Results 61 to 70 of about 26,165 (305)

Biodegradable Zn‐Based Implants: Progress, Challenges, and Pathways toward Clinical Translation

Advanced Science, EarlyView.
Exploring biodegradable Zn‐based implants offers a promising pathway to next‐generation biomedical devices with balanced degradation and biocompatibility. A comprehensive overview of biodegradable Zn‐based implants, covering their biological significance, material design principles, and advanced engineering strategies is provided.
Panfeng Zhao, Zhengquan Wang, Hui Yang, Xiyuan Zhang, Hanyuan Liu, Xiaotong Lu, Xiaocheng Li, Yanyan Liu, Xi Zhao, Wenhao Zhou, Yufeng Zheng   +10 more
wiley   +1 more source

The Calcitonin and Glucocorticoids Combination: Mechanistic Insights into Their Class-Effect Synergy in Experimental Arthritis

, 2013
PMCID: PMC3564948This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Trinidad Montero-Melendez, Mauro Perretti, Al-Kashi, A, Montero-Melendez Trinidad, Niloufar Moradi-Bidhendi (279360), Trinidad Montero-Melendez (241688), Adam Al-Kashi, Gilligan James P., Al-Kashi Adam, Mehta, N, Moradi-Bidhendi Niloufar, Moradi-Bidhendi, N, Perretti, M, Nozer Mehta, Mehta Nozer, Nozer Mehta (279362), Mauro Perretti (241694), Gilligan, JP, Montero-Melendez, T, James P. Gilligan (279361), Niloufar Moradi-Bidhendi, James P Gilligan, Adam Al-Kashi (279359), Perretti Mauro   +23 more
core   +1 more source

Mechanistic investigation of Liujing Toutong tablet in the treatment of cerebral ischemia–reperfusion injury in rats by the integration of serum pharmacochemistry and metabolomics

Animal Models and Experimental Medicine, EarlyView.
The research strategy for pharmacodynamics, serum pharmacochemistry, metabolomics, and network pharmacology analysis method in intervention effects of LTT are illustrated. Abstract Background Liujing Toutong tablet (LTT) is a traditional Chinese patent medicine.
Zihan Yu, Ke Pei, Xiulin Wang, Wenling Li, Hongchang Li, Wangyang Xie, Xianglong Meng, Tingting Zhao, Yan Ning, Haixin Liu, Wenbin He   +10 more
wiley   +1 more source

Calcitonin gene-related peptide (CGRP) receptors are important to maintain cerebrovascular reactivity in chronic hypertension. [PDF]

PLoS ONE, 2015
Cerebral blood flow autoregulation (CA) shifts to higher blood pressures in chronic hypertensive patients, which increases their risk for brain damage. Although cerebral vascular smooth muscle cells express the potent vasodilatatory peptides calcitonin ...
Zhenghui Wang, Belén Cantó Martorell, Thomas Wälchli, Olga Vogel, Jan Fischer, Walter Born, Johannes Vogel   +6 more
doaj   +1 more source

Identification of key components in the irreversibility of salmon calcitonin binding to calcitonin receptors [PDF]

Journal of Endocrinology, 2000
This study investigates the poor reversibility of salmon calcitonin (sCT) binding to rat and human calcitonin receptors. Efficacy of CT and analogue peptides in (125)I-sCT binding competition and cAMP assays was compared with the dissociation kinetics of (125)I-labelled peptides.
J M, Hilton, M, Dowton, S, Houssami, P M, Sexton   +3 more
openaire   +2 more sources

Distinct Patterns of Internalization of Different Calcitonin GeneRelated Peptide Receptors [PDF]

, 2020
Calcitonin gene-related peptide (CGRP) is a neuropeptide that is involved in the transmission of pain. Drugs targeting CGRP or a CGRP receptor are efficacious in the treatment of migraine.
Gingell, Joseph J., Hay, Debbie L., Harris, Paul W.R., Rees, Tayla A.; id_orcid, Siow, Andrew, Walker, Christopher S., Rees, Tayla A, Brimble, Margaret A, Scotter, John, Hendrikse, Erica R., Brimble, Margaret A., Rennison, David, Harris, Paul W R, Hay, Debbie L, Gingell, Joseph J, Hendrikse, Erica R, Walker, Christopher S   +16 more
core   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Isolation and functional characterization of calcitonin-like diuretic hormone receptors in Rhodnius prolixus. [PDF]

PLoS ONE, 2013
Several families of diuretic hormones exist in insects, one of which is the calcitonin-like diuretic hormone (CT/DH) family. CT/DH mediates its effects by binding to family B G-protein coupled receptors (GPCRs).
Meet Zandawala, Shizhong Li, Frank Hauser, Cornelis J P Grimmelikhuijzen, Ian Orchard   +4 more
doaj   +1 more source

Regulation by Calcitonin and Glucocorticoids of Calcitonin Receptor Gene Expression in Mouse Osteoclasts [PDF]

Endocrinology, 1997
We previously studied regulation of the calcitonin (CT) receptor (CTR) by glucocorticoid (GC) and CT in cultures of mature mouse osteoclast-like cells (OCLs). The present studies were designed to examine the interaction of CT and GC in regulation of the CTR in osteoclasts and the molecular mechanisms involved.
Wada, S., Udagawa, N., Akatsu, T., Nagata, N., Martin, T., Findlay, D.   +5 more
openaire   +3 more sources

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source