Results 101 to 110 of about 11,435,493 (279)

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Screening of potential GCMS derived antimigraine compound from the leaves of Abrus precatorius Linn to target “calcitonin gene related peptide” receptor using in silico analysis

Food Science and Human Wellness, 2019
Calcitonin receptor-like receptor (CRLR) is a human protein, that produces a calcitonin gene-related peptide receptor (CGRP) when associates with human receptor activity-modifying protein-1 (HRAMP1).
Parthasarathy V., Ajay Kumar T.V
doaj   +1 more source

Circulating Levels of Calcitonin Gene-Related Peptide in Patients with Medullary Thyroid Carcinoma [PDF]

, 1988
Summary: Calcitonin gene-related peptide, originally found in rat medullary thyroid carcinoma cells, was measured by radioimmunpassay in plasma samples with added aprotinin from 17 normal volunteers and 21 patients with medullary thyroid carcinoma.
Kawai, Yuriko, Toshio Onishi, Shigeto Morimoto, Onishi, Toshio, Shouei Kim, Morimoto, Shigeto, Yuriko Kawai, Eio Koh, Ogihara, Toshio, Toshio Ogihara, Kim, Shouei, Koh, Eio   +11 more
core   +1 more source

Targeting peroxynitrite production in a model of persistent temporomandibular disorder comorbid with migraine

British Journal of Pharmacology, EarlyView.
Background and Purpose The persistence of temporomandibular disorders (TMDs), particularly myogenous, in a person with migraine can lead to exacerbated clinical outcomes and limited response to treatment. The pro‐nociceptive reactive nitroxidative species, peroxynitrite, is involved in migraine mechanisms, but little is known of its role in this ...
Simon Akerman, Ana Belen Salinas‐Abarca, Wei Guo, Daniela Salvemini, Marcela Romero‐Reyes   +4 more
wiley   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

RETRACTED: Mancinelli et al. The Effects of Taurocholic Acid on Biliary Damage and Liver Fibrosis Are Mediated by Calcitonin-Gene-Related Peptide Signaling. Cells 2022, 11, 1591

Cells
The journal retracts the article titled “The Effects of Taurocholic Acid on Biliary Damage and Liver Fibrosis Are Mediated by Calcitonin-Gene-Related Peptide Signaling” [...]
Romina Mancinelli, Ludovica Ceci, Lindsey Kennedy, Heather Francis, Vik Meadows, Lixian Chen, Guido Carpino, Konstantina Kyritsi, Nan Wu, Tianhao Zhou, Keisaku Sato, Luigi Pannarale, Shannon Glaser, Sanjukta Chakraborty, Gianfranco Alpini, Eugenio Gaudio, Paolo Onori, Antonio Franchitto   +17 more
doaj   +1 more source

Calcitonin gene-related peptide concentration in cerebrospinal fluid and serum in horses affected by trigeminal-mediated headshaking. [PDF]

Equine Vet J
Abstract Background Trigeminal‐mediated headshaking (TMHS) in horses shares clinical features with human trigeminal neuralgia (HTN). Increased levels of the neuropeptide calcitonin gene‐related peptide (CGRP) have been found in the blood and cerebrospinal fluid (CSF) of HTN patients. Inhibition of CGRP in humans has shown promise for pain relief.
Weber LA, Oltmanns H, Chiavaccini L, Pickles KJ, Roberts V, Kloock T, Niebuhr T, Feige K.   +7 more
europepmc   +2 more sources

Increase and regulation of synovial calcitonin gene-related peptide expression in patients with painful knee osteoarthritis

, 2017
Shotaro Takano*, Kentaro Uchida*, Gen Inoue, Atsushi Minatani, Masayuki Miyagi, Jun Aikawa, Dai Iwase, Kenji Onuma, Manabu Mukai, Masashi Takaso Department of Orthopedic Surgery, Kitasato University School of Medicine, Sagamihara, Japan *These authors ...
Onuma K, Mukai M, Takano S, Miyagi M, Minatani A, Uchida K, Aikawa J, Iwase D, Takaso M, Inoue G   +9 more
core  

Effects of 6‐OHDA‐Mediated Chemical Denervation of Sympathetic Axons in Inguinal Subcutaneous White Adipose Tissue

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims White adipose tissue (WAT) innervation by sensory and sympathetic axons contributes to tissue functions, but the consequences of selectively disrupting sympathetic input to WAT remain incompletely defined. Materials and Methods We utilised 6‐hydroxydopamine (6‐OHDA) as a validated approach to achieve bilateral sympathetic denervation of ...
Gilian Gunsch, Gargi Mishra, Magdalena Blaszkiewicz, Erica de Sousa, Jake W. Willows, Katharine W. Alltop, Annemarie Towle, Shawn Collins, Andre Khalil, Isabel F. Snodgrass, Lara Agha, Kiran Prakash, Rashmika Maganuru, Sugasini Dhavamani, John W. Newman, Kristy L. Townsend   +15 more
wiley   +1 more source

Sildenafil and calcitonin gene-related peptide dilate intradural arteries:A 3T MR angiography study in healthy volunteers

, 2019
Background: Sildenafil and calcitonin gene-related peptide are vasoactive substances that induce migraine attacks in patients. The intradural arteries are thought to be involved, but these have never been examined in vivo.
Christensen, Casper Emil, Amin, F.M., Paulson, O.B., Larsson, Henrik Bo Wiberg, Petersen, Esben Thade, Younis, S., Koning, P. de, Petersen, E.T., de Koning, Patrick, Paulson, Olaf Bjarne, Larsson, H.B.W., Ashina, M., Ashina, Messoud, Amin, Faisal Mohammad, Lindberg, Ulrich, Lindberg, U., Younis, Samaira, Christensen, C.E.   +17 more
core   +1 more source