Results 121 to 130 of about 13,600,961 (272)

Real-World Clinical Effectiveness and Migraine-Related Healthcare Resource Utilization in Patients Initiating Fremanezumab in Germany and the United Kingdom

Therapeutics and Clinical Risk Management
Axel Heinze,1 Shazia K Afridi,2 Todor I Totev,3 Lynda J Krasenbaum,4 Emi Terasawa,5 Hasan Akcicek,6 Joachim Hipp,7 Dalbir Dhiraj,8 Rochelle Sun,3 Erica Yim,5 Binyam Yilma,5 Maurice T Driessen9 1Migraine and Headache Center, Pain Clinic Kiel, Kiel ...
Heinze A, Afridi SK, Totev TI, Krasenbaum LJ, Terasawa E, Akcicek H, Hipp J, Dhiraj D, Sun R, Yim E, Yilma B, Driessen MT   +11 more
doaj  

Calcitonin gene-related peptide antagonism and cluster headache: an emerging new treatment

, 2017
Calcitonin gene-related peptide (CGRP) is a key signaling molecule involved in migraine pathophysiology. Efficacy of CGRP monoclonal antibodies and antagonists in migraine treatment has fueled an increasing interest in the prospect of treating cluster ...
Lawrence Newman, Ashina, Håkan, Sait Ashina, Håkan Ashina, Ashina, Sait, Newman, Lawrence   +5 more
core   +1 more source

Beyond headache frequency: How acute treatment response shapes migraine‐related disability—Insights from a joint stratification framework: A cross‐sectional study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background The aim of this study was to examine whether joint profiling of headache frequency and acute treatment response identifies clinically meaningful patient subgroups with different disability burden and treatment needs, and whether per‐attack acute treatment response provides disability‐relevant information beyond monthly ...
Xiaonuo Xu, Hui Li, Xin Liang, Xiaoping Fan, Ge Tan, Xiangmin Yu, Xin Li, Liang Dong, Jiying Zhou   +8 more
wiley   +1 more source

Critical comparison of ELISA kits for CGRP measurements in migraine

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background Our aim was to compare the performance of commercially available enzyme‐linked immunosorbent assay (ELISA) kits for detecting mature α‐ and β‐calcitonin gene‐related peptide (CGRP) isoforms and test the hypothesis of a potential lack of reliability.
Lucía de la Guerra‐Sasián, Vicente González‐Quintanilla, Jorge Madera, Sara Pérez‐Pereda, Julio Pascual, María Muñoz‐San Martín   +5 more
wiley   +1 more source

Real‐world diagnosis and treatment of individuals with migraine in the United States: The Migraine Insights in Diagnosis and Treatment (MIND) study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective The objective of this study was to describe the real‐world diagnosis and treatment patterns of individuals newly diagnosed with migraine in the United States (US). Background Over 10% of adults in the US are living with migraine.
Fred Cohen, Vincent Martin, Avani Patel, Shelby L. Corman, Katie B. Tellor, Meghan Fajardo, D. Cortney Hayflinger, Simon Dagenais   +7 more
wiley   +1 more source

Post‐traumatic headache: A two‐arm parallel‐group, randomized, single‐blind, sham‐controlled clinical superiority trial evaluating repetitive transcranial magnetic stimulation as a novel treatment modality

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective This study aimed to evaluate the effect of repetitive transcranial magnetic stimulation (rTMS) on persistent post‐traumatic headache (pPTH) in adults with pPTH and a high burden of persistent post‐concussion symptoms (pPCS) 4–5 months after mild traumatic brain injury (mTBI).
Charlotte Nygaard, Simple F. Kothari, Henrik W. Schytz, Lene Odgaard, Carsten B. Pedersen, Toril Skandsen, Anne Sofie M. Lauridsen, Amalie B. Nicolaisen, Mille M. Thastum, Henriette H. Stabel, Camilla B. Lundquist, Line Amalie Hellemose, Sedsel K. S. Pedersen, Jørgen Feldbæk Nielsen   +13 more
wiley   +1 more source

Expression of calcitonin gene-related peptide and pulp sensitivity tests in irreversible pulpitis

Brazilian Oral Research
The aim of the present study was to identify the relationship between the expression of calcitonin gene-related peptide (CGRP) and the responses of pulp sensitivity tests in healthy pulps and irreversible pulps by performing a cross-sectional study on ...
Brenda Eréndida CASTILLO-SILVA, Verónica MARTÍNEZ-JIMÉNEZ, Gabriel Alejandro MARTÍNEZ- CASTAÑÓN, Carlo Eduardo MEDINA-SOLÍS, Eva Concepción AGUIRRE-LÓPEZ, Jesús Ramón CASTILLO-HERNÁNDEZ, Nereyda NIÑO-MARTÍNEZ, Nuria PATIÑO-MARÍN   +7 more
doaj   +1 more source

The harnessing potential of carboxymethyl beta glucan: A driver of skin repair

International Journal of Cosmetic Science, EarlyView.
Carboxymethyl Beta‐Glucan (CM‐BG) drives skin repair through multifaceted actions, notably in wounded 3D models. It activates Dectin‐1 and mitigates inflammation (reducing pro‐inflammatory mediators, boosting anti‐inflammatory IL‐10) in cellular models, while enhancing epidermal differentiation and collagen I synthesis by fibroblasts across cellular ...
Caroline Pichon, Xavier Marat, Alice Brule, Annie Black, Audrey Gueniche   +4 more
wiley   +1 more source

The Expression of Neuropeptides in Pulpitis: A Systematic Review and Meta‐Analysis

International Endodontic Journal, EarlyView.
ABSTRACT Background Neuropeptides play key roles in the inflammatory, nociceptive and reparative processes of the dental pulp. Their upregulation has been frequently observed in inflamed pulps, suggesting potential diagnostic value supporting a role for neurogenic inflammation in symptomatic irreversible pulpitis.
N. Watson, D. Edwards, Q. Vuong, I. Obara   +3 more
wiley   +1 more source

Safety and tolerability of atogepant for the preventive treatment of migraine: a post hoc analysis of pooled data from four clinical trials

The Journal of Headache and Pain
Background Conventional, non-specific preventive migraine treatments often demonstrate low rates of treatment persistence due to poor efficacy or tolerability.
Paul Rizzoli, Michael J. Marmura, Jennifer Robblee, Jennifer McVige, Sara Sacco, Stephanie J. Nahas, Jessica Ailani, Rosa De Abreu Ferreira, Julia Ma, Jonathan H. Smith, Brett Dabruzzo, Messoud Ashina   +11 more
doaj   +1 more source