Results 101 to 110 of about 36,287 (271)
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose CGRP is a potent, clinically relevant coronary vasodilator known to play a role in cardioprotection. Here, we investigated the precise intracellular signalling pathways leading to vasodilation in small coronary arteries.
Lucy A. Donovan +4 more
wiley +1 more source
Food Science and Human Wellness, 2019 Calcitonin receptor-like receptor (CRLR) is a human protein, that produces a calcitonin gene-related peptide receptor (CGRP) when associates with human receptor activity-modifying protein-1 (HRAMP1).
Parthasarathy V., Ajay Kumar T.V
doaj +1 more source
, 2017 Background Calcitonin gene-related peptide provokes migraine attacks in 65% of patients with migraine without aura. Whether aggregation of migraine in first-degree relatives (family load) or a high number of risk-conferring single nucleotide ...
Christensen, Anne Francke +5 more
core +1 more source
British Journal of Pharmacology, EarlyView.The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley +1 more source
[Calcitonin gene related peptide].
Postepy higieny i medycyny doswiadczalnej, 1996 Paper presents a recent review on the function and practical importance of CGRP in both physiology and pathology of animals and humans. The special attention was paid on CGRP role in cardiovascular, endocrine and gastrointestinal systems and in neoplasms.
Z, Zdrojewicz +4 more
openaire +1 more source
British Journal of Pharmacology, EarlyView.Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley +1 more source
Effectiveness and acceptability of oral migraine preventives: A prospective, observational study
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Objective To explore the adherence, effectiveness, safety, tolerability, and acceptability of frequently used oral migraine preventive drugs in a real‐world setting. Background Oral migraine preventives are previously mainly explored in randomized controlled trials, whereas real‐world data on treatment outcomes remain limited. Methods MigriNor
Hedda S. Riise +13 more
wiley +1 more source
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Objective This study aimed to evaluate demographic characteristics, treatment effectiveness, and safety outcomes in patients with migraine undergoing anti‐calcitonin gene‐related peptide (CGRP) treatments regarding the presence of autoimmune diseases. Background CGRP has an important role in migraine pathophysiology through neuronal modulation
María Clara García‐Castillo +37 more
wiley +1 more source
, 1989 Origins and pathways of cerebrovascular substance P- and calcitonin gene-related peptide-positive nerves in rat were studied by immunohistochemistry combined with denervation experiments and retrograde axonal tracer technique.
Suzuki, N +2 more
core +2 more sources
Headache: The Journal of Head and Face Pain, EarlyView.Sleep restriction (SR) and caffeine intake act as environmental modulators of migraine susceptibility. Their effects are sex‐dependent: Females show heightened sensitivity under both SR and caffeine conditions. Males require the combination of SR and caffeine to exhibit susceptibility.
Gabriel Camargo de Oliveira +7 more
wiley +1 more source