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Caffeic Acid, A Versatile Pharmacophore: An Overview

Mini-Reviews in Medicinal Chemistry, 2011
The caffeic acid scaffold, which is abundant in nature, is extremely versatile and is found in a number of biologically active molecules. The purpose of this review is to provide an overview of the pharmacological activity of synthetic caffeic acid analogs including recent reports of anti-inflammatory, anti-cancer, and antiviral activities of these ...
Jérémie A. Doiron   +2 more
openaire   +3 more sources

Chlorogenic acid as an indispensible partner of caffeic acid in coffee via selective regulation of prooxidative actions of caffeic acid

Food Research International, 2023
Chlorogenic acid (CGA) and caffeic acid (CA) are two major phenolic acids in coffee. Though the International Agency for Research on Cancer has classified CA as a Group2B carcinogen, coffee consumption seems generally safe within the usual levels of intake and is more likely to benefit health than to harm it. We thus speculated that CGA may effectively
Xiuli Li   +6 more
openaire   +2 more sources

LC with Electrochemical Detection for Analysis of Caffeic Acid and Caffeic Acid Phenyl Ester in Propolis

Chromatographia, 2011
A simple, sensitive, and accurate liquid chromatographic method with electrochemical detection (ECD) has been developed for analysis of caffeic acid and caffeic acid phenyl ester in propolis. ECD is more sensitive than diode-array detection for analysis of the two phenolic compounds.
Hai-Feng Liu   +5 more
openaire   +2 more sources

Caffeic acid and rosmarinic acid contents in genus Perilla

Journal of Natural Medicines, 2020
Caffeic acid and rosmarinic acid are common components of Labiatae plants, such as shiso (Perilla frutescens Britton var. crispa W. Deane) and Boraginaceae plants. These compounds have various pharmacological activities, such as anti-inflammatory, anti-anxiety, and anti-depressive activities, but the content of these compounds in perilla has not been ...
Yuya Deguchi, Michiho Ito
openaire   +2 more sources

Dietary caffeic acid, ferulic acid and coumaric acid supplements on cholesterol metabolism and antioxidant activity in rats

, 2020
This study was designed to test the lipid-lowering and antioxidative activities of three phenolic compounds, caffeic acid, ferulic acid and coumaric acid. Four groups of rats were given a semisynthetic diet containing 3% of cholesterol for 6 weeks.
Y. Yeh, Ya-Ting Lee, H. Hsieh, D. Hwang
semanticscholar   +1 more source

Reaction of caffeic acid derivatives with acidic nitrite

Tetrahedron Letters, 2001
Abstract Caffeic derivatives were reacted with acidic nitrite at controlled pH in order to mimic the gastric juice conditions. At pH 2, whereas caffeic acid reacts exclusively on the side chain, its esters are readily nitrated. Under more acidic conditions (pH 1), caffeic acid methyl ester undergoes a dimerisation into a norlignan derivative.
Philippe Cotelle, Hervé Vezin
openaire   +2 more sources

Adsorption of caffeic acid on chitosan powder

Polymer Bulletin, 2020
Adsorption of caffeic acid (CA) on chitosan (CH) powder from aqueous solution has been investigated to obtain insoluble CA–CH complex powders having different amount of CA. The pseudo-second kinetic model and the Langmuir, Freundlich and Dubinin–Radushkevich adsorption models were used to describe the kinetic and equilibrium adsorption of CA on CH ...
Ramune Rutkaite   +4 more
openaire   +2 more sources

Caffeic acid alleviates cerebral ischemic injury in rats by resisting ferroptosis via Nrf2 signaling pathway

Acta Pharmacologica Sinica, 2023
Xin-nan Li   +8 more
semanticscholar   +1 more source

Microencapsulation of caffeic acid phenethyl ester and caffeic acid phenethyl amide by inclusion in hydroxypropyl-β-cyclodextrin

Food Chemistry, 2018
Caffeic acid phenethyl ester (CAPE) is a bioactive polyphenolic compound obtained from propolis extract. Although it has a broad therapeutic potential, the bioavailability of CAPE is limited, due to reduced solubility and poor plasmatic stability. Efforts to reduce these pharmacokinetic drawbacks resulted in the synthesis of caffeic acid phenethyl ...
Ana S. Cerqueira   +8 more
openaire   +3 more sources

Cytotoxic activity of caffeic acid and gallic acid against MCF-7 human breast cancer cells: An in silico and in vitro study

Avicenna Journal of Phytomedicine, 2019
Objective: Phenolic compounds have been considered inhibitors of various cancers. Material and Methods: In this study, caffeic acid and gallic acid were appraised for their possible effects on apoptotic genes expression in a breast cancer cell line in ...
Hasan Rezaei-Seresht   +5 more
semanticscholar   +1 more source

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