Results 271 to 280 of about 78,892 (304)
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1996
Abstract Calcineurin (Cn) is a Ca2+/calmodulin-dependent protein phosphatase, composed of a catalytic and a regulatory subunit. It has been found in the brain, where it is one of the most abundant calmodulin-binding proteins. Recently it was demonstrated that calcineurin is the target of immunosuppressant drugs (cyc ...
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Abstract Calcineurin (Cn) is a Ca2+/calmodulin-dependent protein phosphatase, composed of a catalytic and a regulatory subunit. It has been found in the brain, where it is one of the most abundant calmodulin-binding proteins. Recently it was demonstrated that calcineurin is the target of immunosuppressant drugs (cyc ...
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Calcineurin as a Multifunctional Regulator
Journal of Biochemistry, 2002Long recognized as an important regulatory mechanism in biosignal processes, modulation of the phosphorylation state of proteins has emerged as the most important mechanism for understanding signal transduction. In contrast to the multitude of protein kinases and the clear signal transduction pathways, relatively few protein phosphatases are known and ...
Futoshi, Shibasaki +2 more
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Calcineurin—immunosuppressor complexes
Current Opinion in Structural Biology, 1996Crystal structures of the Ser/Thr phosphatase calcineurin (protein phosphatase 2B) have recently been solved by X-ray crystallography, both in the free-protein state, and complexed with the immunophilin/immunosuppressant FKBP12/FK506. Core elements of the calcineurin phosphatase have been found to be similar to the corresponding elements of Ser/Thr ...
B L, Stoddard, K E, Flick
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Calcineurin Inhibitor Encephalopathy
Seminars in Neurology, 2013Calcineurin inhibitor encephalopathy (CIE) is a rare condition occurring in patients who are undergoing treatment with drugs from the calcineurin inhibitor (CI) family of immunosuppressants, either cyclosporine (CsA) or tacrolimus (TAC, FK506). Generally acute in onset, the symptoms are commonly reversible if properly managed in a timely fashion.
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Remodeling muscles with calcineurin
BioEssays, 2000Ca(2+) signaling plays a central role in hypertrophic growth of cardiac and skeletal muscle in response to mechanical load and a variety of signals. However, the mechanisms whereby alterations in Ca(2+) in the cytoplasm activate the hypertrophic response and result in longterm changes in muscle gene expression are unclear.
E N, Olson, R S, Williams
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Dual Calcium Ion Regulation of Calcineurin by Calmodulin and Calcineurin B
Biochemistry, 1994The dependence of calcineurin on Ca2+ for activity is the result of the concerted action of calmodulin, which increases the turnover rate of the enzyme and modulates its response to Ca2+ transients, and of calcineurin B, which decreases the Km of the enzyme for its substrate.
P M, Stemmer, C B, Klee
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