigate biological processes related to health and disease. To study protein localization, fluorescently-tagged proteins can be used in vivo or immunohistochemistry can be performed in whole worms.
Alejandro Mata-Cabana +3 more
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Auxin-mediated Protein Degradation in Caenorhabditis elegans
Bio-Protocol, 2020 The auxin-inducible degron (AID) technology was recently adapted for use in the nematode Caenorhabditis elegans. Rapid degradation of C. elegans proteins tagged with an AID is mediated by a plant-specific F-box protein, transport inhibitor response 1 ...
Michael Martinez, David Matus
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Recent progress in regulation of aging by non-coding RNAs in Caenorhabditis elegans [PDF]
Animal Cells and SystemsNon-coding RNAs (ncRNAs) are RNA molecules that are not translated into proteins. Recent advances in RNA biology have uncovered roles of ncRNAs in physiological processes, including aging.
Seungjae Hwang +2 more
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Kinesins in Caenorhabditis elegans neuronal morphogenesis [PDF]
Open BiologyNeuronal morphogenesis is regulated by intracellular transport and cytoskeletal dynamics. Kinesin superfamily proteins (KIFs), or kinesins, function as molecular motors for intracellular transport and as regulators of the microtubule cytoskeleton, making
Shinsuke Niwa, Kyoko Chiba
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Prereplication complex proteins get caught moonlighting
PLoS Biology, 2022 In this issue of PLOS Biology, Lattmann and colleagues report a new function for proteins of the DNA prereplication complex promoting the anchor cell to invade through the basement membrane and initiate vulval development in Caenorhabditis elegans.
Hilary A. Coller
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Identification and Functional Analysis of Cytokine-Like Protein CLEC-47 in Caenorhabditis elegans
mBio, 2021 A variety of effector proteins contribute to host defense in the nematode Caenorhabditis ...
Wen Pan +4 more
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G3: Genes, Genomes, Genetics, 2021 The visualization of biological processes using fluorescent proteins and dyes in living organisms has enabled numerous scientific discoveries.
Cori K Cahoon, Diana E Libuda
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Genetic analysis suggests a surface of PAT-4 (ILK) that interacts with UNC-112 (kindlin)
G3: Genes, Genomes, Genetics, 2022 Integrin plays a crucial role in the attachment of cells to the extracellular matrix. Integrin recruits many proteins intracellularly, including a 4-protein complex (kindlin, ILK, PINCH, and parvin).
Hiroshi Qadota +6 more
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