Results 41 to 50 of about 7,555 (199)

Substituted Caffeic and Ferulic Acid Phenethyl Esters: Synthesis, Leukotrienes Biosynthesis Inhibition, and Cytotoxic Activity

Molecules, 2017
Glioblastoma multiforme (GBM) is an aggressive brain tumor that correlates with short patient survival and for which therapeutic options are limited. Polyphenolic compounds, including caffeic acid phenethyl ester (CAPE, 1a), have been investigated for ...
Pier Morin, Patrick-Denis St-Coeur, Jérémie A. Doiron, Marc Cormier, Julie J. Poitras, Marc E. Surette, Mohamed Touaibia   +6 more
doaj   +1 more source

Standardization, anti-carcinogenic potential and biosafety of Indian propolis

Journal of Ayurveda and Integrative Medicine, 2019
Background: Propolis from apiculture is known for wide range of medicinal properties owing to its vast chemical constituents including polyphenols, flavonoids and anticancer agent Caffeic acid phenethyl ester (CAPE).
Harshad Kapare, Sathiyanarayanan Lohidasan, Arulmozhi Sinnathambi, Kakasaheb Mahadik   +3 more
doaj   +1 more source

New Hydroxycinnamic Acid Esters as Novel 5-Lipoxygenase Inhibitors That Affect Leukotriene Biosynthesis

Mediators of Inflammation, 2017
Leukotrienes are inflammatory mediators that actively participate in the inflammatory response and host defense against pathogens. However, leukotrienes also participate in chronic inflammatory diseases. 5-lipoxygenase is a key enzyme in the biosynthesis
Luc H. Boudreau, Grégoire Lassalle-Claux, Marc Cormier, Sébastien Blanchard, Marco S. Doucet, Marc E. Surette, Mohamed Touaibia   +6 more
doaj   +1 more source

A Nano-Liposomal Formulation of Caffeic Acid Phenethyl Ester Modulates Nrf2 and NF-κβ Signaling and Alleviates Experimentally Induced Acute Pancreatitis in a Rat Model

Antioxidants, 2022
The currently available management strategies for acute pancreatitis are inadequately effective which calls for exploration of new approaches to treat this condition.
Nancy Nabil Shahin, R. Shamma, I. S. Ahmed   +2 more
semanticscholar   +1 more source

Caffeic acid phenethyl ester (CAPE): pharmacodynamics and potential for therapeutic application [PDF]

Pharmacia, 2019
Caffeic acid phenethyl ester (CAPE) is the major pharmacologically-active component of some propolis types, rich in polyphenols, such as poplar propolis types.
Yordan Yordanov
doaj   +3 more sources

Activity of Caffeic Acid Phenethyl Ester in Caenorhabditis Elegans [PDF]

Future Medicinal Chemistry, 2016
Caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE), the major constituent of propolis, is able to increase the survival of the nematode Caenorhabditis elegans after infection with the fungal pathogen Candida albicans.CAPE increases the expression of several antimicrobial proteins involved in the immune response to C. albicans.
Jeffrey J, Coleman, Tomomi, Komura, Julia, Munro, Michael P, Wu, Rakhee R, Busanelli, Angela N, Koehler, Méryl, Thomas, Florence F, Wagner, Edward B, Holson, Eleftherios, Mylonakis   +9 more
openaire   +2 more sources

A Low Dose Combination of Withaferin A and Caffeic Acid Phenethyl Ester Possesses Anti-Metastatic Potential In Vitro: Molecular Targets and Mechanisms

Cancers, 2022
Simple Summary Cancer therapy suffers from its high cost and high rate of adverse effects and relapse of the disease. Hence, the new (preferably natural), economic and safer therapeutic as well preventive measures have been on demand and have been ...
A. N. Sari, J. Dhanjal, A. Elwakeel, Vipul Kumar, H. N. Meidinna, Huayue Zhang, Y. Ishida, K. Terao, D. Sundar, S. Kaul, R. Wadhwa   +10 more
semanticscholar   +1 more source

Glycosylation Enhances the Physicochemical Properties of Caffeic Acid Phenethyl Ester

Journal of Microbiology and Biotechnology, 2017
In this study, we synthesized a glycosylated derivative of caffeic acid phenethyl ester (CAPE) using the amylosucrase from Deinococcus geothermalis with sucrose as a substrate and examined its solubility, chemical stability, and anti-inflammatory activity.
Keum-Ok, Moon, Soyoon, Park, Myungsoo, Joo, Ki-Tae, Ha, Nam-In, Baek, Cheon-Seok, Park, Jaeho, Cha   +6 more
openaire   +2 more sources

Caffeic Acid Esters Are Effective Bactericidal Compounds Against Paenibacillus larvae by Altering Intracellular Oxidant and Antioxidant Levels

Biomolecules, 2019
American Foulbrood (AFB) is a deadly bacterial disease affecting pupal and larval honey bees. AFB is caused by the endospore-forming bacterium Paenibacillus larvae (PL).
William Collins, Noah Lowen, David J. Blake   +2 more
doaj   +1 more source

The Antitumor Effect of Caffeic Acid Phenethyl Ester by Downregulating Mucosa-Associated Lymphoid Tissue 1 via AR/p53/NF-κB Signaling in Prostate Carcinoma Cells

Cancers, 2022
Simple Summary The effect of caffeic acid phenethyl ester (CAPE) on prostate cancer has not been thoroughly explored. CAPE downregulated the expression of androgen receptor (AR) and mucosa-associated lymphoid tissue 1 (MALT1) but enhanced that of p53 ...
K. Chang, K. Tsui, S. Hsu, Hsin‐Ching Sung, Yu-Hsiang Lin, Chen-Pang Hou, Pei-Shan Yang, Chien-Lun Chen, Tsui-hsia Feng, H. Juang   +9 more
semanticscholar   +1 more source