Metabolic engineering strategies for caffeic acid production in Escherichia coli
Electronic Journal of Biotechnology, 2019 Caffeic acid (CA; 3,4-dihydroxycinnamic acid) is an aromatic compound obtained by the phenylpropanoid pathway. This natural product has antioxidant, antitumor, antiviral, and anti-inflammatory activities.
Georgina Hernández-Chávez +2 more
doaj +1 more source
Caffeic acid phenethyl ester and its amide analogue are potent inhibitors of leukotriene biosynthesis in human polymorphonuclear leukocytes. [PDF]
PLoS ONE, 2012 BACKGROUND: 5-lipoxygenase (5-LO) catalyses the transformation of arachidonic acid (AA) into leukotrienes (LTs), which are important lipid mediators of inflammation.
Luc H Boudreau +6 more
doaj +1 more source
Exploiting members of the BAHD acyltransferase family to synthesize multiple hydroxycinnamate and benzoate conjugates in yeast [PDF]
, 2013 BACKGROUND: BAHD acyltransferases, named after the first four biochemically characterized enzymes of the group, are plant-specific enzymes that catalyze the transfer of coenzyme A-activated donors onto various acceptor molecules. They are responsible for
A Del Olmo +88 more
core +2 more sources
Glycosylation Enhances the Physicochemical Properties of Caffeic Acid Phenethyl Ester
Journal of Microbiology and Biotechnology, 2017 In this study, we synthesized a glycosylated derivative of caffeic acid phenethyl ester (CAPE) using the amylosucrase from Deinococcus geothermalis with sucrose as a substrate and examined its solubility, chemical stability, and anti-inflammatory activity.
Keum-Ok, Moon +6 more
openaire +2 more sources
Contact Dermatitis, Volume 94, Issue 5, Page 494-503, May 2026.Propolis is rarely used in conventional cosmetics within the EU, and such products are therefore unlikely to be significant sources of exposure for patients with positive patch test reactions to propolis. There is no evidence that small amounts of propolis in white beeswax (cera alba) in cosmetics can trigger allergic contact dermatitis in individuals ...
Anton C. de Groot +2 more
wiley +1 more source
Portuguese propolis disturbs glycolytic metabolism of human colorectal cancer in vitro [PDF]
, 2013 Propolis is a resin collected by bees from plant buds and exudates, which is further processed through the activity of bee enzymes. Propolis has been shown to possess many biological and pharmacological properties, such as antimicrobial, antioxidant ...
A Kujumgiev +53 more
core +1 more source
Optimized enzymatic synthesis of caffeic acid phenethyl ester by RSM
New Biotechnology, 2010 In this study, optimization of enzymatic synthesis of caffeic acid phenethyl ester (CAPE), catalyzed by immobilized lipase (Novozym 435) from Candida antarctica was investigated. Novozym 435 was used to catalyze caffeic acid and 2-phenylethanol in an isooctane system.
Hsiao-Ching, Chen +7 more
openaire +2 more sources
Scientific Reports, 2017 Caffeic acid phenethyl ester (CAPE), extracted from propolis, was proven to inhibit colon cancer. Caffeic acid p-nitro-phenethyl ester (CAPE-pNO2), a derivative of CAPE, was determined to be an anti-platelet agent and a protector of myocardial ischaemia ...
Hao Tang +5 more
doaj +1 more source
Morphological changes of apoptosis and cytotoxic effects induced by Caffeic acid phenethyl ester in AGS human gastric cancer cell line [PDF]
, 2014 Introduction: Gastric cancer is the fourth prevalent cancer and the second reason for cancer-associated mortalities worldwide. Caffeic acid phenethyl ester (CAPE) is one of the main medicinal components of propolis.
Amini-Sarteshnizi, Nematallah. +4 more
core
Honey and cancer:current status and future directions [PDF]
, 2016 Cancer is a leading cause of death worldwide and poses a challenge to treatment. With overwhelming evidence of the role played by diet and lifestyle in cancer risk and prevention, there is a growing interest into the search for chemopreventative or ...
Chopra, Mridula +2 more
core +2 more sources