Results 51 to 60 of about 5,149,759 (252)

Targeted inhibition of PTPN22 is a novel approach to alleviate osteogenic responses in aortic valve interstitial cells and aortic valve lesions in mice

BMC Medicine, 2023
Background Calcific aortic valve disease (CAVD) is the most prevalent valvular disease and has high morbidity and mortality. CAVD is characterized by complex pathophysiological processes, including inflammation-induced osteoblastic differentiation in ...
Shunyi Li, Zichao Luo, Shuwen Su, Liming Wen, Gaopeng Xian, Jing Zhao, Xingbo Xu, Dingli Xu, Qingchun Zeng   +8 more
doaj   +1 more source

Sex-Specific Cell Types and Molecular Pathways Indicate Fibro-Calcific Aortic Valve Stenosis

Frontiers in Immunology, 2022
BackgroundAortic stenosis (AS) is the most common valve disorder characterized by fibro-calcific remodeling of leaflets. Recent evidence indicated that there is a sex-related difference in AS development and progression.
Veronika A. Myasoedova, Ilaria Massaiu, Ilaria Massaiu, Donato Moschetta, Donato Moschetta, Mattia Chiesa, Mattia Chiesa, Paola Songia, Vincenza Valerio, Vincenza Valerio, Valentina Alfieri, Romain Capoulade, Daniela Trabattoni, Daniele Andreini, Daniele Andreini, Elvira Mass, Valentina Parisi, Paolo Poggio   +17 more
doaj   +1 more source

Integrated Analysis of LncRNA-Mediated ceRNA Network in Calcific Aortic Valve Disease

Cells, 2022
Background: The high morbidity and mortality of calcific aortic valve disease (CAVD) represents an unmet clinical need to investigate the molecular mechanisms involved.
Long Chen, Ke Wei, Jun Li, Yue Li, Huiqing Cao, Zhe Zheng   +5 more
doaj   +1 more source

Comparative evaluation of left ventricular mass regression after aortic valve replacement: a prospective randomized analysis [PDF]

, 2011
Background: We assessed the hemodynamic performance of various prostheses and the clinical outcomes after aortic valve replacement, in different age groups.
Wood Jeffrey P, Doss, Mirko, Moritz Anton, Arndt H Kiessling, Mirko Doss, Kiessling, Arndt Holger, Anton Moritz, Jeffrey P Wood, Wood, Jeffrey P., Moritz, Anton, Doss Mirko, Kiessling Arndt H   +11 more
core   +2 more sources

Transcriptomic profiling of calcified aortic valves in clonal hematopoiesis of indeterminate potential carriers

Scientific Reports, 2022
Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by the presence of clones of mutated blood cells without overt blood diseases.
Francesco Vieceli Dalla Sega, Domenico Palumbo, Francesca Fortini, Ylenia D’Agostino, Paolo Cimaglia, Luisa Marracino, Paolo Severi, Oriana Strianese, Roberta Tarallo, Giovanni Nassa, Giorgio Giurato, Giovanni Pecoraro, Serena Caglioni, Elisa Mikus, Alberto Albertini, Gianluca Campo, Roberto Ferrari, Paola Rizzo, Alessandro Weisz, Francesca Rizzo   +19 more
doaj   +1 more source

Progress on long non-coding RNAs in calcific aortic valve disease [PDF]

Frontiers in Cardiovascular Medicine
Shen Y, Li J, Zhao Z, Chen X.
exaly   +2 more sources

Role of Runx2 in Calcific Aortic Valve Disease in Mouse Models

Frontiers in Cardiovascular Medicine, 2021
Background: Calcific aortic valve disease is common in the aging population and is characterized by the histological changes of the aortic valves including extracellular matrix remodeling, osteochondrogenic differentiation, and calcification.
Subramanian Dharmarajan, Mei Y. Speer, Kate Pierce, Jake Lally, Elizabeth M. Leaf, Mu-En Lin, Marta Scatena, Cecilia M. Giachelli   +7 more
doaj   +1 more source

Lithotripsy of Calcified Aortic Valve Leaflets by a Novel Ultrasound Transcatheter-Based Device

Frontiers in Cardiovascular Medicine, 2022
The increasing incidence of calcific aortic valve disease necessitates the elaboration of new strategies to retard the progression of the pathology with an innovative solution. While the increasing diffusion of the transcatheter aortic valve replacements
Giacomo Bernava, Enrico Fermi, Guido Gelpi, Stefano Rizzi, Davide Benettin, Marianna Barbuto, Claudia Romagnoni, Domenico Ventrella, Maria Chiara Palmieri, Marco Agrifoglio, Gianluca Polvani, Maria Laura Bacci, Enrico Pasquino, Maurizio Pesce   +13 more
doaj   +1 more source

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

Non-linear finite element analyses of the aortic heart valve [PDF]

, 2004
Includes bibliographical references.Finite element models of the aortic heart valve have been successfully used in the past to gain insight into the mechanics of the valve and to aid in understanding of valve failure.
Koch, Thorsten M
core   +1 more source