Results 91 to 100 of about 12,490 (282)

IL-8 as a Potential Therapeutic Target for Periodontitis and Its Inhibition by Caffeic Acid Phenethyl Ester In Vitro

International Journal of Molecular Sciences, 2021
Salivary levels of interleukin-8 (IL-8) are elevated in patients with periodontitis. Caffeic acid phenethyl ester (CAPE) improves the periodontal status in subjects. However, whether CAPE can reduce IL-8 expression is unclear.
Yung-Kai Huang, Kuo-Feng Tseng, P. Tsai, Jie-Sian Wang, Chang-Yu Lee, M. Shen   +5 more
semanticscholar   +1 more source

Fermentation‐Assisted Valorization: A Sustainable Strategy for Turning Fruit By‐Products Into Value‐Added Food Supplements

Food Frontiers, Volume 7, Issue 1, January 2026.
ABSTRACT A substantial proportion of fresh fruit undergoes processing, resulting in underutilized fruit by‑products (FBPs) that are rich in dietary fiber and bioactive compounds. Recent FBP valorization trends demonstrate that fermentation significantly enhances microbiological, nutritional, and sensory attributes, yielding value‑added food supplements.
Abouzar Ghasemi, Salwa Karboune, Denis Groleau, Ismail Fliss   +3 more
wiley   +1 more source

Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites

Scientific Reports, 2017
Caffeic acid phenethyl ester (CAPE), extracted from propolis, was proven to inhibit colon cancer. Caffeic acid p-nitro-phenethyl ester (CAPE-pNO2), a derivative of CAPE, was determined to be an anti-platelet agent and a protector of myocardial ischaemia ...
Hao Tang, Xiaofang Yao, Cong Yao, Xiaoyan Zhao, Hua Zuo, Zhubo Li   +5 more
doaj   +1 more source

Glycosylation Enhances the Physicochemical Properties of Caffeic Acid Phenethyl Ester

Journal of Microbiology and Biotechnology, 2017
In this study, we synthesized a glycosylated derivative of caffeic acid phenethyl ester (CAPE) using the amylosucrase from Deinococcus geothermalis with sucrose as a substrate and examined its solubility, chemical stability, and anti-inflammatory activity.
Keum-Ok, Moon, Soyoon, Park, Myungsoo, Joo, Ki-Tae, Ha, Nam-In, Baek, Cheon-Seok, Park, Jaeho, Cha   +6 more
openaire   +2 more sources

Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy

Food Frontiers, Volume 7, Issue 1, January 2026.
Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli, Anna Maria Posadino, Roberta Giordo, Antonio Barberis, Ylenia Spissu, Redouane Lemoui, William N. Setzer, Javad Sharifi‐Rad, Gianfranco Pintus   +8 more
wiley   +1 more source

Caffeic acid phenethyl ester is protective in experimental ulcerative colitis via reduction in levels of pro-inflammatory mediators and enhancement of epithelial barrier function [PDF]

, 2018
BACKGROUND: Inhibition of the nuclear factor kappa beta (NF-κβ) pathway has been proposed as a therapeutic target due to its key role in the expression of pro-inflammatory genes, including pro-inflammatory cytokines, chemokines, and adhesion molecules ...
Khan, MN, Lane, ME, McCarron, PA, Tambuwala, MM   +3 more
core  

Exploiting members of the BAHD acyltransferase family to synthesize multiple hydroxycinnamate and benzoate conjugates in yeast [PDF]

, 2013
BACKGROUND: BAHD acyltransferases, named after the first four biochemically characterized enzymes of the group, are plant-specific enzymes that catalyze the transfer of coenzyme A-activated donors onto various acceptor molecules. They are responsible for
A Del Olmo, A Eudes, A Eudes, A Eudes, A Eudes, A Moglia, A Reider Apel, A Yamamoto, Aindrila Mukhopadhyay, AV Qualley, Aymerick Eudes, B Jayaprakasam, B Kim, BE Yingyongnarongkul, BG Kim, C Anselmi, C Chen, C Landmann, CB Jendresen, CC Ho, CG Wilkerson, CM Ma, CM Ma, D Hadjipavlou-Litina, D Juminaga, David S. Robinson, DK Kosma, Dominique Loqué, EA Winzeler, Edward E. K. Baidoo, F Jansen, G Bokinsky, G Fodor, G Grynkiewicz, G Murtaza, G Zhao, GD Kim, George Wang, GW Schmidt, H Mo, H Sun, Henrik V. Scheller, HR El-Seedi, IA Kim, J Boatright, J Jiang, J Luo, J Nielsen, J Palazón, J Sheng, J Sun, Jay D. Keasling, JC D’Auria, JC D’Auria, JD Guzman, JD Keasling, Joshua L. Heazlewood, K Burhenne, KK Hong, KO Evans, Lucien Roux, M Kikugawa, M Sullivan, Maxence Mouille, MF Tolba, MN Cha, N Dudareva, P Liu, P Zhang, PV van Summeren-Wesenhagen, R Niggeweg, RA Heins, S Fixon-Owoo, S Ohta, S Singh, Samuel Deutsch, SC Chou, SE Bloch, SK Kim, SM Richardson, TB Adams, TS Ham, Tsan-Yu Chiu, Veronica T. Benites, W Runguphan, Y Kimura, Y Zhuang, Yi-Lin Tsai, Z Li   +88 more
core   +2 more sources

Optimized enzymatic synthesis of caffeic acid phenethyl ester by RSM

New Biotechnology, 2010
In this study, optimization of enzymatic synthesis of caffeic acid phenethyl ester (CAPE), catalyzed by immobilized lipase (Novozym 435) from Candida antarctica was investigated. Novozym 435 was used to catalyze caffeic acid and 2-phenylethanol in an isooctane system.
Hsiao-Ching, Chen, Hen-Yi, Ju, Yawo-Kuo, Twu, Jiann-Hwa, Chen, Chieh-Ming J, Chang, Yung-Chuan, Liu, Cheng, Chang, Chwen-Jen, Shieh   +7 more
openaire   +2 more sources

Probiotic Supplementation With Bifidobacterium longum Subsp. Longum BL21 Improves Glycemic Control and Modulates Gut Microbiota in Type 2 Diabetes: A Randomized Controlled Trial

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Supplementation with BL21 led to a significant reduction in HbA1c levels (p = 0.026) compared with placebo. Non‐significant trends toward reduction were also observed for FBG and insulin resistance. The intervention was well tolerated, with a safety profile comparable to placebo.
Chengsheng Zhu, Yinhua Liu, Yanyan Chen, Zhiying Wang, Ya Gao, Fei Xu, Junyi Huang   +6 more
wiley   +1 more source

Cardiovascular Effects of Caffeic Acid and Its Derivatives: A Comprehensive Review

Frontiers in Physiology, 2020
Caffeic acid (CA) and its phenethyl ester (CAPE) are naturally occurring hydroxycinnamic acids with an interesting array of biological activities; e.g., antioxidant, anti-inflammatory, antimicrobial and cytostatic.
Henrique Silva, Henrique Silva, Nuno Miguel F. Lopes   +2 more
doaj   +1 more source