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Amylin Receptor 1 Mutagenesis Revealed a Potential Role of Calcitonin Serine 29 in Receptor Interaction [PDF]
BiomedicinesBackground: The amylin receptor is a receptor for the peptide hormone amylin, and its activation is known to reduce body weight. The amylin receptor functions as a heterodimer complex that consists of the calcitonin receptor for peptide hormone ...
Hyeseon Song +5 more
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Tumour calcitonin. Interaction with specific calcitonin receptors [PDF]
Biochemical Journal, 1980 The human epidermoid bronchial carcinoma (BEN) cell line has been shown to have specific membrane binding sites for calcitonin and to secrete high-molecular-weight forms (ranging from 40000 to 10000) of immunoreactive calcitonin. Synthetic salmon and human calcitonins and a thyroid extract of porcine calcitonin have been shown to displace 125I-labelled
J, Ham, M L, Ellison, J, Lumsden
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Activation of Calcitonin Receptor and Calcitonin Receptor-like Receptor by Membrane-anchored Ligands [PDF]
Journal of Biological Chemistry, 2010 G protein-coupled receptors (GPCRs) are the most important pharmaceutical targets, and more than 40% of drugs in use today modulate GPCR signaling. A major hurdle in the development of therapies targeting GPCRs is the drug candidate's nonselective actions in multiple tissues.
Chia Lin, Chang +2 more
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Multi-biological functions of intermedin in diseases
Frontiers in Physiology, 2023 Intermedin (IMD) is a member of the calcitonin gene-related peptide (CGRP)/calcitonin (CT) superfamily, and it is expressed extensively throughout the body.
Zhi Yang +9 more
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Amylin and Calcitonin: Potential Therapeutic Strategies to Reduce Body Weight and Liver Fat
Frontiers in Endocrinology, 2021 The hormones amylin and calcitonin interact with receptors within the same family to exert their effects on the human organism. Calcitonin, derived from thyroid C cells, is known for its inhibitory effect on osteoclasts.
David S. Mathiesen +10 more
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Biomolecules, 2021 The calcitonin and amylin receptors (CTR and AMY receptors) are the drug targets for osteoporosis and diabetes treatment, respectively. Salmon calcitonin (sCT) and pramlintide were developed as peptide drugs that activate these receptors.
Sangmin Lee
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Exploring Ligand Binding to Calcitonin Gene-Related Peptide Receptors
Frontiers in Molecular Biosciences, 2021 Class B1 G protein-coupled receptors (GPCRs) are important targets for many diseases, including cancer, diabetes, and heart disease. All the approved drugs for this receptor family are peptides that mimic the endogenous activating hormones.
Giuseppe Deganutti +7 more
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Frontiers in Endocrinology, 2022 Knockout technologies provide insights into physiological roles of genes. Studies initiated into endocrinology of heteromeric G protein-coupled receptors included deletion of receptor activity modifying protein-3, an accessory protein that alters ligand ...
Suruchi Pacharne +6 more
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Calcitonin and calcitonin receptor‐like receptors: common themes with family B GPCRs? [PDF]
British Journal of Pharmacology, 2012 The calcitonin receptor (CTR) and calcitonin receptor‐like receptor (CLR) are two of the 15 human family B (or Secretin‐like) GPCRs. CTR and CLR are of considerable biological interest as their pharmacology is moulded by interactions with receptor activity‐modifying proteins.
Barwell, James +5 more
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Solubilization of functional calcitonin receptors [PDF]
Biochemical Journal, 1988 Calcitonin (CT) binding activity has been extracted from a membrane fraction of human placenta using the zwitterionic detergent, 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulphonic acid (Chaps). Approximately two-thirds of the available binding sites were extracted using 5 mM-Chaps. The binding characteristics of 125I-labelled salmon CT(125I-sCT)
Nicholson, G.C. +5 more
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