Results 1 to 10 of about 39,277 (265)

Structural Determinants in the Calcitonin Receptor-Like Receptor (Crlr) Important for Cgrp and Adrenomedullin (Am) Receptor Function of Crlr/Receptor-Activity-Modifying Protein (Ramp) 1 and Crlr/Ramp2 Heterodimers [PDF]

The Scientific World Journal, 2001
Cell surface protein cross-linking, coimmmunoprecipitation, and confocal microscopy identified CRLR/RAMP1-, CRLR/RAMP2-, and calcitonin receptor isotype 2 (CTR2)/RAMP1 heterodimers as CGRP-, AM-, and CGRP/amylin receptors, linked to cAMP production ...
W. Born, K. Leuthauser, R. Gujer, R. Muff, J.A. Fischer   +4 more
doaj   +5 more sources

Caveolin-1 negatively regulates the calcitonin receptor-like receptor and neuroinflammation in a female mouse model of migraine [PDF]

Journal of Neuroinflammation
Background Caveolin-1 (CAV1), a scaffolding protein critical for caveolae formation, regulates G-protein-coupled receptor (GPCR) signaling via caveolae-mediated endocytosis.
Yanjie Zhou, Wu Chen, Yu Zhang, Liu Yang, Fu Lu, Wen Yan, Qingfang Xie, Ying Huang, Wanbin Huang, Lintao Wang, Ziming Zeng, Zheman Xiao   +11 more
doaj   +2 more sources

Exploring the epigenetic modifications of the RONS-TRPA1-CGRP axis in migraine pathophysiology [PDF]

The Journal of Headache and Pain
Background Epigenetic studies in migraine provided results on the occurrence or lack of epigenetic modifications of genes whose products are important in migraine pathogenesis. However, these studies focus on single genes without analyzing how epigenetic
Michal Fila, Elzbieta Pawlowska, Jan Krekora, Maria Mitus-Kenig, Janusz Blasiak   +4 more
doaj   +2 more sources

CGRP and the Calcitonin Receptor are Co-Expressed in Mouse, Rat and Human Trigeminal Ganglia Neurons

Frontiers in Physiology, 2022
The neuropeptide calcitonin gene-related peptide (CGRP) is expressed in the trigeminal ganglia, a key site in craniofacial pain and migraine. CGRP potently activates two receptors: the CGRP receptor and the AMY1 receptor. These receptors are heterodimers
Tayla A. Rees, Tayla A. Rees, Andrew F. Russo, Simon J. O’Carroll, Debbie L. Hay, Debbie L. Hay, Christopher S. Walker, Christopher S. Walker   +7 more
doaj   +1 more source

Multi-biological functions of intermedin in diseases

Frontiers in Physiology, 2023
Intermedin (IMD) is a member of the calcitonin gene-related peptide (CGRP)/calcitonin (CT) superfamily, and it is expressed extensively throughout the body.
Zhi Yang, Zhi Yang, Hongchun Li, Pengfei Wu, Qingyan Li, ChunYan Yu, Denian Wang, Denian Wang, Weimin Li, Weimin Li   +9 more
doaj   +1 more source

Intermedin Is a Calcitonin/Calcitonin Gene-related Peptide Family Peptide Acting through the Calcitonin Receptor-like Receptor/Receptor Activity-modifying Protein Receptor Complexes [PDF]

Journal of Biological Chemistry, 2004
Calcitonin, calcitonin gene-related peptide (CGRP), adrenomedullin (ADM), and amylin belong to a unique group of peptide hormones important for homeostasis in diverse tissues. Calcitonin is essential for calcium balance, whereas CGRP and ADM are important for neurotransmission and cardiovascular and respiratory regulation.
Jaesook, Roh, Chia Lin, Chang, Alka, Bhalla, Cynthia, Klein, Sheau Yu Teddy, Hsu   +4 more
openaire   +2 more sources

Post-endocytic Sorting of Calcitonin Receptor-like Receptor and Receptor Activity-modifying Protein 1 [PDF]

Journal of Biological Chemistry, 2007
Calcitonin receptor-like receptor (CLR) and the receptor activity-modifying protein 1 (RAMP1) comprise a receptor for calcitonin gene-related peptide (CGRP). Although CGRP induces endocytosis of CLR/RAMP1, little is known about post-endocytic sorting of these proteins.
Graeme S, Cottrell, Benjamin, Padilla, Stella, Pikios, Dirk, Roosterman, Martin, Steinhoff, Eileen F, Grady, Nigel W, Bunnett   +6 more
openaire   +2 more sources

Effect of Xiongmatang Extract on Behavioral and TRPV1-CGRP/CGRP-R Pathway in Rats With Migraine

Frontiers in Pharmacology, 2022
Migraine is a complex neurovascular disease, which seriously affects the quality of life in patients. This study aimed to evaluate the effect of Xiongmatang (XMT) extract on rats with migraine induced by inflammatory soup and the underlying mechanisms ...
Dingding Liu, Lulu Chang, Jingru Wang, Qiang Zhu, Ning Jiang, Mudassar Azhar, Ayaz Ahmed, Guirong Zeng   +7 more
doaj   +1 more source

Gα_s-Coupled CGRP Receptor Signaling Axis from the Trigeminal Ganglion Neuron to Odontoblast Negatively Regulates Dentin Mineralization

Biomolecules, 2022
An inflammatory response following dental pulp injury and/or infection often leads to neurogenic inflammation via the axon reflex. However, the detailed mechanism underlying the occurrence of the axon reflex in the dental pulp remains unclear.
Natsuki Saito, Maki Kimura, Takehito Ouchi, Tatsuya Ichinohe, Yoshiyuki Shibukawa   +4 more
doaj   +1 more source

Receptor activity‐modifying protein‐dependent effects of mutations in the calcitonin receptor‐like receptor: implications for adrenomedullin and calcitonin gene‐related peptide pharmacology [PDF]

British Journal of Pharmacology, 2014
Background and PurposeReceptor activity‐modifying proteins (RAMPs) define the pharmacology of the calcitonin receptor‐like receptor (CLR). The interactions of the different RAMPs with this class B GPCR yield high‐affinity calcitonin gene‐related peptide (CGRP) or adrenomedullin (AM) receptors.
Watkins, H.A., Walker, C.S., Ly, K.N., Bailey, R.J., Barwell, J., Poyner, D.R., Hay, D.L.   +6 more
openaire   +2 more sources