Results 51 to 60 of about 265,014 (287)

An Open‐Source Pipeline for Calcium Imaging and All‐Optical Physiology in Human Stem Cell‐Derived Neurons

Advanced Science, EarlyView.
This work introduces an open‐source all‐optical platform for functional phenotyping of human stem cell‐derived neurons. The system integrates optogenetics, calcium imaging, automated acquisition, and analysis to resolve single‐cell and network activity, enabling longitudinal measurements, disease modeling, and pharmacological screening in preclinical ...
Wardiya Afshar‐Saber, Federico M. Gasparoli, Ziqin Yang, Nicole A. Teaney, Rachel Hobson, Lahin Lalani, Gayathri Srinivasan, Dosh Whye, Ranit Karmakar, Elizabeth D. Buttermore, Kellen D. Winden, Cidi Chen, Mustafa Sahin   +12 more
wiley   +1 more source

Estimate the prevalence of daily caffeine consumption, caffeine use disorder, caffeine withdrawal and perceived harm in Iran: a cross-sectional study

Scientific Reports
One of the informal diagnoses in DSM-5 is Caffeine Use Disorder (CUD). CUD and high levels of caffeine consumption could impact mental health conditions.
Fatemeh Abdoli, Mohammadreza Davoudi, Fereshte Momeni, Farhang Djafari, Behrooz Dolatshahi, Samaneh Hosseinzadeh, Hajar Aliyaki, Zahra Khalili   +7 more
doaj   +1 more source

Caffeine metabolites are associated with different forms of caffeine supplementation and with perceived exertion during endurance exercise

Biology of Sport, 2020
This investigation compared the urine caffeine metabolites produced from different forms of caffeine supplementation given to runners 15 minutes before a series of 5-km running trials. Fourteen amateur competitive runners completed a series of self-paced
Peter Whalley, Carl Paton, Chey G. Dearing   +2 more
doaj   +1 more source

Combined Effects of Optimism Level and Caffeine Intake on QEEG Alpha Wave Power: A Pilot Study [PDF]

, 2016
Caffeine has a general effect on alpha brain waves (Diukova, 2010). Heavy caffeine users experienced increased neural activity compared to vasoconstriction (Gilbert et al., 2000). Purpose of the pilot study is to assess the effects of caffeine intake and
Aguerrevere, Luis E., Lenert, Melissa
core   +1 more source

Transdermal evaluation of caffeine in different formulations and excipients [PDF]

, 2013
Background: The stratum corneum(SC) forms adifficultphysical barrier fordrugs to pass through the skin. Several strategieswere developed to overcome this barrier.Optimization of topical drug formulations by selected excipients may facilitate the ...
Boonen, Jente, Burvenich, Christian, De Spiegeleer, Bart, Mehuys, Els, Peremans, Kathelijne, Remon, Jean Paul, Roche, Nathalie, Veryser, Lieselotte   +7 more
core   +2 more sources

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Pharmacology of caffeine and its effects on the human body

European Journal of Medicinal Chemistry Reports
Caffeine is the world's most popular stimulant and psychoactive substance. Given the ubiquitous use of caffeine, it is crucial for us to comprehend how our body interacts with caffeine. The pharmacokinetics of caffeine and its action mechanisms have been
Vundrala Sumedha Reddy, S. Shiva, Srinidhi Manikantan, Seeram Ramakrishna   +3 more
doaj   +1 more source

Effects of Caffeine on Maximum Bench Press Repetitions [PDF]

, 2011
The purpose of this research is to study the effects of caffeine on the maximum amount bench press repetitions performed. Blood pressure and heart rate will also be measured. This research is important because of the popular use of caffeine among college
Soller, Alex
core   +1 more source

Caffeine. cognitive and physical performance enhancer or psychoactive drug? [PDF]

, 2015
Caffeine use is increasing worldwide. The underlying motivations are mainly concentration and memory enhancement and physical performance improvement. Coffee and caffeine-containing products affect the cardiovascular system, with their positive inotropic
Aromatario, Mariarosaria, Cappelletti, Simone, Piacentino, Daria, Sani, Gabriele   +3 more
core   +1 more source

Protection and Delivery of Phytochemicals from Passive Encapsulation to Guaranteed Self‐Assembly Induced by Amyloid Template for Chronic Disease Prevention via Modulating Microbial‐Host Crosstalk

Advanced Science, EarlyView.
ABSTRACT The rising incidence of chronic diseases globally has drawn widespread attention to phytochemicals, which exert targeted preventive and alleviating effect by modulating gut microbiota; thus, a potential strategy for precision nutritional interventions is offered.
Shiqi Bai, Siying Cheng, Fengguang Ma, Xiaorong Zhang, Jianan Huang, Zhonghua Liu, Bing Hu   +6 more
wiley   +1 more source