Results 91 to 100 of about 11,435,493 (279)

Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies [PDF]

, 2012
Modelling class B G-protein-coupled receptors (GPCRs) using class A GPCR structural templates is difficult due to lack of homology. The plant GPCR, GCR1, has homology to both class A and class B GPCRs. We have used this to generate a
Poyner, David, Reynolds, Christopher A., Hay, Debbie L., Poyner, David R, Barwell, James, Upton, Graham J.G., Poyner, David R., Reeves, Philip J., Upton, Graham J. G., Taddese, Bruck, Reeves, Philip J, Reynolds, Christopher A, Conner, Alex C., Hay, Debbie L, Conner, Alex C, Vohra, Shabana, Upton, Graham JG   +16 more
core   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Demographic and Characteristics of Primary Headache in Egyptian Epileptic Patients [PDF]

Zagazig University Medical Journal
Background: Migraine pathophysiology has been linked to neuroinflammation. During a migraine attack, trigeminal activation results in the release of calcitonin gene-related peptide (CGRP), which stimulates the release of inflammatory cytokines and plays ...
Amal Elmotayam, Hanan Mohammed, Marwan Saleh, Abdelrahman Fahmy   +3 more
doaj   +1 more source

Endogenous α-calcitonin-gene-related peptide promotes exercise-induced, physiological heart hypertrophy in mice [PDF]

, 2014
AIM: It is unknown how the heart distinguishes various overloads, such as exercise or hypertension, causing either physiological or pathological hypertrophy.
Baum, O, Arras, M, Born, W, Gubser, M, Jirkof, P, Jakob, P, Samillan-Soto, V, Klohs, J, Rieger, G, Brock, M, Gianella, M, Baum, Oliver, Cesarovic, N, Vogel, O, Hoppeler, H, Schuler, B, Fischer, J A, Vogel, J, Hoppeler, Hans-Heinrich, Gorr, T A, Gassmann, M   +20 more
core   +2 more sources

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

The Mechanism of Calcitonin Gene-Related Peptide–Containing Nerve Innervation

Journal of Pharmacological Sciences, 2012
Calcitonin gene-related peptide (CGRP) is a major neurotransmitter and CGRP-containing primary sensory neurons play an important role in nociception and potent vasodilation.
Narumi Hashikawa-Hobara, Naoya Hashikawa, Yoshito Zamami, Shingo Takatori, Hiromu Kawasaki   +4 more
doaj   +1 more source

Calcitonin Gene-Related Peptide in the Human Hypothalamus.

Endocrinologia Japonica, 1989
Calcitonin gene-related peptide (CGRP)-like immunoreactivity (LI) in the human hypothalamus was investigated by radioimmunoassay and by immunocytochemistry. CGRP-LI was detected from two hypothalami obtained at autopsy (2.1 and 7.0 ng/g wet tissue) by radioimmunoassay.
TAKAHASHI, KAZUHIRO, MOURI, TORAICHI, SONE, MASAHIKO, MURAKAMI, OSAMU, ITOI, KEIICHI, IMAI, YUTAKA, OHNEDA, MAKOTO, YOSHINAGA, KAORU, SASANO, NOBUAKI   +8 more
openaire   +3 more sources

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

A Possible Role for Calcitonin-Gene-Related Peptide in the Regulation of the Smooth Muscle Tone of the Bladder and Penis [PDF]

, 1990
Lue, Tom F., Francois Benard, Bosch, Ruud J. L. H., Stief, Christian Georg, Bénard, Francois, Sherif R. Aboseif, Tom F. Lue, Ruud J.L.H. Bosch, Tanagho, Emil A., Emil A. Tanagho, Christian G. Stief, Aboseif, Sherif R.   +11 more
core   +2 more sources

Amylin analogues as a novel perspective in anti‐obesity therapy

British Journal of Pharmacology, EarlyView.
Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley   +1 more source