Results 61 to 70 of about 74,317 (300)

Determinants of circulating calcitonin value: analysis of thyroid features, demographic data, anthropometric characteristics, comorbidities, medications, and smoking habits in a population with histological full exclusion of medullary thyroid carcinoma

Frontiers in Oncology
ObjectiveCalcitonin (Ctn) measurement is crucial for the early diagnosis of medullary thyroid carcinoma (MTC). However, Ctn levels can be skewed/elevated due to other reasons, and the Ctn upper reference value remains controversial.
Pierpaolo Trimboli, Pierpaolo Trimboli, Giuseppe Peloni, Dorotea Confalonieri, Elena Gamarra, Tommaso Piticchio, Francesco Frasca, Petra Makovac, Arnoldo Piccardo, Lorenzo Ruinelli, Lorenzo Ruinelli, Lorenzo Ruinelli   +11 more
doaj   +1 more source

Phase 1, open‐label, randomized study of the elecoglipron pharmacokinetic profile in healthy participants under fed and fasted conditions

British Journal of Clinical Pharmacology, EarlyView.
Aims Elecoglipron (AZD5004/ECC5004) is an oral small‐molecule glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA) in development for weight management in people living with obesity or overweight and type 2 diabetes. This study aimed to characterize the pharmacokinetics (PK) profiles of two formulations of elecoglipron under fed and fasted conditions ...
Jianfeng Xu, Amina Haggag, Laurie Butcher, Haihui Liu, Wen Chen, Xuefeng Sun, Aruni Jha, Hongtao Yu, Anis Khan, Victoria E. R. Parker, Christer Tannergren, Xiaoliang Pan, Jianfeng Xu, Jingye Zhou   +13 more
wiley   +1 more source

Glycosylation reduces the bioactivity of calcitonin

, 1989
The biological significance of peptide hormone glycosylation is uncertain. To examine the effect of Asn-linked glycosylation on calcitonin's bioactivity we purified glycosylated calcitonin from a transplantable rat medullary thyroid carcinoma ...
Roos, Bernard A, Birnbaum, Roger S, Gkonos, Peter J, Charbonneau, Harry, Howard, Guy A, Lawson, Phillip T   +5 more
core   +1 more source

Sporadic calcitonin-negative medullary thyroid carcinoma is not more aggressive than its classic counterpart: case report and review of the literature

Revista Colombiana de Endocrinología, Diabetes y Metabolismo, 2017
Objective: medullary thyroid carcinoma (MTC) with normal serum basal calcitonin (calcitonin-negative MTC) is uncommon. The exact mechanism for this paradox is unclear.
John J. Orrego, Joseph A. Chorny
doaj   +1 more source

Chronic Electrical Stimulation of the Superior Laryngeal Nerve in the Rat: A Potential Therapeutic Approach for Postmenopausal Osteoporosis

Biomedicines, 2020
Electrical stimulation of myelinated afferent fibers of the superior laryngeal nerve (SLN) facilitates calcitonin secretion from the thyroid gland in anesthetized rats.
Kaori Iimura, Nobuhiro Watanabe, Philip Milliken, Yee-Hsee Hsieh, Stephen J. Lewis, Arun Sridhar, Harumi Hotta   +6 more
doaj   +1 more source

Calcitonin and calcitonin receptors: bone and beyond

International Journal of Experimental Pathology, 2000
Calcitonin (CT), a 32 amino acid peptide hormone produced primarily by the thyroid, and its receptor (CTR) are well known for their ability to regulate osteoclast mediated bone resorption and enhance Ca2+ excretion by the kidney. However, recent studies now suggest that CT and CTRs may play an important role in a variety of processes as wide ranging as
openaire   +3 more sources

Calcitonin-Producing Neuroendocrine Neoplasms of the Pancreas: Clinicopathological Study of 25 Cases and Review of the Literature [PDF]

, 2017
Increased levels of circulating calcitonin are a clue in the diagnosis of medullary thyroid carcinoma. However, hypercalcitoninemia can also be related to other pathological conditions, including pancreatic neuroendocrine neoplasms (PanNENs).
Sessa, Fausto, Roberta Maragliano, Fausto Sessa, Uccella, Silvia, Perren, A., La Rosa, S., La Rosa, Stefano, Silvia Uccella, Maragliano, Roberta, Maragliano, R., Blank, Annika, Sessa, F., Blank, A., Aurel Perren, Annika Blank, Stefano La Rosa, Uccella, S., Perren, Aurel, La Rosa S, Blank A, Perren A, Uccella S, Maragliano R, Sessa F   +23 more
core   +2 more sources

CORRELATION OF AGE AND SEX IN RELATION TO SERUM CALCITONIN, CREATININE AND URIC ACID ON CKD PATIENTS WITH THYROID ABNORMALITY COMPLICATION

, 2023
: This study evaluated the serum calcitonin, creatinine and uric acid levels in chronic kidney diseases (CKD) complicated by dysthyroidism. A total of 119 participants were recruited in this study, majority of who were males. Majority of the participants
Christian Ugege, Olaniyi O.D., Ohiwerei W.O.,, Otaye, O.M, Eidangbe, A.P, Ogedegbe, I.S   +5 more
core   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations

International Journal of Endocrinology, 2020
Calcitonin was discovered as a peptide hormone that was known to reduce the calcium levels in the systemic circulation. This hypocalcemic effect is produced due to multiple reasons such as inhibition of bone resorption or suppression of calcium release ...
Jingbo Xie, Jian Guo, Zaeema Kanwal, Mingzheng Wu, Xiangyang Lv, Nihal Abdalla Ibrahim, Ping Li, Manal Ali Buabeid, El-Shaimaa A. Arafa, Qingshan Sun   +9 more
doaj   +1 more source