Results 101 to 110 of about 13,600,961 (272)

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Demographic and Characteristics of Primary Headache in Egyptian Epileptic Patients [PDF]

Zagazig University Medical Journal
Background: Migraine pathophysiology has been linked to neuroinflammation. During a migraine attack, trigeminal activation results in the release of calcitonin gene-related peptide (CGRP), which stimulates the release of inflammatory cytokines and plays ...
Amal Elmotayam, Hanan Mohammed, Marwan Saleh, Abdelrahman Fahmy   +3 more
doaj   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

Functional connectivity in patients with Migraine after preventive treatment with calcitonin gene-related peptide receptor antagonists

, 2022
The aim of the project is to determine longitudinal resting-state functional connectivity (rsFC) changes in patients with migraine undergoing preventive treatment with calcitonin gene-related peptide receptor antagonists in comparison to baseline rsFC in
Sebastian Strauß, Martin Domin, Martin Lotze, Frederik Behr, Robert Fleischmann, Pavel Hok   +5 more
core   +1 more source

GLP‐1 receptor activation attenuates chronic migraine‐like behaviour: Sex‐specific modulation of opioid‐ and endocannabinoid‐related pathways

British Journal of Pharmacology, EarlyView.
Background and Purpose Chronic migraine (CM) is a highly disabling condition that remains suboptimally treated. Metabolic disturbances may trigger migraine chronification, whereas impaired endogenous pain inhibition contributes to CM development. Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), used for type 2 diabetes and obesity, show efficacy ...
Katarina Sićović, Katarina Nastić, Miroslav Dinić, Emilija Brdarić, Uroš Pecikoza, Maja Tomić, Ana Micov   +6 more
wiley   +1 more source

Amylin Receptor Signalling in the Laterodorsal Tegmental Nucleus Controls Food Intake Through Projections to the Ventral Tegmental Area

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background The role of amylin signalling in energy balance control has been understudied in calcitonin receptor (CTR) expressing nuclei such as the mesopontine laterodorsal tegmental nucleus (LDTg). Our lab has shown that LDTg amylin signalling reduces feeding and body weight, but the neuronal phenotype and downstream targets of LDTgCTR cells ...
Marcos J. Sanchez Navarro, Carlie Zhang, Samantha M. Fortin, Matthew R. Hayes   +3 more
wiley   +1 more source

[Calcitonin gene related peptide].

Postepy higieny i medycyny doswiadczalnej, 1996
Paper presents a recent review on the function and practical importance of CGRP in both physiology and pathology of animals and humans. The special attention was paid on CGRP role in cardiovascular, endocrine and gastrointestinal systems and in neoplasms.
Z, Zdrojewicz, M, Bolanowski, G, Drumlak, M, Zabel, A, Januszewski   +4 more
openaire   +1 more source

Plasma amylin levels in migraine and after erenumab treatment: A REFORM study

Headache: The Journal of Head and Face Pain, EarlyView.
Plain Language Summary Researchers are searching for blood tests that can show what is happening in migraine and help predict who will benefit from preventive treatment, and blood amylin (a signaling molecule known to trigger migraine) has been shown to be elevated in people with chronic migraine.
Rogelio Domínguez‐Moreno, Tyla I. Alexander, William K. Karlsson, Haidar M. Al‐Khazali, Michael L. Garelja, Rune H. Christensen, Messoud Ashina, Debbie L. Hay, Håkan Ashina   +8 more
wiley   +1 more source

Origins and pathways of cerebrovascular nerves storing substance P and calcitonin gene-related peptide in rat

, 1989
Origins and pathways of cerebrovascular substance P- and calcitonin gene-related peptide-positive nerves in rat were studied by immunohistochemistry combined with denervation experiments and retrograde axonal tracer technique.
Suzuki, N, Owman, Christer, Hardebo, Jan Erik, Owman, Christer,, Hardebo, Jan Erik,, Lund University.   +5 more
core   +2 more sources

Calcitonin Gene-Related Peptide and Size of the Atrial Septal Defect in New-Onset Migraine After Transcatheter Closure: Results of a Preliminary Study

, 2014
Background.-New-onset migraine headache attacks (MHAs) can occur after atrial septal device implantation in patients without previous migraine. Plasma calcitonin gene-related peptide (CGRP), which plays a crucial role in migraine pathophysiology, has ...
Wei, Shu-Hao;Fan, Pi-Chuan;Kuo, Ping-Hung;Chiou, Lih-Chu;Wang, Jou-Kou, 范碧娟 ;王主科 ;郭炳宏 ;邱麗珠   +1 more
core   +1 more source