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Delaying aging in Caenorhabditis elegans with protein aggregation inhibitors
Biochemical and Biophysical Research Communications, 2017Recent evidence suggests that during aging there is widespread accumulation of aggregated insoluble proteins, even in the absence of pathological conditions. Pharmacological manipulation of protein aggregation might be helpful to unveil the involvement of protein aggregates during aging, as well as to develop novel strategies to delay aging.
Karina Cuanalo-Contreras +4 more
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Tissue-specific synthesis of yolk proteins in Caenorhabditis elegans
Developmental Biology, 1983The primary site of yolk protein synthesis in the nematode, Caenorhabditis elegans, has been determined. In animals containing no gonadal cells (obtained by laser ablation of the gonadal precursor cells early in development), yolk proteins are present in abundance. This demonstrates that yolk proteins are made outside the gonad.
J, Kimble, W J, Sharrock
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Identification of Protein Substrates for Transglutaminase in Caenorhabditis elegans
Biochemical and Biophysical Research Communications, 2001Transglutaminase-dependent cross-linking of proteins leads to protein polymerisation that confers stability as well as resistance to mechanical disruption and chemical attack. Various transglutaminases have been implicated in a wide range of biological phenomena occurring in both extracellular and intracellular compartments, but further clarification ...
A, Mádi +4 more
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Patterns of proteins synthesized during development of Caenorhabditis elegans
Developmental Biology, 1979Abstract Two-dimensional gel electrophoresis has been used to analyze proteins synthesized during postembryonic development of the nematode Caenorhabditis elegans . This organism is favorable for these studies because it has a limited number of cells, it is genetically well-defined, and its development is currently under investigation in several ...
K, Johnson, D, Hirsh
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Protein oxidation during aging of the nematode Caenorhabditis elegans
Free Radical Biology and Medicine, 2002The nematode Caenorhabditis elegans has proven a robust genetic model for studies of aging, including the roles of oxidative stress and protein damage. In this review, we focus on the genetics of select long-lived (e.g., age-1, daf-2, daf-16) and short-lived (e.g., mev-1) mutants that have proven useful in revealing the relationships that exist among ...
Naoaki, Ishii +2 more
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Immunoglobulin superfamily proteins in Caenorhabditis elegans.
Journal of molecular biology, 2000The predicted proteins of the genome of Caenorhabditis elegans were analysed by various sequence comparison methods to identify the repertoire of proteins that are members of the immunoglobulin superfamily (IgSF). The IgSF is one of the largest families of protein domain in this genome and likely to be one of the major families in other multicellular ...
S A, Teichmann, C, Chothia
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5′-AMP-Activated Protein Kinase Signaling in Caenorhabditis elegans
2016AMP-activated protein kinase (AMPK) is one of the central regulators of cellular and organismal metabolism in eukaryotes. Once activated by decreased energy levels, it induces ATP production by promoting catabolic pathways while conserving ATP by inhibiting anabolic pathways.
Moloud, Ahmadi, Richard, Roy
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Cadherin superfamily proteins in Caenorhabditis elegans and Drosophila melanogaster
Journal of Molecular Biology, 2001The ability to form selective cell-cell adhesions is an essential property of metazoan cells. Members of the cadherin superfamily are important regulators of this process in both vertebrates and invertebrates. With the advent of genome sequencing projects, determination of the full repertoire of cadherins available to an organism is possible and here ...
E, Hill +3 more
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Monitoring Protein Synthesis in Caenorhabditis elegans Using SILAC
2017The static levels of proteins are the net results of their production and clearance regulated by the activities of proteins involved in their synthesis, degradation, and transportation. Therefore, the information on the rates of protein synthesis and clearance is needed to understand the underlying dynamic nature of a proteome.
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Characterization of the Caenorhabditis elegans G protein-coupled serotonin receptors
Invertebrate Neuroscience, 2006Serotonin (5-HT) regulates a wide range of behaviors in Caenorhabditis elegans, including egg laying, male mating, locomotion and pharyngeal pumping. So far, four serotonin receptors have been described in the nematode C. elegans, three of which are G protein-coupled receptors (GPCR), (SER-1, SER-4 and SER-7), and one is an ion channel (MOD-1).
Carre-Pierrat, Maïté +6 more
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