Results 171 to 180 of about 4,758 (202)

Cryoablation plus sintilimab and lenvatinib in advanced or metastatic intrahepatic cholangiocarcinoma: a phase 2 trial. [PDF]

Nat Cancer
Gu S, Luo Q, Zhang Y, Qian L, Chen K, Liang F, Hu Y, Zhou R, Wang Y, Liu J, Ning Z, Xu L, Meng Z, Li Y, Wang P.   +14 more
europepmc   +1 more source

Long noncoding RNA <i>DREAMer</i> bridges the DREAM complex and E2f1 to regulate endoreplication in <i>Drosophila</i>. [PDF]

Sci Adv
Li D, Jin T, Liu J, Lu C, Yang X, Zhang H, Bi L, Yan Y, Zhang L, Sang Y, Jin B, Bi X.   +11 more
europepmc   +1 more source

ZEB1, a novel regulator of Junctional Adhesion Molecule A, impacts sensitivity of pancreatic cancer-associated fibroblasts to oncolytic reovirus

Dam N, Harryvan TJ, Dang H, Ioannidis G, Schmierer B, Hawinkels LJ, Kemp V.   +6 more
europepmc   +1 more source

Anti-activin treatment increases T cell infiltration in breast and pancreatic tumours and promotes survival in a SMAD4-null mouse pancreatic cancer model

McCluney S, Park D, Miller DS, Mehić M, Bloxham RD, De Vries E, Wang X, Boeing S, D’Antonio L, Wieteska Ł, Pyeatt G, Strohbuecker S, Chakravarty P, Maia De Oliveira T, Wilkinson RW, Hyvönen M, Hunt J, Hill CS.   +17 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Current mechanistic insights into biochemical properties and cellular functions of human Caf1 deadenylases.

Cellular Signalling
In eukaryotic cells, mRNA degradation is a critical regulatory step in mRNA metabolism. The removal of poly(A) tail at the 3'-end of mRNA, an initial and rate-limiting step in mRNA degradation termed mRNA deadenylation, is catalyzed by numerous ...
Li-Na Zhang, Jia-Hui Li, Huan-Xi Song, Xiao-Fei Nie   +3 more
semanticscholar   +3 more sources

Mouse CAF1 Can Function As a Processive Deadenylase/3′–5′-Exonuclease in Vitro but in Yeast the Deadenylase Function of CAF1 Is Not Required for mRNA Poly(A) Removal* [PDF]

Journal of Biological Chemistry, 2004
The mouse CAF1 (mCAF1) is an ortholog of the yeast (y) CAF1 protein, which is a component of the CCR4-NOT complex, the major cytoplasmic deadenylase of Saccharomyces cerevisiae. Although CAF1 protein belongs to the DEDDh family of RNases, CCR4 appears to be the principle deadenylase of the CCR4-NOT complex.
Clyde L Denis, Yueh-Chin Chiang, Junji Chen   +2 more
exaly   +3 more sources

The N-terminus modulates human Caf1 activity, structural stability and aggregation

International Journal of Biological Macromolecules, 2012
Caf1 is a deadenylase component of the CCR4-Not complex. Here we found that the removal of the N-terminus resulted in a 30% decrease in human Caf1 (hCaf1) activity, but had no significant influence on main domain structure. The removal of the N-terminus led to a decrease in the thermal stability, while the existence of the N-terminus promoted hCaf1 ...
Yong-Bin Yan, Likui Feng
exaly   +3 more sources

Novel interaction between CCR4 and CAF1 in rice CCR4–NOT deadenylase complex

Plant Molecular Biology, 2016
Rice is an important crop in the world. However, little is known about rice mRNA deadenylation, which is an important regulation step of gene expression at the post-transcriptional level. The CCR4-NOT1 complex contains two key components, CCR4 and CAF1, which are the main cytoplasmic deadenylases in eukaryotic cells.
Wei-Lun Chou, Yue-Lin Chung, Jhen-Cheng Fang, Chung-An Lu   +3 more
semanticscholar   +3 more sources

Conformational states and association mechanism of Yersinia pestis Caf1 subunits

Biochemical and Biophysical Research Communications, 2008
Bacterial infectivity often relies on efficient attachment to the host cells through adhesive extensions. Unveiling the structural basis of the formation of these organelles is of paramount importance for both academic and applicative implications.
Vitagliano Luigi, Ruggiero Alessia, Pedone Carlo, Berisio Rita   +3 more
openaire   +7 more sources

O10 Tuneable Caf1 protein polymers as an innovative and scalable solution for regenerative wound care

British Journal of Dermatology
Wound healing is a complex process essential for tissue restoration, where the extracellular matrix (ECM) plays a crucial role by providing structural and biochemical support to cells.
Yu Nie, H. Waller, D. Peter, Nick J. Reynolds, J. Lakey   +4 more
semanticscholar   +1 more source