Results 181 to 190 of about 33,292 (260)

Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington's disease decades before clinical motor diagnosis. [PDF]

Nat Med
Scahill RI, Farag M, Murphy MJ, Hobbs NZ, Leocadi M, Langley C, Knights H, Ciosi M, Fayer K, Nakajima M, Thackeray O, Gobom J, Rönnholm J, Weiner S, Hassan YR, Ponraj NKP, Estevez-Fraga C, Parker CS, Malone IB, Hyare H, Long JD, Heslegrave A, Sampaio C, Zhang H, Robbins TW, Zetterberg H, Wild EJ, Rees G, Rowe JB, Sahakian BJ, Monckton DG, Langbehn DR, Tabrizi SJ.   +32 more
europepmc   +1 more source

Surviving Fibroblasts After Treatment With Mitomycin C Exhibit SASP‐Like Phenotype After Glaucoma Filtration Surgery

Aging Cell, Volume 25, Issue 9, September 2026.
Transcriptomic analysis using a rabbit glaucoma filtration surgery model, combined with in vitro experiments on human conjunctival fibroblasts, demonstrates that mitomycin C induces a senescence‐associated secretory phenotype (SASP)‐like state. These SASP‐like fibroblasts were selectively eliminated by the specific senolytic agent, highlighting their ...
Akitoshi Kimura, Tomokazu Fujimoto, Satoshi Iraha, Kei‐Ichiro Yasunaga, Miyuki Inoue‐Mochita, Naofumi Funagura, Shunsuke Tanigawa, Daisuke Kurotaki, Tomoaki Koga, Fumika Watanabe‐Kitamura, Utako Tsutsumi‐Kuroda, Mitsuyoshi Nakao, Toshihiro Inoue   +12 more
wiley   +1 more source

CAG repeat mosaicism is gene specific in spinocerebellar ataxias. [PDF]

Am J Hum Genet
Kacher R, Lejeune FX, David I, Boluda S, Coarelli G, Leclere-Turbant S, Heinzmann A, Marelli C, Charles P, Goizet C, Kabir N, Hilab R, Jornea L, Six J, Dommergues M, Fauret AL, Brice A, Humbert S, Durr A.   +18 more
europepmc   +1 more source

Upskilling Allied Health Professionals and Judo Coaches to Teach Safe Falling Skills to Older Adults: A Train‐the‐Trainer Intervention

Australasian Journal on Ageing, Volume 45, Issue 3, September 2026.
ABSTRACT Objectives Learning safe falling skills, adapted from judo, is a promising strategy to reduce the risk of falls and fall‐related injuries in older adults. This study aimed to upskill allied health professionals and judo coaches to teach safe falling skills to community‐dwelling older adults.
Agathe Daria Jadczak, Meera Verma, Michael Headland, Renuka Visvanathan   +3 more
wiley   +1 more source

Semen Quality in Transgender Individuals Seeking Fertility Preservation

Andrology, Volume 14, Issue 6, Page 1771-1776, September 2026.
ABSTRACT Background Transgender individuals assigned male at birth (AMAB) may choose to preserve their fertility prior to starting gender‐affirming hormone therapy (GAHT). However, limited data exist regarding the baseline reproductive and hormonal characteristics of this population before and after GAHT.
Maurizio De Rocco Ponce, Eden Troka, Massimiliano Raffo, Luis Miguel Malca Caballero, Alberto Ferlin, Andrea Salonia, Eduard Ruiz Castañé, Alberto Scala, Andrea Garolla, the Gender Incongruence Interdisciplinary Group (GIIG), Andrea Garolla, Anna Aprile, Camillo Barbisan, Anna Belloni Fortina, Valentina Camozzi, Elena Campello, Annamaria Cattelan, Chiara Ceolin, Fabrizio Dal Moro, Giorgio De Conti, Angela Favaro, Alberto Ferlin, Francesco Francini Pesenti, Michela Gatta, Marta Ghisi, Sandro Giannini, Laura Guazzarotti, Massimo Iafrate, Paolo Meneguzzo, Marina Miscioscia, Giulia Musso, Giancarlo Ottaviano, Corrado Marchese Ragona, Carlo Saccardi, Lolita Sasset, Rossana Schiavo, Giuseppe Sergi, Paolo Simioni, Benedetta Tascini, Eleonora Vania, Elisa Varotto, Francesca Venturini, Tommaso Vezzaro, Fabrizio Vianello   +43 more
wiley   +1 more source

The DNA/RNA autophagy protein SIDT2 as a novel neuropathological hallmark in Huntington disease

Brain Pathology, Volume 36, Issue 5, September 2026.
SIDT2‐immunoreactive inclusions are observed in the striatum, cerebral cortex, and hypothalamus in HD cases with different Vonsattel grades, and the frequency of SIDT2‐immunoreactive inclusions is associated with longer CAG repeats in the huntingtin gene.
Sanaz Gabery, Sofia Bergh, Chrisovalantou Huridou, Rachel Y. Cheong, Barbara Baldo, Paul Günther Scheunemann, Marie‐Louisa Schoebel, Linda Holmquist Mengelbier, Elisabet Englund, Catriona McLean, Carsten Saft, Deniz Kirik, Maria Björkqvist, Glenda Halliday, Elisabeth Petrasch‐Parwez, Huu Phuc Nguyen, Jonasz Jeremiasz Weber, Åsa Petersén   +17 more
wiley   +1 more source

Dysregulation of alternative splicing is a transcriptomic feature of patient-derived fibroblasts from CAG repeat expansion spinocerebellar ataxias. [PDF]

Hum Mol Genet
Aliyeva A, Lennon CD, Cleary JD, Shorrock HK, Berglund JA.   +4 more
europepmc   +1 more source

Aquaculture Systems Affect the Impact of Probiotics, Prebiotics, and Synbiotics on Growth and Immunity of Oreochromis niloticus: A Systematic Review and Meta‐Analysis

Reviews in Aquaculture, Volume 18, Issue 4, September 2026.
Probiotics reliably improve growth, feed efficiency, and immunity in Nile tilapia, with closed systems showing the most consistent benefits. ABSTRACT Tilapia (Oreochromis niloticus) aquaculture is expanding worldwide, yet disease, environmental variability, and the need for sustainable production remain major challenges.
Diego Cardenas Laverde, Ruth Yolanda Ruiz Pardo, Luisa Marcela Villamil Diaz   +2 more
wiley   +1 more source

Huntingtin CAG repeat size variations below the Huntington's disease threshold: associations with depression, anxiety and basal ganglia structure. [PDF]

Eur J Hum Genet
Vater M, Rost N, Eckstein G, Sauer S, Tontsch A, Erhardt A, Lucae S, Brückl T, Klopstock T, Sämann PG, Binder EB.   +10 more
europepmc   +1 more source

Wnt3a Downregulation Contributes to Type 2 Diabetes Mellitus by Impairing Pancreatic β‐Cell Function

The FASEB Journal, Volume 40, Issue 16, 31 August 2026.
Wnt3a downregulation is associated with type 2 diabetes mellitus (T2DM) in clinical patients and high‐fat diet (HFD)‐induced mouse models. In MIN6 pancreatic β‐cells, knockdown of Wnt3a impairs insulin secretion and β‐cell function under insulin‐resistant conditions, while recombinant Wnt3a treatment rescues these defects.
Yilinuer Adeerjiang, Xiao‐Xue Gan, Ran‐Ru Wang, Sheng Jiang, Guo‐Li Du   +4 more
wiley   +1 more source