Results 201 to 210 of about 97,221 (328)

Vildagliptin and Omarigliptin Differentially Bind to DPP‐4 Homodimers and Modulate Osteoclast‐Mediated Bone Resorption

open access: yesComprehensive Physiology, Volume 16, Issue 1, February 2026.
Vildagliptin and omarigliptin, dipeptidyl peptidase‐4 (DPP‐4) inhibitors, have differential effects on bone cells. Although vildagliptin improved the bone microstructure of high‐fat diet‐fed rats, it was unable to downregulate osteoclastogenesis or the expression of key osteoclast transcripts.
Ratchaneevan Aeimlapa   +11 more
wiley   +1 more source

Gut microbiota and central nervous system's direct bidirectional regulation: The mechanisms of the gut–brain axis in irritable bowel syndrome

open access: yesClinical and Translational Discovery, Volume 6, Issue 1, February 2026.
Gut microbiota directly modulates central nervous system activity via vagal, sympathetic and sensory neural circuits. Brainstem nuclei integrate microbial signals to regulate gut motility, secretion and visceral sensitivity. DRG neurons and stress‐responsive pathways link microbial cues to host defence and epithelial homeostasis. Dysregulated gut–brain
Jinxia Zhai   +3 more
wiley   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo   +11 more
wiley   +1 more source

Calcitonin gene-related peptide monoclonal antibody treatment for new daily persistent headache. [PDF]

open access: yesJ Headache Pain
Cheema S   +5 more
europepmc   +1 more source

Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies

open access: yesMedComm, Volume 7, Issue 2, February 2026.
The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu   +6 more
wiley   +1 more source

Population Pharmacokinetic Modeling of the Oral Calcitonin Gene-Related Peptide Receptor Antagonist Rimegepant in Adults. [PDF]

open access: yesCPT Pharmacometrics Syst Pharmacol
Comisar CM   +9 more
europepmc   +1 more source

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