Results 51 to 60 of about 3,475 (164)

Antimicrobial Effect of Spices and Their Phytochemicals: A Novel Approach to Overcoming Antibiotic Resistance

MedComm, Volume 7, Issue 4, April 2026.
This graphical abstract shows the antibacterial potential of phytochemicals from 15 spices, showcasing key compounds, their extraction methods, and mechanisms of action. It highlights membrane disruption, ROS generation, enzyme inhibition, and biofilm prevention as core antibacterial pathways.
Hettiyahandi Binodh De Silva, Yanqi Dai, Shervanthi Homer‐Vanniasinkam, Mohan Edirisinghe   +3 more
wiley   +1 more source

Water-Mediated Synthesis of (E)-3-(1-Methyl-1H-benzo[d]imidazol-5-yl)-N-phenethylacrylamide, a Caffeic Acid Phenethyl Amide Analogue

Molbank
Caffeic acid phenethyl ester (CAPE) is a phenolic natural product with diverse biological activities, notably anticancer properties. However, its ester group is metabolically unstable.
Muppidi Subbarao, Sean M. Kerwin
doaj   +1 more source

Propolis‐Based Hybrid Nanoflowers as Multifunctional Nanozymes: Structural Integration of Polyphenols for Enhanced Catalytic and Antioxidant Activity

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
ABSTRACT Propolis is a polyphenol‐rich natural resin with well‐documented antioxidant activity; however, its practical application is restricted by poor aqueous solubility and limited stability. Herein, propolis‐based organic–inorganic hybrid nanoflowers (Prp‐Nfs) were synthesized by integrating a propolis extract into a Cu3(PO4)2·3H2O matrix under ...
Cevahir Altinkaynak, Fatih Kirmizikar
wiley   +1 more source

Antiviral Properties of Caffeic Acid Phenethyl Ester and Its Potential Application

Journal of Intercultural Ethnopharmacology, 2015
Caffeic acid phenethyl ester (CAPE) is found in a variety of plants and well-known the active ingredient of the honeybee propolis. CAPE showed anti-inflammatory, anticarcinogenic, antimitogenic, antiviral, and immunomodulatory properties in several studies.
Erdemli, Hacı Kemal, Akyol, Sumeyya, Armutcu, Ferah, Akyol, Omer   +3 more
openaire   +5 more sources

Senomorphic Activity of a Novel Standardized Propolis Extract in Human Dermal Fibroblasts: Molecular Insights Into Clinically Proven Anti‐Wrinkle Efficacy

Journal of Cosmetic Dermatology, Volume 25, Issue 3, March 2026.
ABSTRACT Background We recently demonstrated in a randomized controlled trial (RCT) that a Standardized Propolis Extract (SPE), produced via a patented non‐alcoholic PEG 400/lecithin process, achieves significant clinical anti‐wrinkle efficacy (34% wrinkle depth reduction).
Božo Radić, Jelena Šuran
wiley   +1 more source

Effects of Caffeic Acid Phenethyl Ester on Anastomotic Healing in Secondary Peritonitis

Journal of Investigative Surgery, 2012
We aimed to investigate the effects of caffeic acid phenethyl ester (CAPE) on wound healing in left colonic anastomoses in the presence of intraperitoneal sepsis induced by cecal ligation and puncture (CLP) in a rodent model.This experimental study was conducted on 48 male Wistar albino rats.
Teke, Z., Bostanci, E.B., Yenisey, C., Kelten, Esra Canan, Sacar, S., Simsek, N.G., Düzcan, Süleyman Ender, Akoglu, M.   +7 more
openaire   +6 more sources

Caffeic Acid Phenethyl Ester Regulates PPAR’s Levels in Stem Cells-Derived Adipocytes

PPAR Research, 2016
Hypertrophic obesity inhibits activation of peroxisome proliferators-activated receptor gamma (PPARγ), considered the key mediator of the fully differentiated and insulin sensitive adipocyte phenotype.
Luca Vanella, Daniele Tibullo, Justyna Godos, Francesca Romana Pluchinotta, Claudia Di Giacomo, Valeria Sorrenti, Rosaria Acquaviva, Alessandra Russo, Giovanni Li Volti, Ignazio Barbagallo   +9 more
doaj   +1 more source

Caffeic acid phenethyl ester promotes haematopoietic stem/progenitor cell homing and engraftment

Stem Cell Research & Therapy, 2017
Background Several studies have suggested that caffeic acid phenethyl ester (CAPE) can induce the expression of hypoxia inducible factor-1α (HIF-1α) protein.
Xiaofang Chen, Yi Han, Bowen Zhang, Yiming Liu, Sihan Wang, Tuling Liao, Ziliang Deng, Zeng Fan, Jing Zhang, Lijuan He, Wen Yue, Yanhua Li, Xuetao Pei   +12 more
doaj   +1 more source

Caffeic acid phenethyl ester (CAPE): cornerstone pharmacological studies and drug delivery systems [PDF]

Pharmacia, 2019
Propolis is a natural product with a plethora of biological effects, utilized by traditional medicine since antiquity. However, its application as a pharmaceutical is hindered by its variable composition and difficult standardization. CAPE has been shown
Yordan Yordanov
doaj   +3 more sources

Evaluation of ASC as a therapeutic target for Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract Neuroinflammation is increasingly recognized as a central contributor to the pathogenesis and progression of Alzheimer's disease (AD). The apoptosis‐associated speck‐like protein containing a CARD (ASC), encoded by the PYCARD gene, plays a critical role in the formation of multiple inflammasomes, including NLRP3, a key mediator of inflammation
W. Brent Clayton, Joshua A. Kulas, Jiahui Liu, Nidhi Walia, Claudia Rangel‐Barajas, Travis Johnson, Jie Zhang, Kun Huang, Andrew D. Mesecar, Jeffrey L. Dage, Bruce T. Lamb, Alan D. Palkowitz, Timothy I. Richardson   +12 more
wiley   +1 more source