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Calcineurin inhibitors in heart transplantation
The Journal of Heart and Lung Transplantation, 2004The use of calcineurin inhibitors (CNIs; cyclosporine and tacrolimus) has dramatically increased medium-term life expectancy after heart transplantation but has had only limited impact on long-term outcomes for heart transplant recipients. The original oil-based formulation of cyclosporine has been superceded by a microemulsion formulation (Neoral ...
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Calcineurin inhibitors in chronic urticaria
Current Opinion in Allergy & Clinical Immunology, 2012The purpose of the review is to review the pathophysiology, available data, and our current recommendations for calcineurin inhibitor (cyclosporine and tacrolimus) treatment in antihistamine refractory chronic idiopathic urticaria (CIU) patients.Low-dose cyclosporine (
Timothy D, Trojan, David A, Khan
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Hypertensinogenic mechanism of the calcineurin inhibitors
Current Hypertension Reports, 2002Kidney transplantation has seen a remarkable improvement in allograft survival rates and patient survival rates, and an equally remarkable reduction in acute rejection rates. Most attribute these changes to the introduction and widespread use of calcineurin inhibitors as part of the standard immunosuppressive regimen.
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Calcineurin inhibitors in oral medicine
Journal of the American Academy of Dermatology, 2009Topically applied calcineurin inhibitors have been suggested to be of some benefit in the treatment of immunologically mediated oral mucosal disorders, particularly oral lichen planus. This article reviews the current evidence of the efficacy and safety of topical calcineurin inhibitor agents in the management of different oral conditions.
Khalid A, Al Johani +3 more
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Replacing calcineurin inhibitors with mTOR inhibitors in children
Pediatric Transplantation, 2005Abstract: A highly selected subject group comprising pediatric recipients of liver (n = 36) and small intestine alone (n = 1) or multivisceral graft (n = 2) were converted to sirolimus maintenance therapy for tacrolimus‐related side effects (n = 32) or by primary intent (n = 7).
Rakesh, Sindhi +7 more
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Selective Targeting of Calcineurin Isoforms by Calcineurin Inhibitors
The FASEB Journal, 2020Background Calcineurin Inhibitors (CNIs) have increased one‐year and five‐year post‐transplantation survival rates to ~90% and ~75%, respectively. While CNIs have dramatically improved the quality of patient care, its side effects are also noteworthy: Long‐term CNI therapy is nephrotoxic and is a growing concern
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Calcineurin Inhibitors in Heart Transplantation
Transplantation Proceedings, 2005The calcineurin inhibitors (CNIs) cyclosporine and tacrolimus are routinely used for immunosuppression following heart transplantation in conjunction with an antiproliferative agent with or without maintenance steroids. In randomized multicenter trials both agents showed similar efficacies to prevent rejection and death within the first year after ...
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Calcineurin-inhibitor Pain Syndrome
The Clinical Journal of Pain, 2012There has been increased recognition of calcineurin, a phosphoprotein serine/threonine phosphatase enzyme, in the regulation of many physiologic systems. Calcineurin mediates activation of lymphocytes, which play a role in immune response. Widely distributed in the central nervous system, calcinuerin also plays an important role in sensory neural ...
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The Pharmacogenetics of Calcineurin Inhibitor–Related Nephrotoxicity
Therapeutic Drug Monitoring, 2010Chronic calcineurin inhibitor (CNI)-induced nephrotoxicity is associated with prolonged use of cyclosporine and tacrolimus and has been observed after all types of transplantation, as well as during treatment of autoimmune disease. Extensive alterations in the renal architecture including glomerular sclerosis, tubular atrophy and interstitial fibrosis ...
Hesselink, Dennis +2 more
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Molecular actions of calcineurin inhibitors
Drug News & Perspectives, 2003The immunosuppressive drugs cyclosporin A and FK-506, also called calcineurin inhibitors, have been useful for treating immune system-mediated diseases and have truly revolutionized allograft transplantation. Both drugs block T-cell proliferation by mechanisms that involve the inhibition of the key signaling phosphatase calcineurin, hence, the name ...
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