Results 71 to 80 of about 3,475 (164)

The antioxidant property of CAPE depends on TRPV1 channel activation in microvascular endothelial cells

Redox Biology
Caffeic acid phenethyl ester (CAPE) is a hydrophobic phytochemical typically found in propolis that acts as an antioxidant, anti-inflammatory and cardiovascular protector, among several other properties.
Miltha Hidalgo, Bárbara Railef, Vania Rodríguez, Carolina Navarro, Vanessa Rubio, Jorge Meneses-Pacheco, Sandra Soto-Alarcón, Christine Kreindl, Carolina Añazco, Leandro Zuñiga, Omar Porras   +10 more
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Combination of 2 Bioactive Compounds for Treatment of Breast Cancer: Triterpenoid Cucurbitacin I and Phenolic CAPE

Natural Product Communications, 2019
It has been demonstrated that both cucurbitacin I (Cu I) and caffeic acid phenethyl ester (CAPE) have anticancer activities. The current study aimed to examine the proliferation, migration, and colony formation actions of Cu I and CAPE on MCF-7 and MDA ...
Fuat Karakuş, Kadir Yılmaz, Ergül Eyol, Songül Ünüvar   +3 more
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The Immunoregulatory Effects of Caffeic Acid Phenethyl Ester on the Cytokine Secretion of Peripheral Blood Mononuclear Cells From Asthmatic Children

Pediatrics and Neonatology, 2011
Asthma is a chronic inflammatory disease of the airways for which current treatments are mainly based on pharmacological interventions, such as glucocorticoid therapy.
Leticia Bautista Sy, Li-King Yang, Chiau-Juno Chiu, Wen-Mein Wu   +3 more
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Phenolic acid phenethylesters and their corresponding ketones: Inhibition of 5‐lipoxygenase and stability in human blood and HepaRG cells

Pharmacology Research & Perspectives, 2019
5‐lipoxygenase (5‐LO) catalyzes the biosynthesis of leukotrienes, potent lipid mediators involved in inflammatory diseases, and both 5‐LO and the leukotrienes are validated therapeutic targets.
Maroua Mbarik, Samuel J. Poirier, Jérémie Doiron, Ayyoub Selka, David A. Barnett, Marc Cormier, Mohamed Touaibia, Marc E. Surette   +7 more
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Caffeic Acid Phenethyl Ester and Ethanol Extract of Propolis Induce the Complementary Cytotoxic Effect on Triple-Negative Breast Cancer Cell Lines

Molecules, 2015
Chemotherapy of breast cancer could be improved by bioactive natural substances, which may potentially sensitize the carcinoma cells’ susceptibility to drugs. Numerous phytochemicals, including propolis, have been reported to interfere with the viability
Anna Rzepecka-Stojko, Agata Kabała-Dzik, Aleksandra Moździerz, Robert Kubina, Robert D. Wojtyczka, Rafał Stojko, Arkadiusz Dziedzic, Żaneta Jastrzębska-Stojko, Magdalena Jurzak, Ewa Buszman, Jerzy Stojko   +10 more
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New Caffeic Acid Phenylethyl Ester Analogs Bearing Substituted Triazole: Synthesis and Structure-Activity Relationship Study towards 5-Lipoxygenase Inhibition

Journal of Chemistry, 2017
Leukotrienes are biosynthesized by the conversion of arachidonic acid by 5-Lipoxygenase and play a key role in many inflammatory disorders. Inspired by caffeic acid phenylethyl ester (CAPE) (2) and an analog carrying a triazole substituted by cinnamoyl ...
Pierre-Philipe Roy, Diene Faye, Sébastien Blanchard, Marc Cormier, Jérémie A. Doiron, Marc E. Surette, Mohamed Touaibia   +6 more
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Protective role of caffeic acid phenethyl ester against tetramethrine-induced toxicity in mice

Medicine Science, 2016
The purpose of this study was to determine the biochemical, histopathological and genotoxic effects of tetramethrine, which is widely used in domestic and agricultural activities as well as identify the protective effect of caffeic acid phenethyl ester (
Gokhan Nur, Haci Ahmet Deveci, Yusuf Ersan, Oguz Merhan, Mumtaz Nazli, Ozlem Nur   +5 more
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The neuroprotective effects of caffeic acid phenethyl ester against methamphetamine-induced neurotoxicity

Ecotoxicology and Environmental Safety
Methamphetamine (METH) is a highly abused substance on a global scale and has the capacity to elicit toxicity within the central nervous system. The neurotoxicity induced by METH encompasses neuronal degeneration and cellular demise within the substantia
Bin Yang, Xiaohui Tan, Yuzhen Chen, Jing Lin, Jingjie Liang, Xia Yue, Dongfang Qiao, Huijun Wang, Sihao Du   +8 more
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Cardioprotection of CAPE-oNO2 against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro

Redox Biology, 2018
Caffeic acid phenethyl ester (CAPE) could ameliorate myocardial ischemia/reperfusion injury (MIRI) by various mechanisms, but there hadn’t been any reports on that CAPE could regulate silent information regulator 1 (SIRT1) and endothelial nitric oxide ...
Dejuan Li, Xiaoling Wang, Qin Huang, Sai Li, You Zhou, Zhubo Li   +5 more
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Caffeic acid phenethyl ester attenuates neuropathic pain by suppressing the p38/NF-κB signal pathway in microglia

Journal of Pain Research, 2018
Hao Cheng, Yong Zhang, Weiping Lu, Xianzhong Gao, Chenjie Xu, Hongguang Bao Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China Background: Management of neuropathic pain is still a clinical challenge ...
Cheng H, Zhang Y, Lu W, Gao X, Xu C, Bao H   +5 more
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