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Calcitonin gene-related peptide and hypertension
Peptides, 2005Capsaicin-sensitive sensory nerves participate in the regulation of cardiovascular functions both in the normal state and the pathophysiology of hypertension through the actions of potent vasodilator neuropeptides, including calcitonin gene-related peptide (CGRP).
Pan-Yue, Deng, Yuan-Jian, Li
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Calcitonin gene-related peptide and migraine
Current Opinion in Neurology, 2015Migraine is a common, complex disorder of the brain with significant morbidity. As the pathophysiology of the disorder has become better appreciated, the role of neuropeptides has been explored. Calcitonin gene-related peptide (CGRP) has emerged as a promising therapeutic target.CGRP is widely distributed in the nervous system, particularly at ...
Karsan, Nazia, Goadsby, Peter J.
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Calcitonin gene-related peptide and the kidney
Current Opinion in Nephrology and Hypertension, 1994Calcitonin gene-related peptide (CGRP) is a recently discovered neurotransmitter that is extensively localized in fibers innervating vascular and endocrine systems. CGRP possesses potent vasorelaxant effects, and a role for this peptide in the regional regulation of blood flow has been suggested. Although pharmacologic evidence indicates that the renal
D, Villarreal, G, Reams, R, Freeman
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Calcitonin and calcitonin gene-related peptide in the human prostate gland
The Prostate, 2000Calcitonin-related peptides have been found in the human prostate, and calcitonin (CT) and calcitonin gene-related peptide (CGRP) have been demonstrated in subpopulations of neuroendocrine (NE) cells. The purpose of this study was to determine the concentrations of CT and CGRP as well as the densities of NE cells in normal prostates, benign prostatic ...
P A, Abrahamsson +5 more
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Changes of Plasma Calcitonin Gene–Related Peptide Levels in Postmenopausal Women
American Journal of Obstetrics and Gynecology, 1996 OBJECTIVE: Our purpose was to investigate whether the secretion of a cardiovascular hormone, calcitonin gene-related peptide, is modified in climateric women according to cardiovascular adaptive responses.
Felice Petraglia +2 more
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Calcitonin and Calcitonin Gene-Related Peptide
1989The Ca++ ion plays a critical role in neuronal transmission. Therefore, agents capable of modulating it can exert profound effects on the cell’s ability to interpret extracellular signals. In 1964, Hano et al.1 reported that intracisternal Ca++ administration antagonized the action of morphine, which, conversely, was potentiated by the Ca++ chelator ...
Sandra P. Welch, William L. Dewey
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Amylin, Calcitonin Gene-Related Peptide, Calcitonin, and Adrenomedullin: A Peptide Superfamily
Critical Reviews™ in Neurobiology, 1997The calcitonin gene peptide superfamily consists of calcitonin (CT), calcitonin gene-related peptide (CGRP), and amylin. CT and CGRP derive from the CT/CGRP gene, which is encoded on chromosome 11. Alternative splicing of the primary RNA transcript leads to the translation of CGRP and CT peptides in a tissue-specific manner.
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Menopausal Flushes and Calcitonin-Gene-Related Peptide
Lancet, The, 1993Masataka Shiraki +2 more
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Molecular and Cellular Endocrinology, 2003
In this study, we describe the cloning and tissue expression of equine calcitonin (CT), calcitonin-gene related peptide (CGRP)-I, and CGRP-II cDNA. We also describe a novel divergent form of CGRP (CGRP-I). Equine CT has greatest homology (>85%) to human, rat and mouse subgroups of calcitonins.
Ramiro E, Toribio +4 more
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In this study, we describe the cloning and tissue expression of equine calcitonin (CT), calcitonin-gene related peptide (CGRP)-I, and CGRP-II cDNA. We also describe a novel divergent form of CGRP (CGRP-I). Equine CT has greatest homology (>85%) to human, rat and mouse subgroups of calcitonins.
Ramiro E, Toribio +4 more
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Stimulation of calcitonin secretion in the pig by calcitonin gene-related peptide
Bone and Mineral, 1991Pig thyroid glands were surgically isolated in situ and perfused with autologous blood to which was added known concentrations of calcitonin gene-related peptide (alpha CGRP). When thyroids were perfused with measured concentrations of CGRP within the range of 0.6-600 nM, the secretion rate of calcitonin (CT) was stimulated while the release of T3, T4,
C W, Cooper +6 more
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