Results 81 to 90 of about 13,600,961 (272)

Calcitonin gene-related peptide (receptor) antibodies: An exciting avenue for migraine treatment [PDF]

, 2018
Specific prophylactic migraine treatments are urgently needed because of the unmet needs of many migraine patients. Antibodies targeting calcitonin gene-related peptide (CGRP) or its receptor have recently shown efficacy in episodic and chronic migraine ...
Antoinette MaassenVanDenBrink, Arn M. J. M. van den Maagdenberg, MaassenVandenBrink, A., Maassen Van Den Brink, A. (Antoinette), Maassen van den Brink, Antoinette, Terwindt, GM, Maagdenberg, A.M.J.M. (Arn), Maagdenberg, A.M.J.M. van den, Terwindt, G.M. (Gisela), Terwindt, G.M., Gisela M. Terwindt, van den Maagdenberg, A   +11 more
core   +1 more source

The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis

Allergy, EarlyView.
ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith, Nicholas P. West, Stanley Du Preez, Hugh A. Sampson, Peter W. Hellings, David Price, Liam O'Mahony, Carina Venter, Cezmi A. Akdis, Gil Yosipovitch   +9 more
wiley   +1 more source

Activation of renal pelvic chemoreceptors in rats: role of calcitonin gene-related peptide receptors [PDF]

, 2015
Substance P and calcitonin gene-related peptide (CGRP) increase afferent renal nerve activity (ARNA). A substance P receptor antagonist but not a CGRP receptor antagonist, h-CGRP (8-37), blocks the ARNA response to renal mechanoreceptor (MRI stimulation.
Gontijo, JAR, Kopp, UC
core   +2 more sources

Evaluation of serum vascular smooth muscle tone regulators in patients with hypothyroidism and concomitant hypertension: A cross-sectional study

Babcock University Medical Journal
Objective: Hypothyroidism is known to affect cardiovascular function through multiple mechanisms, yet the role of vascular smooth muscle tone regulators in early disease remains incompletely understood.
Gulden Mohammed-Baqer, Firas Algburi
doaj   +1 more source

Role of Gubernaculum testis inervation during the process of testicular migration in human fetuses [PDF]

International Brazilian Journal of Urology
Purpose: The gubernaculum seems to be the most important anatomical structure in the testicular migration process. The objective of this paper is to review current literature regarding the role of gubernaculum testis nerves in testicular migration.
Luciano A. Favorito, Laura M. M. Favorito, Ana R. M. Morais, Francisco J. B. Sampaio   +3 more
doaj   +1 more source

Calcitonin Gene-Related Peptide in the Human Hypothalamus.

Endocrinologia Japonica, 1989
Calcitonin gene-related peptide (CGRP)-like immunoreactivity (LI) in the human hypothalamus was investigated by radioimmunoassay and by immunocytochemistry. CGRP-LI was detected from two hypothalami obtained at autopsy (2.1 and 7.0 ng/g wet tissue) by radioimmunoassay.
TAKAHASHI, KAZUHIRO, MOURI, TORAICHI, SONE, MASAHIKO, MURAKAMI, OSAMU, ITOI, KEIICHI, IMAI, YUTAKA, OHNEDA, MAKOTO, YOSHINAGA, KAORU, SASANO, NOBUAKI   +8 more
openaire   +3 more sources

The effect of calcitonin gene-related peptide on healing of intestinal anastomosis in rats with experimental obstructive jaundice

, 2009
Intestinal anastomotic healing is a complex procedure in which several mediators and cytokines play roles. Calcitonin gene-related peptide is an important neuropeptide in inflammation.
Koksal, Hande, Onuk, Erhan, TANERİ, FERİT, Sancak, Banu, LEVENTOĞLU, ÖKKEŞ SEZAİ   +4 more
core   +1 more source

Activation of peripheral NOP receptors reduces periorbital mechanical allodynia evoked by CGRP in mice

British Journal of Pharmacology, EarlyView.
Background and Purpose Migraine is a neurovascular disorder largely mediated by calcitonin gene‐related peptide (CGRP). This study explores the role of the nociceptin/orphanin FQ (N/OFQ)–N/OFQ receptor (NOP) system in CGRP‐induced periorbital mechanical allodynia (PMA) in mice.
Chiara Sturaro, Pietro Pola, Michela Argentieri, Alessia Frezza, Matilde Marini, Francesco De Logu, Valentina Albanese, Marie Soukupova, Davide Malfacini, Nurulain T. Zaveri, Romina Nassini, Dane D. Jensen, Pierangelo Geppetti, Girolamo Calò, Chiara Ruzza   +14 more
wiley   +1 more source

The Mechanism of Calcitonin Gene-Related Peptide–Containing Nerve Innervation

Journal of Pharmacological Sciences, 2012
Calcitonin gene-related peptide (CGRP) is a major neurotransmitter and CGRP-containing primary sensory neurons play an important role in nociception and potent vasodilation.
Narumi Hashikawa-Hobara, Naoya Hashikawa, Yoshito Zamami, Shingo Takatori, Hiromu Kawasaki   +4 more
doaj   +1 more source

Calcitonin gene-related peptide neurons innervating the canine digestive system

, 1992
Calcitonin gene-related peptide neurons innervating the canine digestive ...
R De Giorgio (9426050), John Furness (13070439), C Sternini (19465366)   +2 more
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