Results 161 to 170 of about 33,292 (260)

Redefining the Pathogenic CAG Repeat Units Threshold in CACNA1A for Spinocerebellar Ataxia Type 6. [PDF]

Neurol Genet
Hatano Y, Ishihara T, Hirokawa S, Date H, Takahashi Y, Mizusawa H, Onodera O.   +6 more
europepmc   +1 more source

Intrinsic pH chemosensitivity of acutely dissociated medullary serotonergic and retrotrapezoid neurones

The Journal of Physiology, EarlyView.
Abstract figure legend Central respiratory chemoreceptors (CRCs) are critical for maintaining normal systemic levels of pH and PCO2. A CRC must respond to pH via intrinsic mechanisms. Here we quantified intrinsic chemosensitivity of medullary 5‐HT neurones and retrotrapezoid nucleus (RTN) neurones using acute dissociation.
Yuanming Wu, Eduardo Bravo, George Bradley Richerson   +2 more
wiley   +1 more source

Correction to 'DNA extrusion size determines pathway choice during CAG repeat expansion'. [PDF]

Nucleic Acids Res
europepmc   +1 more source

Complex cognitive and motivational deficits precede motor dysfunction in the zQ175 (190 CAG repeat) Huntington's disease model. [PDF]

Exp Neurol
Harrison DJ, Linehan P, Patel Y, Bayram-Weston Z, Rosser AE, Dunnett SB, Brooks SP, Lelos MJ.   +7 more
europepmc   +1 more source

Voltage‐gated potassium channels mediate thyroid hormone control of skeletal muscle excitability

The Journal of Physiology, EarlyView.
Abstract figure legend Thyroid hormone (TH)‐dependent remodelling of potassium (K+) channel networks regulates skeletal muscle (SkM) excitability. Triiodothyronine (T3), locally generated from thyroxine (T4) by type 2 deiodinase (D2), binds thyroid hormone receptors (TRα/β) and modulates transcription via thyroid response elements (TREs).
Annarita Nappi, Caterina Miro, Annunziata Gaetana Cicatiello, Ilaria Piccialli, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Rosa Sirica, Melania Murolo, Emery Di Cicco, Daniela Terracciano, Anna Pannaccione, Monica Dentice   +12 more
wiley   +1 more source

Establishment of a humanized SCA2 mouse model carrying a CAA disruption preventing CAG repeat expansion in pathogenic genes. [PDF]

Animal Model Exp Med
Zhang Y, Li Y, Zhang L, Li Z, Lin K, Huang K, Yang Z, Ma S, Sun H, Zhang X.   +9 more
europepmc   +1 more source

CX3CR1 Modulates Migration of Resident Microglia Towards Cortical Laser‐Induced Lesions

Glia, Volume 74, Issue 10, October 2026.
CX3CR1 deficiency promotes microglial migration toward CNS injury. Proteomic profiling reveals altered RHO‐mediated cytoskeletal signaling, while in vivo two‐photon imaging demonstrates increased process extension, velocity, and accumulation of Cx3cr1‐deficient microglia at lesion sites. ABSTRACT Microglia are innate immune cells of the central nervous
Jens Wagner, Henrike Antony, Cornelia Hoyer, Kristiina Lundgrén, Rabah Soliymani, Sophie Crux, Lena Justus, Kevin Keppler, Julia Steffen, Christian Kurts, Daniel R. Engel, Jochen Herms, Maciej Łałowski, Martin Fuhrmann   +13 more
wiley   +1 more source

Isotopic H/D Exchange in Hydrogen Bonds Between the Nitrogenous Bases of the CAG Repeat Tract Makes It Possible to Stabilize Its Expansion in the <i>ATXN2</i> Gene. [PDF]

Biomedicines
Dorohova A, Velázquez-Pérez L, Drobotenko M, Lyasota O, Hernandez-Caceres JL, Rodriguez-Labrada R, Svidlov A, Leontyeva O, Nechipurenko Y, Dzhimak S.   +9 more
europepmc   +1 more source

Gq Signaling in Microglia Triggers Interferon Responses and Improves Outcome After Ischemic Stroke

Glia, Volume 74, Issue 10, October 2026.
Chemogenetic activation of Gq signaling in microglia ahead of ischemic stroke reduces infarct size in mice. Seven days after stroke, Gq‐primed microglia in the penumbra show enhanced interferon responses, altered branching patterns, and reduced phagocytosis.
Lynn Bitar, Marie‐Luise Brehme, Charlotte Oldenburg, Sara Isla Cainzos, Michael G. Kaul, Tobias Mummert, Malte Borggrewe, Thomas G. Oertner, Tim Magnus   +8 more
wiley   +1 more source

A Super‐Resolution Approach for Astrocyte‐Specific Molecular Imaging Reveals the Nanoscale Distribution of Monoacylglycerol Lipase, the Metabolic Node Between Endocannabinoid and Prostaglandin Signaling

Glia, Volume 74, Issue 9, September 2026.
Dual‐color STORM resolves the precise architecture and protein distributions within hippocampal astrocytes at the nanoscale. Identification of a sparse but specific MAGL pool in CA1 astrocytic processes. Astrocytic MAGL is not synapse‐associated, suggesting a synapse‐independent role.
Miklós Zöldi, István Katona
wiley   +1 more source