Pain Research and Management, 2021 Voluntary exercise is sufficient to protect against neuropathic pain. However, it is unclear whether voluntary exercise reduces immobilization-induced hyperalgesia. We examined the effect of voluntary forelimb exercise on immobilized-induced hyperalgesia
Kumiko Ishikawa +7 more
doaj +1 more source
New players in the preventive treatment of migraine. [PDF]
, 2015 Migraine is a common, chronic disorder of the brain causing much disability, as well as personal, familial and societal impact. Several oral preventive agents are available in different countries for the prevention of migraine, but none have performed ...
Mitsikostas, Dimos D, Rapoport, Alan M
core +3 more sources
Nociceptive neuropeptide increases and periorbital allodynia in a model of traumatic brain injury. [PDF]
, 2012 OBJECTIVE: This study tests the hypothesis that injury to the somatosensory cortex is associated with periorbital allodynia and increases in nociceptive neuropeptides in the brainstem in a mouse model of controlled cortical impact (CCI) injury.
Amenta, Peter S. +4 more
core +2 more sources
Lasmiditan inhibits calcitonin gene-related peptide release in the rodent trigeminovascular system
Pain, 2020 Lasmiditan, an antimigraine drug with selective 5-HT1F receptor affinity, prejunctionally inhibits calcitonin gene-related peptide release in peripheral and central trigeminal nerve terminals of rodents.
Alejandro Labastida-Ramírez +8 more
semanticscholar +1 more source
Calcitonin gene-related peptide is potential therapeutic target of osteoporosis
Heliyon, 2022 Osteoporosis is a skeletal disorder characterised by the decrease of bone mineral density and is becoming prevalent with the entry of an ageing era.
Hua Wu, Xue-qin Lin, Yu Long, Jing Wang
doaj +1 more source
Functional characteristics of calcitonin gene-related peptide receptors in human Ewing's sarcoma WE-68 cells [PDF]
, 1989 Calcitonin gene-related peptide (CGRP) receptor activity was studied in WE-68 human Ewing's sarcoma cells. 125I-human CGRP bound in a time-dependent, reversible and saturable manner.
Andersen +80 more
core +1 more source
Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B [PDF]
, 2015 Voltage-gated potassium channels (Kv) are important regulators of membrane potential in vascular smooth muscle cells, which is integral to controlling intracellular Ca2+ concentration and regulating vascular tone. Previous work indicates that Kv channels
A Adebiyi +64 more
core +5 more sources
Effects of Calcitonin-Gene-Related-Peptide on Auditory Nerve Activity
Frontiers in Cell and Developmental Biology, 2021 Calcitonin-gene-related peptide (CGRP) is a lateral olivocochlear (LOC) efferent neurotransmitter. Depression of sound-driven auditory brainstem response amplitude in CGRP-null mice suggests the potential for endogenous CGRP release to upregulate ...
Colleen G. Le Prell +4 more
doaj +1 more source
Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin [PDF]
Biochemical Journal, 1991 Near-u.v. and far-u.v. c.d. spectra of human alpha-calcitonin-gene-related peptide (h alpha CGRP), analogues and fragments of CGRP and amylin were recorded in aqueous solution and in trifluoroethanol (TFE)/water mixtures. All peptides contained significant amounts of alpha-helix in aqueous solution, and this amount increased on adding TFE.
J A, Hubbard +5 more
openaire +2 more sources
DINeR: Database for Insect Neuropeptide Research [PDF]
, 2017 Neuropeptides are responsible for regulating a variety of functions, including development, metabolism, water and ion homeostasis, and as neuromodulators in circuits of the central nervous system.
Davies, Shireen-Anne +5 more
core +1 more source