Results 31 to 40 of about 26,165 (305)

A Native PAGE Assay for the Biochemical Characterization of G Protein Coupling to GPCRs

Bio-Protocol, 2021
G protein-coupled receptors (GPCRs) are a large family of membrane-embedded receptors that have diverse roles in physiology and are major drug targets. GPCRs transduce an agonist binding signal across the membrane to activate intracellular heterotrimeric
Amanda Roehrkasse, Jordan Karim, Augen Pioszak   +2 more
doaj   +1 more source

Calcitonin receptors in GtoPdb v.2021.2

, 2021
This receptor family comprises a group of receptors for the calcitonin/CGRP family of peptides. The calcitonin (CT), amylin (AMY), calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) receptors (nomenclature as agreed by the NC-IUPHAR ...
Walker, Christopher S., Hay, Debbie, Poyner, David R.   +2 more
core   +1 more source

Mechanisms of the analgesic effect of calcitonin on chronic pain by alteration of receptor or channel expression

Molecular Pain, 2017
The polypeptide hormone calcitonin is well known clinically for its ability to relieve osteoporotic back pain and neuropathic pain such as spinal canal stenosis, diabetic neuropathy, chemotherapy-induced neuropathy, and complex regional pain syndrome ...
Akitoshi Ito, Megumu Yoshimura
doaj   +1 more source

Inefficient constitutive inhibition of P2X3 receptors by brain natriuretic peptide system contributes to sensitization of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine

Molecular Pain, 2016
Background On trigeminal ganglion neurons, pain-sensing P2X3 receptors are constitutively inhibited by brain natriuretic peptide via its natriuretic peptide receptor-A. This inhibition is associated with increased P2X3 serine phosphorylation and receptor
Anna Marchenkova PhD, Sandra Vilotti PhD, Niels Ntamati MS, Arn MJM van den Maagdenberg PhD, Andrea Nistri MD   +4 more
doaj   +1 more source

Perampanel inhibits calcitonin gene-related peptide release from rat brainstem in vitro

The Journal of Headache and Pain, 2018
Background Perampanel is a novel antiepileptic drug acting via non-competitive antagonism on glutamatergic AMPA receptors, and the subsequent inhibition of ion calcium influx.
Giuseppe Tringali, Diego Currò, Pierluigi Navarra   +2 more
doaj   +1 more source

Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies [PDF]

, 2012
Modelling class B G-protein-coupled receptors (GPCRs) using class A GPCR structural templates is difficult due to lack of homology. The plant GPCR, GCR1, has homology to both class A and class B GPCRs. We have used this to generate a class A–
Poyner, David, Reynolds, Christopher A., Hay, Debbie L., Poyner, David R, Barwell, James, Upton, Graham J.G., Poyner, David R., Reeves, Philip J., Upton, Graham J. G., Taddese, Bruck, Reeves, Philip J, Reynolds, Christopher A, Conner, Alex C., Hay, Debbie L, Conner, Alex C, Vohra, Shabana, Upton, Graham JG   +16 more
core   +1 more source

Gα_s-Coupled CGRP Receptor Signaling Axis from the Trigeminal Ganglion Neuron to Odontoblast Negatively Regulates Dentin Mineralization

Biomolecules, 2022
An inflammatory response following dental pulp injury and/or infection often leads to neurogenic inflammation via the axon reflex. However, the detailed mechanism underlying the occurrence of the axon reflex in the dental pulp remains unclear.
Natsuki Saito, Maki Kimura, Takehito Ouchi, Tatsuya Ichinohe, Yoshiyuki Shibukawa   +4 more
doaj   +1 more source

Calcitonin gene products and the kidney

, 1989
Calcitonin gene-related peptide (CGRP) is localized in capsaicin-sensitive nerve fibres in the kidney and urogenital tract whereas calcitonin reaches the kidney through the general circulation.
Fischer, J. A., Kurtz, Armin, Muff, R.
core   +1 more source

Calcitonin and calcitonin receptors: bone and beyond

International Journal of Experimental Pathology, 2000
Calcitonin (CT), a 32 amino acid peptide hormone produced primarily by the thyroid, and its receptor (CTR) are well known for their ability to regulate osteoclast mediated bone resorption and enhance Ca2+ excretion by the kidney. However, recent studies now suggest that CT and CTRs may play an important role in a variety of processes as wide ranging as
openaire   +3 more sources

Association between calcitonin receptor gene polymorphisms and calcium stone urolithiasis: A meta-analysis [PDF]

International Brazilian Journal of Urology, 2019
Purpose It has been reported that calcitonin receptor (CALCR) gene polymorphisms might be associated with calcium stone urolithiasis. Owing to mixed and inconclusive results, we conducted a meta-analysis to summarize and clarify this association ...
Jinchun Xing, Jiaxuan Qin, Zonglong Cai, Bo Duan, Peide Bai   +4 more
doaj   +1 more source