Modelling the Establishment of PAR Protein Polarity in the One-Cell C. elegans Embryo [PDF]
, 2008 At the one-cell stage, the C. elegans embryo becomes polarized along the anterior-posterior axis. The PAR proteins form complementary anterior and posterior domains in a dynamic process driven by cytoskeletal rearrangement.
Aceto +36 more
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The astacin metalloprotease moulting enzyme NAS-36 is required for normal cuticle ecdysis in free-living and parasitic nematodes [PDF]
, 2011 Nematodes represent one of the most abundant and species-rich groups of animals on the planet, with parasitic species causing chronic, debilitating infections in both livestock and humans worldwide. The prevalence and success of the nematodes is a direct
ANDREW J. BIRNIE +5 more
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G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans. [PDF]
, 2017 G protein-coupled receptors (GPCRs) regulate many animal behaviors. GPCR signaling is mediated by agonist-promoted interactions of GPCRs with heterotrimeric G proteins, GPCR kinases (GRKs), and arrestins.
Aryal, Dipendra K. +5 more
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A novel function for the Caenorhabditis elegans torsin OOC-5 in nucleoporin localization and nuclear import. [PDF]
, 2015 Torsin proteins are AAA+ ATPases that localize to the endoplasmic reticular/nuclear envelope (ER/NE) lumen. A mutation that markedly impairs torsinA function causes the CNS disorder DYT1 dystonia. Abnormalities of NE membranes have been linked to torsinA
Dauer, William T +4 more
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Distinct roles of transcription factors EGL-46 and DAF-19 in specifying the functionality of a polycystin-expressing sensory neuron necessary for C. elegans male vulva location behavior [PDF]
, 2003 Caenorhabditis elegans polycystins LOV-1 and PKD-2 are expressed in the male-specific HOB neuron, and are necessary for sensation of the hermaphrodite vulva during mating. We demonstrate that male vulva location behavior and expression of lov-1 and pkd-2
Bürglin, Thomas R. +3 more
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A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes [PDF]
, 2014 Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological ...
Carlow, Clotilde K. S. +7 more
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Microtubule-dependent ribosome localization in C. elegans neurons. [PDF]
, 2017 Subcellular localization of ribosomes defines the location and capacity for protein synthesis. Methods for in vivo visualizing ribosomes in multicellular organisms are desirable in mechanistic investigations of the cell biology of ribosome dynamics. Here,
Ellisman, Mark H +3 more
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Genetic and cellular sensitivity of Caenorhabditis elegans to the chemotherapeutic agent cisplatin [PDF]
, 2018 Cisplatin and derivatives are commonly used as chemotherapeutic agents. Although the cytotoxic action of cisplatin on cancer cells is very efficient, clinical oncologists need to deal with two major difficulties, namely the onset of resistance to the ...
Boxem, Mike +12 more
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Investigating hookworm genomes by comparative analysis of two Ancylostoma species [PDF]
, 2005 Background Hookworms, infecting over one billion people, are the mostly closely related major human parasites to the model nematode Caenorhabditis elegans.
Arasu, P. +12 more
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Unexpected cell type-dependent effects of autophagy on polyglutamine aggregation revealed by natural genetic variation in C. elegans. [PDF]
, 2020 BACKGROUND: Monogenic protein aggregation diseases, in addition to cell selectivity, exhibit clinical variation in the age of onset and progression, driven in part by inter-individual genetic variation. While natural genetic variants may pinpoint plastic
Alexander-Floyd, J +6 more
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