Results 41 to 50 of about 73,600 (228)

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

An SRR1 domain-containing protein is required for efficient Orsay virus replication in Caenorhabditis elegans

Journal of Virology
Viruses depend on their hosts for completing their life cycle, and a better understanding of virus replication can inform therapeutic strategies. Using the Orsay virus-Caenorhabditis elegans experimental platform, we identified by a forward genetic ...
Chika Fujii, David Wang
doaj   +1 more source

NFYB Integrates Hormonal Signals into Tissue Allometry by Promoting Protein Biosynthesis

Advanced Science, EarlyView.
In the American cockroach, NFYB acts as a spatiotemporin that translates distinct hormonal cues into tissue‐specific allometry. Juvenile hormone activates NFYB in the early fat body, while 20‐hydroxyecdysone induces it in late wing pads. NFYB then promotes protein biosynthesis via core translational machinery, driving differential growth across the ...
Fangfang Liu, Shiming Zhu, Sishi Xia, Xiaoshuai Zhang, Qin Li, Zhanquan Zeng, Yuqing Liu, Wanyin Liang, Guanyu Zhou, Erxia Du, Suning Liu, Sheng Li   +11 more
wiley   +1 more source

Altered Function of the DnaJ Family Cochaperone DNJ-17 Modulates Locomotor Circuit Activity in a Caenorhabditis elegans Seizure Model

G3: Genes, Genomes, Genetics, 2016
The highly conserved cochaperone DnaJ/Hsp40 family proteins are known to interact with molecular chaperone Hsp70, and can regulate many cellular processes including protein folding, translocation, and degradation.
Seika Takayanagi-Kiya, Yishi Jin
doaj   +1 more source

Investigating the Role of RIO Protein Kinases in Caenorhabditis elegans

PLOS ONE, 2015
RIO protein kinases (RIOKs) are a relatively conserved family of enzymes implicated in cell cycle control and ribosomal RNA processing. Despite their functional importance, they remain a poorly understood group of kinases in multicellular organisms. Here, we show that the C.
Mendes, Tasha K, Novakovic, Stevan, Raymant, Greta, Bertram, Sonja E, Esmaillie, Reza, Nadarajan, Saravanapriah, Breugelmans, Bert, Hofmann, Andreas, Gasser, Robin B, Colaiacovo, Monica P, Boag, Peter R   +10 more
openaire   +6 more sources

An Edible Biohybrid Platform Accomplishes In Situ Fenton‐Mediated Enteral Nanoplastics Aging and Excretion

Advanced Science, EarlyView.
An edible biohybrid platform triggers nanoplastics (NPs) aging and agglomeration by in situ generating hydroxyl radicals within the intestine. The enlarged NPs are unable to penetrate the intestine and are subsequently excreted. Simultaneously, probiotic biofilms reinforce the intestinal barrier.
Su Zhou, Anran Yan, Haowei Guo, Ping Chen, Qiang Chu   +4 more
wiley   +1 more source

Yolk-deprived Caenorhabditis elegans secure brood size at the expense of competitive fitness

Life Science Alliance, 2023
Many egg-laying species lower fecundity when yolk is in short supply, but not C. elegans . They still produce abundant offspring, yet of decreased quality. Oviparous animals support reproduction via the incorporation of yolk as a nutrient source into the
Ellen Geens, Pieter Van de Walle, Francesca Caroti, Rob Jelier, Christian Steuwe, Liliane Schoofs, Liesbet Temmerman   +6 more
doaj   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

Copper Homeostasis in the Model Organism C. elegans

Cells
Cellular and organismic copper (Cu) homeostasis is regulated by Cu transporters and Cu chaperones to ensure the controlled uptake, distribution and export of Cu ions.
Verena Alexia Ohse, Lars-Oliver Klotz, Josephine Priebs   +2 more
doaj   +1 more source

The role of RNA-binding proteins in orchestrating germline development in Caenorhabditis elegans

Frontiers in Cell and Developmental Biology, 2023
RNA passed from parents to progeny controls several aspects of early development. The germline of the free-living nematode Caenorhabditis elegans contains many families of evolutionarily conserved RNA-binding proteins (RBPs) that target the untranslated ...
Mennatallah M. Y. Albarqi, Sean P. Ryder
doaj   +1 more source