Results 41 to 50 of about 26,165 (305)

Intermedin Is a Calcitonin/Calcitonin Gene-related Peptide Family Peptide Acting through the Calcitonin Receptor-like Receptor/Receptor Activity-modifying Protein Receptor Complexes [PDF]

Journal of Biological Chemistry, 2004
Calcitonin, calcitonin gene-related peptide (CGRP), adrenomedullin (ADM), and amylin belong to a unique group of peptide hormones important for homeostasis in diverse tissues. Calcitonin is essential for calcium balance, whereas CGRP and ADM are important for neurotransmission and cardiovascular and respiratory regulation.
Jaesook, Roh, Chia Lin, Chang, Alka, Bhalla, Cynthia, Klein, Sheau Yu Teddy, Hsu   +4 more
openaire   +2 more sources

Calcitonin gene-related peptide is a stimulator of renin secretion

, 1988
Calcitonin gene-related peptide (CGRP) was found to stimulate renin secretion in vivo in normal human volunteers. Moreover, CGRP stimulated the release of renin in vitro from isolated rat renal juxtaglomerular cells (half-maximal effective concentration [
Fischer, J. A., R Muff, Gnädinger, M. P., Uehlinger, D. E., Weidmann, P., A Kurtz, M P Gnädinger, W Born, Muff, R., J M Lundberg, T Hökfelt, P Weidmann, Kurtz, Armin, Lundberg, J. M., D E Uehlinger, Born, W., Millberg, B. I., Hökfelt, T., J A Fischer, B I Millberg   +19 more
core   +1 more source

Activation of renal pelvic chemoreceptors in rats: role of calcitonin gene-related peptide receptors [PDF]

, 2015
Substance P and calcitonin gene-related peptide (CGRP) increase afferent renal nerve activity (ARNA). A substance P receptor antagonist but not a CGRP receptor antagonist, h-CGRP (8-37), blocks the ARNA response to renal mechanoreceptor (MRI stimulation.
Gontijo, JAR, Kopp, UC
core   +2 more sources

CGRP and the Calcitonin Receptor are Co-Expressed in Mouse, Rat and Human Trigeminal Ganglia Neurons

Frontiers in Physiology, 2022
The neuropeptide calcitonin gene-related peptide (CGRP) is expressed in the trigeminal ganglia, a key site in craniofacial pain and migraine. CGRP potently activates two receptors: the CGRP receptor and the AMY1 receptor. These receptors are heterodimers
Tayla A. Rees, Tayla A. Rees, Andrew F. Russo, Simon J. O’Carroll, Debbie L. Hay, Debbie L. Hay, Christopher S. Walker, Christopher S. Walker   +7 more
doaj   +1 more source

Specificity of Porcine Calcitonin Receptor and Calcitonin Receptor-like Receptor in the Presence of Receptor-Activity-Modifying Proteins

Hypertension Research, 2003
Adrenomedullin (AM), calcitonin gene-related peptide (CGRP), amylin (AMY) and calcitonin (CT) are members of the CGRP/CT superfamily of peptides. Among them, AM and CGRP are reported to share a core receptor, the calcitonin receptor-like receptor (CRLR), and the specificity of the CRLR is determined by the expression levels of receptor-activity ...
KIKUMOTO, Katsuro, KATAFUCHI, Takeshi, MINAMINO, Naoto   +2 more
openaire   +3 more sources

CALCITONIN: ANTAGONISM AT INTESTINAL MUSCARINIC RECEPTORS [PDF]

British Journal of Pharmacology, 1976
The action of calcitonin was studied on the motility of isolated innervated segments of rabbit and guinea‐pig intestines as well as longitudinal muscle with adherent myenteric plexus dissected from the guinea‐pig ileum. Calcitonin (0.25 μm) antagonized contractile responses to acetylcholine and the cholinergic response to electrical field stimulation ...
C F, Dreyfus, M D, Gershon, A, Haymovits, E, Nunez   +3 more
openaire   +2 more sources

Overview of Calcitonin Gene-Related Peptide and Its Receptor

The Scientific World Journal, 2001
Calcitonin Gene-Related Peptide (CGRP), a 37 amino acid peptide identified as the alternately spliced gene product of calcitonin gene, is a sensory neuropeptide with potent cardiovascular effects. CGRP is distributed throughout the central and peripheral
Nambi Aiyar
doaj   +1 more source

The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach [PDF]

, 2013
The calcitonin gene-related peptide (CGRP) receptor is a complex of a calcitonin receptor-like receptor (CLR), which is a family B G-protein-coupled receptor (GPCR) and receptor activity modifying protein 1.
Poyner, David, Reynolds, Christopher A., Hay, Debbie L., Poyner, David R, Karakullukcu, Z. Gamze, Woolley, Michael J, Barwell, James, Karakullukcu, Z Gamze, Poyner, David R., Smith, Kevin J., Taddese, Bruck, Reynolds, Christopher A, Conner, Alex C., Hay, Debbie L, Watkins, Harriet A., Watkins, Harriet A, Conner, Alex C, Smith, Kevin J, Woolley, Michael J.   +18 more
core   +1 more source

Effects of Salmon Calcitonin on the Concentrations of Monoamines in Periaqueductal Gray in Formalin Test

Balkan Medical Journal, 2019
Background: The receptors of salmon calcitonin, located on certain areas of the brain such as the periaqueductal gray matter, are responsible for pain modulation.
Kaveh Rahimi, Javad Sajedianfard, Ali Akbar Owji   +2 more
doaj   +1 more source

Lipidated Calcitonin Gene-Related Peptide (CGRP) Peptide Antagonists Retain CGRP Receptor Activity and Attenuate CGRP Action In Vivo

Frontiers in Pharmacology, 2022
Signaling through calcitonin gene-related peptide (CGRP) receptors is associated with pain, migraine, and energy expenditure. Small molecule and monoclonal antibody CGRP receptor antagonists that block endogenous CGRP action are in clinical use as anti ...
Aqfan Jamaluddin, Chia-Lin Chuang, Elyse T. Williams, Andrew Siow, Sung Hyun Yang, Paul W. R. Harris, Jakeb S. S. M. Petersen, Rebekah L. Bower, Shanan Chand, Margaret A. Brimble, Christopher S. Walker, Debbie L. Hay, Debbie L. Hay, Kerry M. Loomes   +13 more
doaj   +1 more source