Results 81 to 90 of about 36,287 (271)

Isolation and partial characterization of the calcitonin gene in a lower vertebrate Predicted structure of avian calcitonin gene-related peptide

, 1986
The gene coding for calcitonin was isolated and characterized in a non-mammalian vertebrate, chicken. Sequencing of the 3'-end of this gene revealed after the calcitonin coding exon, an intron followed by an exon coding for a calcitonin gene-related ...
S. Minvielle, G. Milhaud, F. Lasmoles, M. Cressent, Milhaud, G., Minvielle, S., Jullienne, A., Cressent, M., Moukhtar, M.S., Lasmoles, F., A. Jullienne, M.S. Moukhtar   +11 more
core   +1 more source

Divergent Paths: A Comprehensive Review of Mechanisms and Clinical Implications in Atopic Dermatitis and Psoriasis

Allergy, EarlyView.
ABSTRACT Atopic dermatitis and psoriasis are two common cutaneous chronic inflammatory diseases. Although they share similar immunological mechanisms, their clinical implications in the patient are different. This review compares both diseases from different points of view such as genetics, natural history, triggers of disease, and skin barrier defects
Tali Czarnowicki, Kazunari Sugita, Zenas Yiu, Sandra Díez‐Ribas, Irene Garcia‐Jimenez, Emma Guttman‐Yassky, Luis F. Santamaria‐Babí   +6 more
wiley   +1 more source

New CGRP Antagonists

The Scientific World Journal, 2001
The presentation will focus on BIBN 4096 BS, since this compound is still the only potent calcitonin gene-related peptide (CGRP)-antagonist described so far[1].
H. N. Doods, M. Schindler
doaj   +1 more source

The Mechanism of Calcitonin Gene-Related Peptide–Containing Nerve Innervation

Journal of Pharmacological Sciences, 2012
Calcitonin gene-related peptide (CGRP) is a major neurotransmitter and CGRP-containing primary sensory neurons play an important role in nociception and potent vasodilation.
Narumi Hashikawa-Hobara, Naoya Hashikawa, Yoshito Zamami, Shingo Takatori, Hiromu Kawasaki   +4 more
doaj   +1 more source

Sildenafil and calcitonin gene-related peptide dilate intradural arteries:A 3T MR angiography study in healthy volunteers

, 2019
Background: Sildenafil and calcitonin gene-related peptide are vasoactive substances that induce migraine attacks in patients. The intradural arteries are thought to be involved, but these have never been examined in vivo.
Christensen, Casper Emil, Amin, F.M., Paulson, O.B., Larsson, Henrik Bo Wiberg, Petersen, Esben Thade, Younis, S., Koning, P. de, Petersen, E.T., de Koning, Patrick, Paulson, Olaf Bjarne, Larsson, H.B.W., Ashina, M., Ashina, Messoud, Amin, Faisal Mohammad, Lindberg, Ulrich, Lindberg, U., Younis, Samaira, Christensen, C.E.   +17 more
core   +1 more source

Aniridia‐associated keratopathy: Clinical and molecular mechanisms of disease progression and emerging therapeutic targets

Acta Ophthalmologica, EarlyView.
Abstract Congenital aniridia is a rare genetic disorder primarily caused by pathogenic variants of the PAX6 gene. It leads to various panocular anomalies, including aniridia‐associated keratopathy (AAK). This review highlights recent insights into its pathogenesis, focusing on clinical staging, microstructural changes in the cornea and molecular ...
N. Szentmáry, S. Suiwal, M. Amini, F. N. Fries, A. Náray, L. Latta, Z. Li, S. Li, S. Liu, S. L. Hsu, S. Kundu, G. Tóth, S. Trusen, J. Zimmermann, B. Seitz, B. Käsmann‐Kellner, Z. Hoxha, A. Langenbucher, O. Stachs, M. Cortón‐Perez, K. Tory, A. Csorba, Z. Z. Nagy, M. C. Acosta, J. Gallar, M. Csidey, E. Maka, T. Stachon   +27 more
wiley   +1 more source

A critical appraisal of the safety of bedinvetmab (Beransa), a canine antinerve growth factor monoclonal antibody

Australian Veterinary Journal, EarlyView.
Clinical scenario Canine osteoarthritis (OA) is a degenerative joint disease and is one of the most common chronic conditions in dogs and other species. The management of OA remains a longstanding focus in veterinary medicine. Traditionally, nonsteroidal anti‐inflammatory drugs (NSAIDs) have been the first‐line treatment option for canine OA. Recently,
X Yang, P Macarthur
wiley   +1 more source

Calcitonin Gene-Related Peptide Level in Cystic Fibrosis Patients

Life
Calcitonin gene-related peptide (CGRP) has long been implicated in both the physiology and pathophysiology of the respiratory tract. The objective of our study was to determine the serum concentration of alpha CGRP (αCGRP) in cystic fibrosis (CF) that ...
Sabina Galiniak, Marek Biesiadecki, Iwona Rościszewska-Żukowska, Marta Rachel   +3 more
doaj   +1 more source

Aberrant expression of calcitonin gene-related peptide and its correlation with prognosis in severe childhood pneumonia [PDF]

Clinics
OBJECTIVES: The purpose of this study was to evaluate the relationship between the serum levels of calcitonin gene-related peptide (CGRP) and the prognosis of pediatric patients with severe pneumonia. METHODS: Children diagnosed with severe pneumonia (n=
Baoqin Tao, Lei Jiang, Liang Chen
doaj   +2 more sources

Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations

International Journal of Endocrinology, 2020
Calcitonin was discovered as a peptide hormone that was known to reduce the calcium levels in the systemic circulation. This hypocalcemic effect is produced due to multiple reasons such as inhibition of bone resorption or suppression of calcium release ...
Jingbo Xie, Jian Guo, Zaeema Kanwal, Mingzheng Wu, Xiangyang Lv, Nihal Abdalla Ibrahim, Ping Li, Manal Ali Buabeid, El-Shaimaa A. Arafa, Qingshan Sun   +9 more
doaj   +1 more source