Altered Function of the DnaJ Family Cochaperone DNJ-17 Modulates Locomotor Circuit Activity in a Caenorhabditis elegans Seizure Model [PDF]
G3: Genes, Genomes, Genetics, 2016 The highly conserved cochaperone DnaJ/Hsp40 family proteins are known to interact with molecular chaperone Hsp70, and can regulate many cellular processes including protein folding, translocation, and degradation.
Seika Takayanagi-Kiya, Yishi Jin
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CemOrange2 fusions facilitate multifluorophore subcellular imaging in C. elegans. [PDF]
PLoS ONE, 2019 Due to its ease of genetic manipulation and transparency, Caenorhabditis elegans (C. elegans) has become a preferred model system to study gene function by microscopy.
Brian J Thomas +14 more
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Immunoprecipitation of Proteins in Caenorhabditis elegans
Bio-Protocol, 2015 Immunoprecipitation (IP) is a biochemical technique to precipitate a protein out of solution using an antigen that can specifically bind to that protein.
Kevin Chan +3 more
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Identification and Functional Analysis of Cytokine-Like Protein CLEC-47 in Caenorhabditis elegans
mBio, 2021 A variety of effector proteins contribute to host defense in the nematode Caenorhabditis ...
Wen Pan +4 more
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Comparative functional analysis of the Caenorhabditis elegans and Drosophila melanogaster proteomes. [PDF]
PLoS Biology, 2009 The nematode Caenorhabditis elegans is a popular model system in genetics, not least because a majority of human disease genes are conserved in C. elegans.
Sabine P Schrimpf +12 more
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Nuclear/Cytoplasmic Fractionation of Proteins from Caenorhabditis elegans [PDF]
Bio-Protocol, 2018 C. elegans is widely used to investigate biological processes related to health and disease. To study protein localization, fluorescently-tagged proteins can be used in vivo or immunohistochemistry can be performed in whole worms.
Alejandro Mata-Cabana +3 more
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The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones. [PDF]
PLoS Genetics, 2016 Protein AMPylation by Fic domain-containing proteins (Fic proteins) is an ancient and conserved post-translational modification of mostly unexplored significance. Here we characterize the Caenorhabditis elegans Fic protein FIC-1 in vitro and in vivo. FIC-
Matthias C Truttmann +5 more
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Proteome-based investigation of O-GlcNAcylation in a C. elegans model of ageing and Alzheimer's disease: Functional support for earlier hypothesis-generating findings. [PDF]
PLoS ONEO-linked N-acetylglucosamine (O-GlcNAc) is a post-translational modification of serine and threonine residues on nuclear and cytoplasmic proteins. The identity of O-GlcNAcylated proteins during ageing and neurodegenerative disease remains incompletely ...
Fernando Garcia Olivera
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Recent progress in regulation of aging by non-coding RNAs in Caenorhabditis elegans [PDF]
Animal Cells and SystemsNon-coding RNAs (ncRNAs) are RNA molecules that are not translated into proteins. Recent advances in RNA biology have uncovered roles of ncRNAs in physiological processes, including aging.
Seungjae Hwang +2 more
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Prereplication complex proteins get caught moonlighting
PLoS Biology, 2022 In this issue of PLOS Biology, Lattmann and colleagues report a new function for proteins of the DNA prereplication complex promoting the anchor cell to invade through the basement membrane and initiate vulval development in Caenorhabditis elegans.
Hilary A. Coller
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