Results 191 to 200 of about 7,901 (216)

Effects of caffeic acid phenethyl ester on cisplatin ototoxicity.

B-ENT, 2018
To report histological and electrophysiological data in rats treated with cisplatin and caffeic acid phenethyl ester.We randomly divided 28 Wistar rats into four groups of seven, to be treated as follows: control (saline), cisplatin, CAPE and cisplatin-CAPE.
Ozbay, M., Sengul, E., Kinis, V., Alabalik, U., Yilmaz, B., Topcu, I.   +5 more
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Caffeic acid phenethyl ester attenuates indomethacin-induced gastric ulcer in rats

Naunyn-Schmiedeberg's Archives of Pharmacology, 2023
Gastric ulcer is one of the most frequent gastrointestinal ailments worldwide. Indomethacin, one of the most potent NSAIDs, suffers undesirable ulcerogenic activity. Caffeic acid phenethyl ester (CAPE) has known health benefits. The current study examined the potential of CAPE to combat indomethacin-induced gastric ulcers in rats.
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Radio-Modulatory Potential of Caffeic Acid Phenethyl Ester: A Therapeutic Perspective

Anti-Cancer Agents in Medicinal Chemistry, 2018
Background: Use of natural agents is an upcoming area of research in cancer biology. Caffeic acid phenethyl ester (CAPE) has received great attention because of its therapeutic potential in various conditions including cancer. It is an active/abundant component of propolis, a honey bee hive product produced by bees using their enzyme-rich digestive ...
Km, Anjaly, Ashu B, Tiku
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Effect of caffeic acid phenethyl ester on corneal neovascularization in rats

Current Eye Research, 2001
Caffeic acid phenethyl ester (CAPE), a biologically active component of propolis from honeybee hives, has potent antiinflammatory and antioxidant properties. We aimed to evaluate the ability of topically applied CAPE in comparison with known steroidal (dexamethasone sodium phosphate) and nonsteroidal (indomethacin) topical agents to reduce corneal ...
Y, Totan, E, Aydin, O, Cekiç, M, Cihan Dağloğlu, M, Borazan, K, Dağlioğlu, A, Gültek   +6 more
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The protective role of caffeic acid phenethyl ester against streptomycin ototoxicity

American Journal of Otolaryngology, 2013
The aim of this experimental study was to investigate the efficacy of caffeic acid phenethyl ester (CAPE) in the prevention of streptomycin-induced ototoxicity.Thirty-two adult Wistar albino rats were divided into 4 groups: control (n = 8), streptomycin (n = 8), CAPE (n = 8), and streptomycin + CAPE (n = 8).
Salih, Bakır, Musa, Özbay, Ramazan, Gün, Ediz, Yorgancılar, Vefa, Kınış, Ayşenur, Keleş, Abdurrahman, Abakay, Osman, Gökalp, İsmail, Topçu   +8 more
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The flavanoide caffeic acid phenethyl ester blocks 6-hydroxydopamine-induced neurotoxicity

Neuroscience Letters, 2005
Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic (DA) neurons of the substantia nigra pars compacta. 6-Hydroxydopamine (6-OHDA) is specific to dopaminergic neurons in intrastriatal rodent models. It induces neuronal death either via uncoupling mitochondrial oxidative phosphorylation resulting in
Carmen, Noelker, Michael, Bacher, Petra, Gocke, Xing, Wei, Thomas, Klockgether, Yansheng, Du, Richard, Dodel   +6 more
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Caffeic acid phenethyl ester attenuates IgE-induced immediate allergic reaction

Inflammopharmacology, 2012
Caffeic acid phenethyl ester (CAPE) is the active component of honey bee propolis extracts. The results of the current study demonstrate that CAPE attenuated immunoglobulin (Ig)E-mediated allergic response in mast cells. Oral administration of CAPE inhibited IgE-mediated passive cutaneous anaphylaxis.
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Caffeic acid phenethyl ester prevents cadmium-induced cardiac impairment in rat

Toxicology, 2006
Caffeic acid phenethyl ester (CAPE), a flavonoid like compound, is one of the major components of honeybee propolis. It was found to be a potent free radical scavenger and antioxidant recently. The aim of this study was to examine the effect of CAPE on cadmium (Cd)-induced hypertension and cardiomyopathy in rats.
Mollaoglu, Hakan, Gokcimen, Alpaslan, Ozguner, Fehmi, Oktem, Faruk, Koyu, Ahmet, Kocak, Ahmet, Demirin, Hilmi, Gokalp, Osman, Cicek, Ekrem   +8 more
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Caffeic acid phenethyl ester suppresses oxidative stress in 3T3-L1 adipocytes

Journal of Asian Natural Products Research, 2013
The generation of oxidative stress, characterized by enhanced reactive oxygen species (ROS) formation, has been found in obesity. ROS production was increased during the differentiation of 3T3-L1 cells into adipocytes. We previously reported that caffeic acid phenethyl ester (CAPE) suppresses 3T3-L1 differentiation to adipocytes through the inhibition ...
Naomi, Yasui, Emi, Nishiyama, Sachiko, Juman, Hiroko, Negishi, Tomohiro, Miki, Yukio, Yamori, Katsumi, Ikeda   +6 more
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Caffeic Acid Phenethyl Ester: A Potential Therapeutic Cancer Agent?

Current Medicinal Chemistry
Background: Propolis and its major phenolic compound, caffeic acid phenethyl ester (CAPE), have garnered considerable scientific interest due to their anti- inflammatory properties and potential therapeutic applications. Objectives: This narrative review explores the potential utility of CAPE in cancer treatment.
Bjørklund, Geir, Storchylo, Olha, Peana, Massimiliano, Hangan, Tony, Lysiuk, Roman, Lenchyk, Larysa, Koshovyi, Oleh, Antonyak, Halyna, Hudz, Nataliia, Chirumbolo, Salvatore   +9 more
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