Results 171 to 180 of about 12,893 (221)

Natural products as potential anticonvulsants: Caffeoylquinic acids

Archives of Pharmacal Research, 2012
Current anticonvulsant therapies are generally directed at symptomatic treatment by suppressing excitability within the brain. Consequently, they have adverse effects such as cognitive impairment, dependence, and abuse. The need for more effective and less toxic anticonvulsants has generated renewed interest in natural products for the treatment of ...
Hyo Geun, Kim, Myung Sook, Oh
openaire   +2 more sources

Molecular docking of chlorogenic acid, 3,4-di-O-caffeoylquinic acid and 3,5-di-O-caffeoylquinic acid with human serum albumin

Journal of Chinese Integrative Medicine, 2012
To investigate the mechanism of binding of human serum albumin (HSA) with potential sensitinogen, including chlorogenic acid and two isochlorogenic acids (3,4-di-O-caffeoylquinic acid and 3,5-di-O-caffeoylquinic acid).By using the docking algorithm of computer-aided molecular design and the Molegro Virtual Docker, the crystal structures of HSA with ...
Jing, Zhou   +4 more
openaire   +2 more sources

Caffeoylquinic Acids: Separation Method, Antiradical Properties and Cytotoxicity

Chemistry & Biodiversity, 2019
AbstractTwelve chlorogenic acid derivatives and two flavones were isolated from Moquiniastrum floribundum (Asteraceae, other name: Gochnatia floribunda). Compounds were evaluated in relation to their cytotoxicity and antiradical properties. Cytotoxicity was not observed for compounds, however, chlorogenic acid derivatives showed antiradical activity ...
Cinthia Indy Tamayose   +4 more
openaire   +2 more sources

Inhibitory mechanism of xanthine oxidase activity by caffeoylquinic acids in vitro

International Journal of Biological Macromolecules, 2021
In this study, the inhibitory activities of eight caffeoylquinic acids (CQAs) against xanthine oxidase (XOD) in vitro were investigated, and the interaction mechanisms between each compound and XOD were studied. HPLC and fluorescence spectra showed that the inhibitory activities of dicaffeoylquinic acids (diCQAs) were higher than that of ...
Yin, Wan   +6 more
openaire   +2 more sources

Comparative study of the antioxidative activities of caffeoylquinic and caffeic acids

Food Chemistry, 2016
A detailed conformational analysis was performed to determine the most stable conformers of chlorogenic, cryptochlorogenic, and neochlorogenic acids. The simulated and experimental NMR spectra of caffeoylquinic acids are in excellent agreement. The bond dissociation enthalpies, proton affinities, electron transfer enthalpies, ionisation potentials, and
Svetlana, Marković, Jelena, Tošović
openaire   +2 more sources

CAFFEOYLQUINIC ACIDS BIOSYNTHESIS AND ACCUMULATION IN CYNARA CARDUNCULUS: STATE OF THE ART

Acta Horticulturae, 2013
Plant secondary metabolites are highly evolved compounds performing different functions, and have been widely exploited from food to medicine. A constant supply of phenols, a class of secondary metabolites, provides preventive and defensive mechanisms to reduce the risk of chronic diseases in human beings; among them mono- and di-caffeoylquinic acids ...
MOGLIA, Andrea   +8 more
openaire   +3 more sources

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