Results 121 to 130 of about 56,119 (256)

Functional characteristics of calcitonin gene-related peptide receptors in human Ewing's sarcoma WE-68 cells [PDF]

, 1989
Calcitonin gene-related peptide (CGRP) receptor activity was studied in WE-68 human Ewing's sarcoma cells. 125I-human CGRP bound in a time-dependent, reversible and saturable manner.
Andersen, Bocharov, Brian G. Coon, Calvo, Carmeliet, Chiu, Chiu, Chiu, Cicha, Conway, Cosson, Dai, Davies, Davies, Di Stefano, Diaz-Rohrer, DiMaio, Endres, Eskens, Feaver, Fleming, Frangos, Galvagni, Gavard, Giampietro, Gimbrone, Goel, Gu, Hahn, Hahn, Hahn, Haiko, Harry, Hove, Hwang, Jennifer S. Fang, Jeon-Leon Thomas, Jin, Jinah Han, Jongstra-Bilen, Joukov, Karkkainen, Kubo, Lampugnani, Langille, Liu, Lucitti, Maciag, Madhusudhan Budatha, Manni, Martin A. Schwartz, Mattsson, Moore, Nam, Navarro, Nawroth, Nayak, Nicolas Baeyens, Nigro, Olsson, Orr, Orr, Orr, Osawa, Piedra, Pitulescu, Pohl, Privratsky, Sanguk Yun, Sharpe, Stevens, Tammela, Tedgui, Therien, Tyler D. Ross, Tzima, Vestweber, Wang, Wang, Warfel, Witmer   +80 more
core   +1 more source

Calcitonin Gene‐Related Peptide (CGRP) and Migraine [PDF]

Headache: The Journal of Head and Face Pain, 2006
The neuropeptide calcitonin gene‐related peptide (CGRP) has long been postulated to play an integral role in the pathophysiology of migraine. While clinical findings are consistent with such a role, the specific pathogenic mechanisms of CGRP in migraine have remained speculative until recently. Through advances in molecular neuroscience, the pathogenic
openaire   +2 more sources

Novel optimization of multi‐mechanistic approaches for the acute treatment of a migraine attack: A review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To highlight key factors required to optimize multi‐mechanistic approaches with oral combination treatments for the acute management of a migraine attack. Background Given the complex multi‐factorial nature of migraine, combining treatments with different mechanisms of action should improve outcomes compared to monotherapies, but ...
Stephen Silberstein, Alan M. Rapoport
wiley   +1 more source

Double labelling immunohistochemical characterization of autonomic sympathetic neurons innervating the sow retractor clitoridis muscle [PDF]

, 2008
Retrograde neuronal tracing and immunohistochemical methods were used to define the neurochemical content of sympathetic neurons projecting to the sow retractor clitoridis muscle (RCM). Differently from the other smooth muscles of genital organs, the RCM
Acone, Franca, Bo Minelli, Luisa, Botti, Maddalena, Gazza, Ferdinando, Palmieri, Giovanni, Panu, Rino, Ragionieri, Luisa   +6 more
core  

Effectiveness and acceptability of oral migraine preventives: A prospective, observational study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To explore the adherence, effectiveness, safety, tolerability, and acceptability of frequently used oral migraine preventive drugs in a real‐world setting. Background Oral migraine preventives are previously mainly explored in randomized controlled trials, whereas real‐world data on treatment outcomes remain limited. Methods MigriNor
Hedda S. Riise, Melanie R. Simpson, Ketil A. Espnes, Erling A. Tronvik, Andreas K. Husøy, Lise R. Øie, Anker Stubberud, Emil Kofoed, Aurora H. Alstad, Hedda H. Hagen, Maren G. Lien, Marie L. Stavseng, Ella R. Sæther, Tore Wergeland   +13 more
wiley   +1 more source

Microneedles for the treatment of migraine and orofacial pain: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Background Migraine is a common neurological disorder and a primary headache condition. Despite its central origin, migraine pain may be referred to the orofacial region via trigeminal pathways, resulting in phenotypic overlap with other orofacial pain (OFP) conditions.
Baicheng Cao, Qiuyi Chen, Yuhan Liu, Ruozhou Wu, Bin Li, Qing Cai, Lu Liu   +6 more
wiley   +1 more source

Improved cardiac performance with human calcitonin gene related peptide in patients with congestive heart failure [PDF]

, 2017
Study objective - The aim of the study was to assess the cardiovascular effects of human calcitonin gene related peptide (CGRP) in patients with congestive heart failure.
Agnusdei, D., Fischer, J A., Gennari, C., Nami, R.   +3 more
core  

Post‐marketing safety of CGRP monoclonal antibodies and gepants: A systematic review of spontaneous reporting system data

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective Calcitonin gene‐related peptide (CGRP) inhibitors, including monoclonal antibodies (mAbs) and small‐molecule antagonists (gepants), have transformed migraine treatment. Although clinical trials established their efficacy and initial safety, post‐marketing surveillance is essential for understanding their real‐world safety profile in ...
Martina Giacon, Salvatore Terrazzino
wiley   +1 more source

Delayed urticaria during treatment with anti‐CGRP monoclonal antibodies in migraine

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To characterize clinical presentation and management of urticaria associated with calcitonin gene‐related peptide (CGRP) ‐targeting monoclonal antibodies (mAbs) for migraine prophylaxis. Background CGRP‐targeting mAbs are effective in migraine prophylaxis, but have been associated with hypersensitivity reactions, including urticaria.
Christoph T. Berger, Federico Burguet Villena, Severin B. Vogt, Lukas Heydrich, Karin Hartmann, Athina Papadopoulou   +5 more
wiley   +1 more source

Variations in Calcitonin Gene-Related Peptide, Adiponectin, and Ghrelin Levels and Their Effects on Preeclampsia

Clinical and Experimental Obstetrics & Gynecology
Background: This study aimed to investigate serum levels of calcitonin gene-related peptide (CGRP) and explore potential associations between serum CGRP, adiponectin, and ghrelin concentrations in patients with preeclampsia.
Özlem Koşar Can, Umit Cabus, Cihan Kabukcu, Semin Fenkci, Veysel Fenkci, Yasar Enli   +5 more
doaj   +1 more source